Clinical trials: Remote Ischaemic Preconditioning
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Coronary Artery Ischemia
Remote Myocardial Ischemic Preconditioning in Humans
Ischemic preconditioning (IP) has been shown in animal studies to increase the myocardial tolerance to subsequent ischemia. Our primary hypothesis is that remote IP reduces myocardial ischemic injury during PCI.
- Trial name
- RemoteMIPH (NCT00588042)
- Testing
- Blood pressure cuff
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Mayo Clinic
Myocardial Infarction
Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)
This study involves research using human subjects (cardiac surgical patients) to evaluate the effect of remote ischemic preconditioning (RIPC) on cardioprotective outcomes.
- Trial name
- NCT02932722
- Testing
- Control, Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Seoul National University Hospital
Abdominal Aortic Aneurysm
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair
To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
- Trial name
- NCT01344239
- Testing
- Limb remote ischemic preconditioning(LRIP)
- Volunteers
- 62 people
- Sponsor
- Cai Li
Organ Transplantation
Remote Ischemic Preconditioning in Neurological Death Organ Donors
The purpose of this study is to determine whether application of lower limb remote ischemic preconditioning (RIPC) after determination of brain death improves donor stability, organ quality, organ yield, and early post transplant…
- Trial name
- RIPNOD (NCT01515072)
- Testing
- RIPC (Remote Ischemic Preconditioning)
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Rutgers, The State University of New Jersey
Coronary Artery Disease
The Saint Francis Remote Ischemic Preconditioning Trial (SaFR)
This study tests the hypothesis that repeated inflation of a blood pressure cuff on the arm will improve results of coronary stent implantation by: reducing chest pain and electrocardiogram changes during balloon inflation to…
- Trial name
- SaFR (NCT01078272)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Francis Hospital, New York
Acute Coronary Syndrome, Renal Insufficiency
Remote Ischemic Preconditioning in ACS Patients
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and deflations that are performed prior to a procedure and have been shown in various other areas (coronary bypass surgery, vascular surgery…
- Conditions
- Acute Coronary Syndrome, Renal Insufficiency, Ischemia, Myocardial
- Trial name
- NCT03329612
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Sponsor
- Henry Ford Health System
Obstructive Sleep Apnea, Vascular Aneurysm
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure.
- Conditions
- Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
- Trial name
- NCT04630535
- Testing
- aorto-bifemoral bypass surgery
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning in patient undergoing coronary angioplasty.
- Trial name
- SCRIP (NCT02649309)
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 370 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Left Ventricular Dysfunction
Pilot Study of Remote Ischemic Preconditioning in Heart Failure
The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.
- Trial name
- NCT01128790
- Testing
- Remote ischemic preconditioning
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Acute Lung Injury
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage
Background: In patients undergoing lung lobectomy, lung collapse and re-expansion after resection is associated to severe oxidative lung injury.
- Trial name
- NCT02734654
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 53 people
- Sponsor
- Instituto de Salud Carlos III
Cyanosis
Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery
This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.
- Trial name
- NCT01311310
- Testing
- RIPC (remote ischemic preconditioning)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery
The project has been designed to determine whether a brief period of leg ischemia will reduce the I/R injury sustained by the liver during liver surgery and liver transplantation.
- Trial name
- NCT00796588
- Testing
- remote preconditioning
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Royal Free Hampstead NHS Trust
Ischemic Preconditioning
Conditioning Based Intervention Strategies
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resistance training (TRT) and low…
- Trial name
- ConBIS (NCT03380663)
- Testing
- Remote Ischemic Conditioning (RIC)
- Where
- Denmark
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Laparoscopic Colorectal Surgery
Limb Remote Ischemic Preconditioning for Heart and Intestinal Protection During Laparoscopic Colorectal Surgery
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators hypothesized that limb remote ischemic preconditioning (RIPC) would reduce heart and gastrointestinal function injury in…
- Trial name
- NCT01832337
- Testing
- Limb remote ischemic preconditioning (LRIP)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fei Li
Renal Cell Carcinoma
Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney.
- Trial name
- NCT01836406
- Testing
- Ketorolac tromethamine and remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University