Clinical trials: Remote Ischemic Preconditioning
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Myocardial Reperfusion Injury
Investigation Into the Role of GTN & RIPC in Cardiac Surgery
The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic preconditioning (RIPC).
- Trial name
- ERIC-GTN (NCT01864252)
- Testing
- Remote ischaemic preconditioning, IV Normal saline, IV Glyceryl trinitrate 2-5ml/h
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University College, London
Ischemic Heart Disease
Effect of Remote Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
In recent several clinical trials, remote preconditioning showed very powerful myocardial protection. However, the myocardial protective effect by remote preconditioning was not evaluated on the patients undergoing off pump…
- Trial name
- NCT00889811
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Brain Ischemia, Postoperative Confusion
Impact of Remote Ischemic Preconditioning Preceding Coronary Artery Bypass Grafting on Inducing nEuroprotection
Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with severe CAD are often treated with coronary artery bypass grafting (CABG).
- Trial name
- RIPCAGE (NCT02177981)
- Testing
- Remote ischemic preconditioning, Control
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Zagreb
Colon Cancer, Fragility
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer.
- Conditions
- Colon Cancer, Fragility, Prehabilitation, Surgery
- Trial name
- Prehab (NCT03853473)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical College of Wisconsin
Cardiovascular Disease
Exercise Test and Cardiac Injury
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply…
- Trial name
- NCT01660828
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Obstructive Sleep Apnea, Vascular Aneurysm
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure.
- Conditions
- Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
- Trial name
- NCT04630535
- Testing
- aorto-bifemoral bypass surgery
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Burn Injury, Acute Wound
Cutaneous Microcirculation After Remote Ischemic Preconditioning
In plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds and chronic wounds aim at reducing infection and improving microcirculation.
- Conditions
- Burn Injury, Acute Wound, Chronic Wound
- Trial name
- NCT02417805
- Testing
- Intervention: Remote Ischemic Preconditioning
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Schleswig-Holstein
Myocardial Injury
Effects of Remote Ischemic PreConditioning in Off-pump Versus On-pump Coronary Artery Bypass Grafting(RIPCON)
Purpose Remote ischemic preconditioning (RIPC) with transient upper limb ischemia reduces myocardial injury in patients undergoing On-pump coronary artery bypass (CABG) surgery with cross-clamp fibrillation or blood cardioplegia…
- Trial name
- RIPCON (NCT01608984)
- Testing
- Remote ischemic preconditioning (RIPC), Coronary artery bypass grafting (CABG) without remote ischemic preconditioning protocol, Off-pump Coronary artery bypass surgery without remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Nephropathy
Interest of Remote Ischemic Preconditioning for Prevention of Contrast Medium-induced Nephropathy in High Risk Patients
Diagnostic imaging for vascular investigations and endovascular procedures frequently require the use of contrast medium. Besides contrast medium-induced hypersensitivity, an acute kidney injury can appear: the contrast-induced…
- Trial name
- IPC-Angio (NCT02470247)
- Testing
- Remote Ischemic Preconditioning (RIPC)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Heart Diseases, Atrial Fibrillation
Clinical Value of Remote Ischemic Preconditioning
Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary.
- Trial name
- NCT01740102
- Testing
- RIPC
- Where
- Norway
- Volunteers
- 92 people
- Sponsor
- Norwegian University of Science and Technology
Renal Disease
Remote Ischemic Preconditioning Living Donor Renal Transplant Protocol
In this study, patients undergoing live donor kidney transplantation will be allocated to the control group or remote ischemic preconditioning group (RIPC).
- Trial name
- NCT03084666
- Testing
- Zimmer ATS tourniquet system
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Carotid Artery Stenosis
Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Remote limb ischemic preconditioning (RIPC) has neuro-protective and anti-inflammatory effects on ischemia- reperfusion injury. As the extent of its effect is unknown, the investigators will use clinical outcome, serum…
- Trial name
- NCT01654666
- Testing
- Remote ischemic preconditioning, Carotid Artery Stenting
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Ji Xunming
Acute Coronary Syndrome, Renal Insufficiency
Remote Ischemic Preconditioning in ACS Patients
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and deflations that are performed prior to a procedure and have been shown in various other areas (coronary bypass surgery, vascular surgery…
- Conditions
- Acute Coronary Syndrome, Renal Insufficiency, Ischemia, Myocardial
- Trial name
- NCT03329612
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Sponsor
- Henry Ford Health System
Peripheral Arterial Disease
Cardiac Remote Ischemic Preconditioning Before Elective Major Vascular Surgery
Vascular surgery is considered a high-risk operation with an anticipated risk of major cardiovascular complications in excess of 5%.
- Trial name
- CRIPES (NCT01403337)
- Testing
- Ischemic preconditioning, Control
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Center for Veterans Research and Education
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Coronary Heart Disease
Effect of Remote Ischaemic Preconditioning on Clinical Outcomes in CABG Surgery
Coronary heart disease (CHD) is the leading cause of death in the UK, accounting for 124,000 deaths (2006) and costing the UK economy over £7.9 billion a year.
- Trial name
- ERICCA (NCT01247545)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- 28 sites in United Kingdom
- Volunteers
- 1,612 people
- Sponsor
- University College, London
Peripheral Arterial Disease
A Study on the Phenomenon of Remote Ischaemic Preconditioning in Patients With Peripheral Artery Disease
This study aims to evaluate whether remote ischemic preconditioning (RIPC) daily for 28 days reduces the symptoms of intermittent claudication in patients with peripheral artery disease (PAD).
- Trial name
- NCT05084066
- Testing
- Repeated remote ischemic preconditioning
- Where
- Estonia
- Volunteers
- 42 people
- Sponsor
- Tartu University Hospital
Kidney Disease, Liver Disease
Remote Ischemic Preconditioning In Abdominal Organ Transplantation
Does remote ischemic preconditioning (RIPC) induced by a brief period of occlusion of blood flow to the lower extremity prior to organ recovery in deceased donors, improve short and long term outcomes after transplantation of…
- Conditions
- Kidney Disease, Liver Disease, Pancreas Disease
- Trial name
- RIPCOT (NCT00975702)
- Testing
- RIPC by Inflation of Pneumatic Tourniquet
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Medicine and Dentistry of New Jersey