Clinical trials: Renal Dysfunction
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Chronic Kidney Disease
Home-Based Exercise to Treat Decreased Physical Function in Patients With Varying Levels of Kidney Function
The investigators will conduct a pilot study to determine whether home-based exercise is an effective intervention to improve decreased physical function in kidney transplant candidates.
- Trial name
- NCT04745169
- Testing
- 8 week home-based exercise program
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Renal Failure
A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function
A study to evaluate the drug effect, safety, and tolerability of BMS-986259 in participants with different levels of kidney function
- Trial name
- NCT04237831
- Testing
- BMS-986259
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Pharmacokinetics of Isavuconazole, Healthy Volunteers
Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.
This is a 2-part, open-label study, designed to evaluate the effect of renal disease on the pharmacokinetics of BAL4815 (active isavuconazole moiety) relative to the pharmacokinetics in healthy subjects with normal renal function.
- Conditions
- Pharmacokinetics of Isavuconazole, Healthy Volunteers, Renal Impaired
- Trial name
- NCT01555866
- Testing
- isavuconazole
- Where
- 3 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Chronic Kidney Disease Patients
Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).
- Trial name
- GlikoOxEND (NCT07437729)
- Where
- Croatia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2
Vitamin D Supplement in patients with CKD stage 1 and 2 may change osteoprotegin expression so as to produce beneficial effects of cardiovascular、bone metabolism and CKD progression.
- Trial name
- NCT01561222
- Testing
- Calcitriol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Taixing People's Hospital
Renal Insufficiency, Chronic
Survey of Patient and Physician Awareness and Values to the Diagnosis and Treatment of Reduced Kidney Function (Chronic Kidney Disease) in Patients With High Blood Sugar Level (Type 2 Diabetes) (AWARE-CKD in T2D)
In this survey study, researchers want to find out more about how physicians are treating patients diagnosed with reduced kidney function (chronic kidney disease, CKD) and high blood sugar level (type 2 diabetes); what physicians…
- Trial name
- AWARE-CKD (NCT04498156)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bayer
Severe Sepsis, Shock, Septic
L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury
The primary objective of this study is to compare 28 day mortality rates between septic shock patients with acute renal insufficiency treated via L-Carnitine (as an adjunct therapy) versus a similar group of patients not…
- Conditions
- Severe Sepsis, Shock, Septic, Acute Kidney Injury
- Trial name
- CarniSave (NCT02664753)
- Testing
- 56 days of weight-adjusted L-Carnitine treatment
- Where
- 11 sites in France
- Volunteers
- 254 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Myeloma
Study of Induction Treatment With Velcade and Dexamethasone for Previously Untreated Patients With Multiple Myeloma and Renal Failure
Primary outcome measure: Analyze the efficacy (in order to evaluate the response) of Bortezomib/Dexamethasone treatment Secondary outcome measures: Study the speed of response and the response rate (M component in serum and urine…
- Trial name
- RENVEL (NCT01084837)
- Testing
- velcade
- Where
- 11 sites in Spain
- Volunteers
- 60 people
- Sponsor
- PETHEMA Foundation
Nephrogenic Systemic Fibrosis, Renal Failure
Nephrogenic Systemic Fibrosis With Gadollinum
Recently there is increasing reports of NEPHROGENIIC SYSTEMIC FIBROSIS(NSF) in patients with severe renal failure mainly in patients under dialysis in whom gadollinum is being used.
- Trial name
- NSF (NCT01359345)
- Testing
- gadollinum
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Imam Khomeini Hospital
Renal Insufficiency
Renal Safety Evaluation After Dotarem®-Enhanced MRI
Although there is a well documented risk of acute renal failure with the iodinated contrast agents, the implication of intravenous gadolinium-based contrast agents in nephrotoxicity remains controversial.
- Trial name
- RESCUE (NCT00650845)
- Testing
- Dotarem®-enhanced MRI, non-enhanced MRI
- Where
- 15 sites in Belgium, France and 2 more
- Volunteers
- 135 people
- Sponsor
- Guerbet
Type 2 Hepatorenal Syndrome, Refractory Ascites
The Use of Drugs to Improve Kidney Function in Patients With Liver and Kidney Dysfunction
We will address the hypothesis that refractory ascites and Type 2 hepatorenal syndrome are mediated in part by diminished circulatory volume and that treatment with midodrine, octreotide and albumin can improve renal and patient…
- Trial name
- NCT00240045
- Testing
- Midodrine, albumin, octreotide LAR, midodrine, octreotide, albumin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Alberta
Hemodialysis, End Stage Renal Disease
Comparative Effects of Milk Thistle Extract With Vitamin-E in Hemodialysis Patients
For end-stage renal disease (ESRD) patients, cardiovascular disease remains the single most common cause of excess morbidity and mortality.
- Trial name
- NCT01001845
- Testing
- Milk Thistle extract, vit E, vit E + Milk Thistle extract
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shiraz University of Medical Sciences
Acute Kidney Injury, Cardiac Surgery
Kidney Oxygen Saturation and Neutrophil Gelatinase-associated Lipocalin (NGAL) for Detecting Acute Kidney Injury (AKI) After Cardiac Surgery
Acute kidney injury (AKI) is an important complication following cardiac surgery with cardiopulmonary bypass (CPB). Early identification of patients at risk of AKI may facilitate timely clinical management.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07837037
- Testing
- Renal Near-Infrared Spectroscopy Monitoring, Neutrophil Gelatinase-Associated Lipocalin (NGAL) Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Haseki Training and Research Hospital
Diabetes
Pharmacokinetics and Safety Profile of a Single Dose GZR4 in Subjects with Renal Impairment
This study will be conducted to investigated the effect of decreased kidney function on PK and safety of GZR4 and to guide dosing recommendations in people with kidney impairment.
- Trial name
- NCT06547502
- Testing
- GZR4
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Overweight and Obesity
A Trial to Assess the Effect of Kidney Impairment on How AMG 133 is Absorbed, Broken Down, and Eliminated by the Body
The primary objective of this trial is to evaluate the pharmacokinetics of a single subcutaneous (SC) dose of AMG 133 in participants with various degrees of renal impairment compared to participants with normal renal function.
- Trial name
- NCT07429045
- Testing
- AMG 133
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Amgen
Anaemia
Evaluation of Dose Response Relationship, Safety and Efficacy of GSK1278863 in Hemodialysis-dependent Subjects With Chronic Kidney Disease Associated Anemia
This study is intended to evaluate the dose-response relationship of GSK1278863 over the first 4 weeks of treatment and evaluate the safety and efficacy of GSK1278863 over 24 weeks to maintain hemoglobin (Hgb) level in…
- Trial name
- NCT01977482
- Testing
- GSK1278863, rhEPO
- Where
- 107 sites in United States, Australia and 14 more
- Volunteers
- 216 people
- Sponsor
- GlaxoSmithKline
Chronic Kidney Disease
Efficacy and Safety of HRS-1780 Tablets and Henagliflozin Proline Tablets in Patients With Chronic Kidney Disease
The objective of this study was to evaluate the efficacy of HRS-1780 tablets or Henagliflozin Proline tablets in patients with chronic kidney disease by evaluating UACR change from baseline to Week 13
- Trial name
- NCT06221059
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
End-stage Renal Disease
Efficacy Trial of Fluid Distribution Timetable
Nonadherence to fluid restriction is a significant issue among hemodialysis patients globally, with numerous adverse health outcomes.
- Trial name
- NCT05797766
- Testing
- Fluid Distribution Timetable
- Where
- Philippines
- Volunteers
- 40 people
- Sponsor
- University of Santo Tomas
End-stage Renal Disease
Solute Removal With High Volume Hemodiafiltration Versus Long High Flux Hemodialysis
This is a prospective cross-over study including 10 stable hemodialysis patients with chronic kidney disease stage 5. The cross-over study lasts 2 weeks with the study dialysis sessions at midweek.
- Trial name
- NCT01445366
- Testing
- High volume post dilution hemodiafiltration, high flux hemodialysis
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Ghent
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