Clinical trials: Renal Dysfunction
Kidney Injury, Kidney Disease, Chronic
Early Diagnosis of Kidney Damage Associated With Tobacco Use
Tobacco consumption is associated with the appearance of several pathologies, the best known are Chronic Obstructive Pulmonary Disease, several types of cancer and cardiovascular diseases.
- Conditions
- Kidney Injury, Kidney Disease, Chronic, Tobacco Toxicity
- Trial name
- NCT03850756
- Testing
- Early kidney damage biomarkers, Predisposition to kidney injury biomarkers, Tobacco consumption
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Chronic Renal Disease, Diabetic Foot
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Context and hypothesis: The prevalence of diabetes mellitus keeps going to increase, due to the ageing of the population and the high prevalence of overweight and obesity.
- Trial name
- NEPHROPOD (NCT04100551)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Participants With Moderate and Severe Renal Impairment and Healthy Participants
A Study to Investigate the Pharmacokinetics and Safety of PKN605 in Participants With Moderate and Severe Renal Impairment Compared to Matched Control Subjects With Normal Renal Function
The purpose of this trial is to assess any potential exposure increases of PKN605 in participants with reduced renal function to support decisions on participant eligibility and dosing in subsequent clinical trials of PKN605.
- Trial name
- NCT07797322
- Testing
- PKN605
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Chronic Renal Failure
Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies
The vascular endothelium is an organ in its own right, playing, among other things, a primordial role in the control of vascular tone.
- Trial name
- NCT06347029
- Testing
- Urine sampling, Blood sampling, Flow mediated dilatation test
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Renal Impairment
A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function
The purpose of this study is to understand how the loss of kidney function affects study medicine (PF-07923568) in the body. People with some level of loss of kidney function may process PF-07923568 differently from healthy…
- Trial name
- NCT06037031
- Testing
- Drug: PF-07923568
- Where
- 6 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hemodialysis, End Stage Kidney Disease (ESKD)
Dialysis Less Frequently in the Elderly
Many people who have kidney failure require hemodialysis treatments to stay alive. Hemodialysis is a procedure that cleans the blood of the toxins and fluids that build up when kidneys don't work.
- Trial name
- DLITE (NCT07738731)
- Testing
- Twice weekly hemodialysis, Thrice weekly hemodialysis treatment
- Where
- 11 sites in Canada
- Volunteers
- 210 people
- Sponsor
- Queen's University
Kidney Injury, Kidney Failure
Personalization of Immunosuppressive Treatment for Organ Transplant Recipients
Long-term graft failure rates continue to be unacceptably high despite the development of immunosuppressive drugs, underscoring the unmet need for robust prognostic biomarkers of allograft injury and failure.
- Conditions
- Kidney Injury, Kidney Failure, Kidney Failure, Chronic, Kidney Failure, Acute
- Trial name
- STAART (NCT05747053)
- Testing
- AlloSure, PAXGene
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- George Washington University
Restless Legs Syndrome, End Stage Renal Disease
Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD
Restless legs syndrome (RLS) is a neurologic disorder characterized by 1) an urge to move the legs, 2) uncomfortable sensations in the legs, 3) symptoms that are often worse the evening or when at rest , and 4) may be temporarily…
- Trial name
- NCT03708237
- Testing
- Ropinirole, Gabapentin
- Where
- 4 sites in Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Chronic Kidney Disease (CKD), Elderly
Citalopram and the Risk of Serious Adverse Events
This population-based cohort study aims to evaluate the safety of initiating a new outpatient prescription of citalopram at 20 mg/day (higher dose) compared to 10 mg/day (lower dose) in adults aged 65 years and older with reduced…
- Conditions
- Chronic Kidney Disease (CKD), Elderly, Outpatient
- Trial name
- NCT07399795
- Testing
- Citalopram 10 MG, Citalopram 20 MG
- Where
- Canada
- Volunteers
- 7,110 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury
SIRAKI 02 Posthoc Analysis.
Our randomized controlled trial with 343 patients requiring non emergent cardiac surgery with a prolonged expected cardiopulmonary bypass (CPB) time (>90 minutes) demonstrated that the use of an extracorporeal blood purification…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury, Chronic Kidney Disease(CKD), Kidney Failure, Acute
- Trial name
- OXI-SAFE-CEC (NCT06781294)
- Testing
- Extracorporeal Cytokine hemadsorption therapy
- Where
- Spain
- Volunteers
- 343 people
- Sponsor
- Hospital Universitari de Bellvitge
Other Complication of Vascular Dialysis Catheter
Effect of the TEGO Connector in Preventing Tunneled Cuffed Hemodialysis Catheters From Dysfunction and/or Bacteremia
The aim of the trial was to assess whether use of the TEGO connector was able to reduce the incidence of a composite endpoint of TCC-related dysfunction (TCC-D)or TCC-related bacteremia (TCC-B) in chronic hemodialysis (HD)…
- Trial name
- NCT01689753
- Testing
- TEGO connector®, Trisodium citrate
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Erasme University Hospital
Disorder Related to Lung Transplantation
Copenhagen Acute Renal Complications After Transplantations Study Group
Lung transplanted patients experience marked decrease in renal function post transplant mainly due to cyclosporine induced renal changes.
- Trial name
- CARCATS (NCT02744872)
- Testing
- Felodipine
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Decompensated Heart Failure (ADHF)
Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.
The aim of this clinical trial is to investigate whether pulsatile compression therapy can support heart and kidney function in patients admitted with acute heart failure and fluid accumulation in the legs.
- Trial name
- COMPLEX (NCT07377019)
- Testing
- Pulsatile Compression Boots (PCB)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Anemia, Chronic Kidney Disease
Paricalcitol Effect on Anemia in CKD
Current activated Vitamin D therapies are approved for treating secondary hyperparathyroidism in chronic kidney disease (CKD), and a large body of experimental data in animals confirms the effects of Vitamin D that extend beyond…
- Trial name
- NCT01768351
- Testing
- Paricalcitol, Calcitriol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
End-Stage Renal Disease
Pediatric Kidney Transplant Without Calcineurin Inhibitors
The purpose of this study is to see the effect of using drugs other than calcineurin inhibitors to improve the rate of kidney transplant failure. Kidney transplantation can help children with end-stage kidney disease.
- Trial name
- NCT00023231
- Testing
- Daclizumab, Methylprednisolone/prednisone, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Disease (CKD)
Assessment of Dietary Balance in Home-Dwelling Patients With Stage 4 and 5 Chronic Kidney Disease Using URIKI (IKI), a Connected Urine Test Strip and In Vitro Diagnostic Medical Device
The goal of this clinical trial is to evaluate whether the integration of URIKI, a connected urine test strip and in vitro diagnostic medical device, can improve the nutritional management of patients with stage 4 or 5 chronic…
- Trial name
- URIKI-MRC (NCT07746037)
- Testing
- URIKI Digital Urinary Monitoring System
- Where
- 2 sites in France
- Volunteers
- 450 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Renal Insufficiency
Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency
The purpose of this study is to evaluate the effects of indapamide SR 1.5 mg on renal function, endothelial function, blood pressure variability by comparison with hydrochlorothiazide 25 mg, in patients with Mild to Moderate…
- Trial name
- NCT01172431
- Testing
- Indapamide, Hydrochlorothiazide
- Where
- China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Heart Failure, Asymptomatic Systolic Dysfunction
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
The following are done for screening procedures to determine if patients are eligible for this study: blood count, kidney and liver blood tests. Patients will complete a 6-minute walk test.
- Trial name
- NCT00405639
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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