Clinical trials: Renal Dysfunction
Chronic Kidney Disease
REVEAL-CKD: Prevalence and Consequences of Undiagnosed Chronic Kidney Disease
This is a retrospective, multinational, non-interventional, observational study. A series of cohort studies will be conducted to assess the prevalence of undiagnosed stage 3 CKD in each region.
- Trial name
- REVEAL-CKD (NCT04847531)
- Where
- 13 sites in United States, Australia and 9 more
- Volunteers
- 1,006,361 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Safety and Efficacy of Linagliptin in Type-2-diabetes Mellitus Patients With Moderate to Severe Renal Impairment
The objective of the current study is to investigate the efficacy, safety and tolerability of linagliptin (5 mg / once daily) compared to placebo given over 12 weeks in drug naive or previously treated type 2 diabetic patients…
- Trial name
- NCT01087502
- Testing
- Glimepiride, Linagliptin
- Where
- 52 sites in United States, Australia and 7 more
- Volunteers
- 241 people
- Sponsor
- Boehringer Ingelheim
Chronic Kidney Diseases, Inflammation
Effects of Microencapsulated Propolis and Turmeric in Patients With Chronic Kidney Disease
Oxidative stress and inflammation are correlated with Chronic Kidney Disease (CKD), in a way that they bring several harms to patients, including an increased risk of cardiovascular disease and mortality.
- Trial name
- NCT05183737
- Testing
- Microcapsules with turmeric and propolis
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Universidade Federal Fluminense
Pentoxifylline, Inflammatory Markers
Pentoxifylline on Inflammatory Markers in Non-Diabetic Chronic Kidney Disease Patients
This study aimed to determine the impact of Pentoxifylline on inflammatory biomarkers and the progression of chronic kidney disease in non-diabetic patients.
- Conditions
- Pentoxifylline, Inflammatory Markers, Non-Diabetic, Chronic Kidney Disease
- Trial name
- NCT07315139
- Testing
- Angiotensin-converting enzyme inhibitors (Ramipril), Pentoxifylline
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Acute Kidney Injury, Ventricular Dysfunction
Acute Kidney Injury as a Risk Factor for Myocardial Injury and Ventricular Dysfunction
Acute kidney injury (AKI) is classically described as an abrupt or rapidly reversible reduction in the excretion of nitrogenous waste products, including urea, nitrogen and creatinine.
- Conditions
- Acute Kidney Injury, Ventricular Dysfunction, Myocardium; Injury
- Trial name
- NCT04768751
- Testing
- kidney assessment
- Where
- Egypt
- Volunteers
- 520 people
- Sponsor
- South Egypt Cancer Institute
Acute Kidney Injury
Inferior Vena cavaCollapsibility Index in Patients With Acute Kidney Injury
This is an observational study that will examine the possibility of determining the type of Acute Kidney Injury (AKI) using bedside ultrasound machines.
- Trial name
- NCT02165072
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Tech University Health Sciences Center
Peritoneal Dialysis, Renal Disease, End-Stage
Does Extra-High Dose Hepatitis B Vaccination Confer Longer Serological Protection in Peritoneal Dialysis Patients?
Hepatitis B virus causes inflammation of the liver which is detrimental to the end-stage renal disease patients on dialysis. Hepatitis B vaccine is recommended for this high-risk population although the vaccine protection remains…
- Trial name
- NCT00125775
- Testing
- Engerix-B
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Chinese University of Hong Kong
Acute Kidney Injury (AKI)
The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.
- Trial name
- NCT07602465
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Zhongda Hospital
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Healthy Volunteers
A Phase I Study Comparing the Safety, Pharmacokinetics and Renal Effects of VRP-034 and Marketed Polymyxin B in Healthy Volunteers
This is a Phase 1, single-center, randomized, double-blind, active-controlled clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and nephrotoxicity attenuation potential of VRP-034 compared with…
- Trial name
- VRP-034 (NCT07502144)
- Testing
- VRP-034 (Polymyxin B 500,000 IU), Commercially available Polymyxin B 500,000 IU (Poly-MxB)
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Venus Remedies Limited
End Stage Renal Disease
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease
Frailty and sarcopenia are modifiable risk factors for morbidity and mortality in patients with ESRD. Exercise is the recommended intervention to prevent frailty and sarcopenia, however, many clinical trials have shown limited…
- Trial name
- NCT05422534
- Testing
- CoQ10, HB-HIIT, Observational
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Vanderbilt University Medical Center
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Acute Kidney Injury
Algorithm for Oliguria in Septic Shock
Acute Kidney Injury (AKI) develops in 88% to 30% of critically ill patients admitted to an intensive care unit and is a strong predictor of mortality.Therefore any management strategy that prevents progression of renal risk to…
- Trial name
- AMOSS (NCT02338895)
- Testing
- Ultrasound
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Acute Kidney Failure, Acute Kidney Insufficiency
Kidney Precision Medicine Project
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD.
- Conditions
- Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury
- Trial name
- KPMP (NCT04334707)
- Testing
- Kidney Biopsy, MRI, Retina Scan
- Where
- 13 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Kidney Failure, Chronic
Patient-Provider Trust Among Individuals With End-Stage Kidney Disease
This study will examine communication and trust between patients in the kidney transplant process and their health care providers.
- Trial name
- NCT00075036
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Bone Disorder, Chronic Kidney Diseases
Effect of Active Vitamin D and Etelcalcetide on Human Osteoclasts in Patients With Chronic Kidney Disease
The optimal management of mineral and bone disorders associated to chronic kidney disease (CKD-MBD) is a daily challenge for nephrologists.
- Trial name
- RENOCLASTE (NCT03527511)
- Testing
- Measure of etecalcetide on osteoclastic biology
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
ESRD, Hemodialysis Complication
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis.
- Conditions
- ESRD, Hemodialysis Complication, Blood Pressure
- Trial name
- TAKE-HOLD (NCT03327909)
- Testing
- TAKE vs. HOLD
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Stanford University
Kidney Failure, Graft Rejection
Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients
The purpose of this study is to test two different sirolimus-based immunosuppressive regimens for elderly kidney transplant recipients.
- Conditions
- Kidney Failure, Graft Rejection, Aged
- Trial name
- NCT00254709
- Testing
- Sirolimus
- Volunteers
- 66 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Chronic Kidney Disease
Replication of the DAPA-CKD (Chronic Kidney Disease) Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04882813
- Testing
- Dapagliflozin, Sitagliptin
- Where
- United States
- Volunteers
- 87,727 people
- Sponsor
- Brigham and Women's Hospital
Nephrectomy, Acute Kidney Injury
Effect of Fluid Regimen on Acute Kidney Injury
Postoperative acute kidney injury (AKI) is an important surgical complication that increases hospital stay and mortality when it occurs after kidney surgery.
- Conditions
- Nephrectomy, Acute Kidney Injury, Fluid Therapy
- Trial name
- NCT06256120
- Testing
- Restrictive, Liberal
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muğla Sıtkı Koçman University
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