Clinical trials: Renal Dysfunction
Acute Renal Failure, Chronic Renal Failure
New Non-invasive Methods for Real-time Monitoring of Organ Function.
Measuring novel proteins in the urine of surgical patients that can be used to diagnose impending acute or chronic renal failure.
- Trial name
- RTMKF (NCT00851851)
- Where
- United States
- Volunteers
- 641 people
- Sponsor
- Washington University School of Medicine
Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study
What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically…
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT), Filter Clotting, Microbubbles
- Trial name
- NCT07005531
- Testing
- Ultrasound-Guided Microbubble Clearance During Circuit Priming
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Red-Cell Aplasia, Pure, Chronic Renal Failure
Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin
The purpose of this study is to assess the incidence of pure red cell aplasia (PRCA [suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production]) among participants with chronic renal failure…
- Trial name
- NCT00210951
- Testing
- No Intervention
- Volunteers
- 4,761 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Kidney Diseases, Type2diabetes
EFFECT SGLT2 INHIBITORS ON CONTRAST MEDIUM INDUCED ACUTE KIDNEY INJURY
Chronic kidney disease and type 2 diabetes mellitus patients are with in high-risk patients in coronary arterial diseases and increasing number of coronary angiography and coronary interventional procedures have been performed in…
- Trial name
- NCT06288529
- Where
- Turkey (Türkiye)
- Volunteers
- 975 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Impaired Renal Function
Longterm Follow-up After Remote Ischemic Preconditioning for Prevention of Contrast-induced Nephropathy
Remote ischemic preconditioning reduces the incidence of contrast-induced acute kidney injury in patients undergoing elective coronary angiography.
- Trial name
- RenProLong (NCT01760031)
- Testing
- Ischemic preconditioning
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- University of Cologne
Acute Kidney Injury Due to Sepsis
Pharmacokinetics and Safety of TIN816 in Patients With Sepsis-associated Acute Kidney Injury
The purpose of this study was to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) profile and to evaluate the safety and tolerability of TIN816 in hospitalized adult participants in an intensive care setting with a…
- Trial name
- NCT05507437
- Testing
- TIN816 70 mg lyophilisate powder
- Where
- 7 sites in Belgium, France and 3 more
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Kidney Diseases, Kidney Transplant
Safety and Tolerability of Vertebral Bone Marrow-derived Mesenchymal Stem Cells (BM-MSC) in Real World Scenarios of Patients With Chronic Kidney Disease (CKD)
The purpose of this protocol is to treat an intermediate-sized population with chronic kidney disease (CKD) including kidney transplant recipients. The protocol uses allogeneic bone marrow-derived mesenchymal stem cells (MSCs).
- Trial name
- NCT06752577
- Testing
- Allogeneic, vertebral bone marrow-derived mesenchymal stem cells (MSC)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Liver Cirrhosis
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction
Acute upper gastrointestinal bleeding (AUGIB) is a common complication in the decompensated stage of liver cirrhosis, of which approximately 70% is acute variceal bleeding (AVB) caused by portal hypertension.
- Trial name
- NCT07252401
- Testing
- 2-4 mg of terlipressin, 3 mg of somatostatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- General Hospital of Shenyang Military Region
Masked Hypertension, Hypertension
Treatment of Masked Hypertension
To date, most observational and all intervention studies have defined hypertension on the basis of clinic blood pressure (BP). Measurement of BP outside the clinic with home or ambulatory BP provides a better estimate of the risk…
- Conditions
- Masked Hypertension, Hypertension, Chronic Renal Insufficiency
- Trial name
- NCT02142881
- Testing
- Antihypertensive medication intensification, Usual care
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Chronic Kidney Disease
Stress and CKD Among African Americans
The goal of this study is to determine whether experiencing stress from discrimination may increase chronic kidney disease (CKD) progression in African Americans.
- Trial name
- NCT03387319
- Testing
- Racialized Stressful Event Recall, Non-Racialized Stressful Event Recall
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Hyperuricemia, Hypouricemia, Renal
A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease
This is a phase I/II clinical study to evaluate the safety, tolerability, PK, and efficacy of IG3018 tablet in hyperuricemia (HUA) subjects with or without CKD.
- Trial name
- NCT06310967
- Testing
- IG3018
- Where
- 6 sites in Australia, Taiwan
- Volunteers
- 60 people
- Sponsor
- Intelligem Therapeutics Australia Pty Ltd.
Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD)
Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD).
- Conditions
- Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD), Hemodialysis Patients, Volume Overload
- Trial name
- EU-PHASE-HD (NCT07676786)
- Testing
- Observational Assessment
- Where
- 2 sites in Romania
- Volunteers
- 30 people
- Sponsor
- Stefan Lujinschi
Kidney Failure, Acute
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.
- Trial name
- PARACHUTE (NCT00522756)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Lung Transplant; Complications, Acute Kidney Injury
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Complications after lung transplantation are almost ubiquitous, among which postoperative acute renal failure may represent more than 50% of lung transplant patients and require extrarenal purification in 5 to 13% of cases.
- Trial name
- SO-AKI-TP (NCT05836922)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infection, Heart Failure
Prediction of Expected Length of Hospital Stay Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04784351
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Diseases
Early Detection of Chronic Kidney Disease
This retrospective observational study aims to assess the proportion of patients who were appropriately referred from primary care to the nephrology teleconsultation service.
- Trial name
- DetERC-GARRAF (NCT06950151)
- Where
- Spain
- Volunteers
- 345 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FIRST-2.0 China to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions in a Chinese Population.
This is a post-authorization safety study (PASS) to describe the real-world use of finerenone in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2D) in China.
- Trial name
- FIRST-2_CN (NCT07124039)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- China
- Volunteers
- 6,537 people
- Sponsor
- Bayer
Chronic Kidney Disease, Proteinuria
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
- Conditions
- Chronic Kidney Disease, Proteinuria, Children
- Trial name
- FIONA OLE (NCT05457283)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- 151 sites in United States, Argentina and 30 more
- Volunteers
- 100 people
- Sponsor
- Bayer
Chronic Kidney Disease
Correlation of Urinary Kallikrein With Cytokines, Proteinuria and Renal Function in Chronic Renal Disease Patients
Urinary kallikrein excretion is known to increase in patients with nephrotic syndrome and sick cell disease, but decrease in patients with chronic kidney disease or uremia.
- Trial name
- NCT00395005
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Kidney Disease, Kidney Failure
Older Kidney Patient Optimisation Pretransplant
The goal of this clinical trial is to learn if a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve the way older adults are assessed for kidney transplantation.
- Conditions
- Kidney Disease, Kidney Failure, Frailty, Cognitive Impairment
- Trial name
- OK-POP (NCT07419945)
- Testing
- Kidney transplant-specific comprehensive geriatric assessment
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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