Clinical trials: Renal Excretion
Heart Transplantation
L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function
exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal…
- Trial name
- NCT00213915
- Testing
- 12 g of L-arginine glutamate during 6 weeks twice a day
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Hypovolemia During Liver Transplantation, Renal Hypoperfusion During Liver Transplantation
Evaluation of Hemodynamics and Amount of Blood Flowing Through the Kidneys During Liver Transplant by Measuring Some Physiological Substances in Blood and Urines
The purpose of this study is to verify any existing relationship between urinary parameters (such as excretion of sodium, chlorine, urinary partial CO2 pressure [PuCO2]) and general volemic indicators (such as PiCCO, ScvO2, O2…
- Trial name
- NCT01650116
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera di Padova
Critical Illness, Sepsis
Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy
Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock.
- Conditions
- Critical Illness, Sepsis, Acute Kidney Injury
- Trial name
- NCT02611271
- Testing
- Monitoring of antibiotic drug removal
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Congestive Heart Failure
Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure
The study tests the hypothesis that nitric oxide availability is changed in congestive heart failure with regard to the regulation of renal hemodynamics, renal sodium excretion and release of vasoactive hormones.
- Trial name
- NCT00344734
- Testing
- Ng-monomethyl-L-arginine (drug)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Chronic Kidney Disease
Acid-Base Compensation in Chronic Kidney Disease
The purpose of this study is to evaluate changes in urine net acid excretion, blood pressure and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary supplement similar to baking soda.
- Trial name
- ABC (NCT02427594)
- Testing
- Sodium bicarbonate, Controlled diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Renal Failure Chronic Requiring Hemodialysis
Investigation on the Middle Size Molecule Elimination Characteristics of the FXCorDiax 100 in Relation to the FX 100 and the Polyflux 210 H Dialyser
The purpose of the study is to compare clearance and removal rates of phosphate, ß2-microglobulin (ß2-m) and leptin and albumin loss with different dialyser membranes during post-dilution online hemodiafiltration.
- Trial name
- NCT01578421
- Testing
- 4 h online hemodiafiltration (FX 100, Polyflux 210, FXCorDiax)
- Where
- Switzerland
- Volunteers
- 31 people
- Sponsor
- Kantonsspital Aarau
Healthy Subjects
The Acute Effect of Atorvastain on Renal Function in Patients With Type II Diabetes
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium excretion, glomerular filtration rate, tubular function and vasoactive hormones in patients with type II diabetes, not in treatment with…
- Trial name
- NCT00678522
- Testing
- Atorvastatin
- Where
- 2 sites in Denmark
- Volunteers
- 25 people
- Sponsor
- Regional Hospital Holstebro
Chronic Kidney Diseases, Magnetic Resonance Imaging
Material Balance Study of TQ-B3525
A clinical study to investigate the absorption, metabolism and excretion of [14C] TQ-B3525 in Chinese adult male healthy subjects, aiming to quantitatively analyze the total radioactivity in the excreta of male healthy subjects…
- Trial name
- NCT05675202
- Testing
- TQ-B3525
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Type 2 Diabetes Mellitus
Evaluation of Losartan and Perindopril in Blacks Type 2 Diabetics Patients
The aim of this study is to compare the short-term effects of ACEi and angiotensin II receptor blockers on cardiac and renal protection in black type 2 diabetics patients CARE-PLP is a double-arm, double-blind, randomized and…
- Trial name
- CARE-PLP (NCT04222686)
- Testing
- Perindopril Arginine, Losartan Potassium
- Where
- Cameroon
- Volunteers
- 23 people
- Sponsor
- Yaounde Central Hospital
Kidney Transplant
Study Evaluating Cyclosporine Dose Reduction and Cyclosporine Elimination in Chinese Kidney Transplants
Evaluate the incidence of acute rejection at 12 months after transplantation in subjects receiving induction therapy with cyclosporine microemulsion (CsA) and Rapamune followed by CsA dose reduction (Phase I) with subjects…
- Trial name
- NCT00257387
- Testing
- Cyclosporine
- Volunteers
- 120 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Heart Failure
Spot Urinary Analysis to Assess Loop Diuretic Efficiency in Stable Heart Failure
The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical…
- Trial name
- DIPSTICK (NCT02288819)
- Testing
- Weight monitoring, Loop diuretic downtitration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Hasselt University
Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy
The goal of this double-blinded, placebo-controlled, randomized, crossover study is to examine the effect of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on renal hemodynamics and function in patients with…
- Trial name
- Sema-RMA (NCT06555146)
- Testing
- Semaglutide, 0.5 mg/mL
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Bispebjerg Hospital
Heart Failure
Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure
This study has two primary objectives: 1. To compare combination therapy with acetazolamide and low-dose loop diuretics versus high-dose loop diuretics (standard of care) in patients with acute decompensated heart failure at high…
- Trial name
- DIURESIS-CHF (NCT01973335)
- Testing
- Combination therapy with acetazolamide and low-dose loop diuretics, High-dose loop diuretics, Upfront therapy with oral spironolactone
- Where
- 2 sites in Belgium
- Volunteers
- 34 people
- Sponsor
- Hasselt University