Clinical trials: Renal Failure, End Stage
Renal Impairment
Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)
The purpose of this study is to compare plasma and urine PK parameters of MK-3866 between participants with impaired renal function and healthy control participants, to investigate the extent to which MK-3866 is removed from the…
- Trial name
- NCT03259087
- Testing
- MK-3866
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
End Stage Renal Disease
Effect of Icodextrin Solution on Preservation of Residual Renal Function in Patients on Peritoneal Dialysis
Peritoneal dialysis (PD) is an established dialysis modality in patients with end stage renal disease (ESRD). However, there is growing awareness of the deleterious effect of high glucose content in PD solutions on the peritoneal…
- Trial name
- NCT01170858
- Testing
- Icodextrin PD solution, glucose solutions
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Malnutrition, End Stage Renal Disease
Oral Nutritional Supplement on Nutritional and Functional Status, and Biomarkers in Malnourished Hemodialysis Patients.
Malnutrition in hemodialysis patients is frequent and it is associated with a reduction in muscular mass, strength, functional capacity and quality of life, with an increment in inflammatory and oxidative markers, and with a…
- Trial name
- RENACARE (NCT03924089)
- Testing
- Oral nutritional supplement with probiotics, Oral nutritional supplement without probiotics, Dietary recommendations
- Where
- 3 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Chronic Renal Failure, Hip Fracture
Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery
Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an increased risk of cardiovascular comorbidity.
- Trial name
- NCT01837290
- Testing
- dexmedetomidine infusion for premedication, Midazolam, saline infusion
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Hemodialysis, Peritoneal Dialysis
Study of HEC53856 in Patients With Subjects With End-Stage Renal Disease Receiving Dialysis.
To evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of HEC53856 capsules on anemia in subjects with chronic kidney disease on dialysis.
- Trial name
- NCT04925674
- Testing
- HEC53856
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Hyperphosphatemia, End-stage Renal Disease
Study of Individualized Therapy on Hyperphosphatemia in Maintenance Hemodialysis Patients
This study is designed to study and compare the efficacy and cost-effectiveness of individualized phosphate-lowering therapy in comparison with regular guideline-recommended therapy.
- Trial name
- NCT02684643
- Testing
- enhanced individualised therapy, non-enhanced individualised therapy, regular intervention
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Huashan Hospital
End-Stage Renal Disease
Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity
End-stage renal disease is often accompanied by malnutrition due to less appetite, metabolic changes or both. Human immunodeficiency virus-infection may exacerbate the state of malnutrition.
- Trial name
- NCT00687050
- Testing
- peroral high-caloric supplemental nutrition, peroral supplemental nutrition
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Kidney Transplant Rejection, End Stage Renal Disease
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients
The purpose of this study is to evaluate the safety and tolerability of TX200-TR101 and its effects on the donated kidney in living donor kidney transplant recipients.
- Trial name
- STEADFAST (NCT04817774)
- Testing
- TX200-TR101
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 26 people
- Sponsor
- Sangamo Therapeutics
Kidney Failure, Chronic
Randomized Study of Recombinant Human Growth Hormone in Patients on Chronic Hemodialysis or Peritoneal Dialysis
OBJECTIVES: I. Assess the clinical safety and long term effects of recombinant human growth hormone on a defined range of nutritional indices in malnourished chronic hemodialysis and continuous ambulatory peritoneal dialysis…
- Trial name
- NCT00004429
- Testing
- growth hormone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- FDA Office of Orphan Products Development
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
End-stage Renal Disease (ESRD)
Creating a Buttonhole Tunnel Track by Repeated Needling of the AV Fistula on the Same Day in Patients on Hemodialysis.
BACKGROUND: The patients diagnosed with end stage renal disease require dialysis and for that they need to have a vascular access for hemodialysis (HD) placed.
- Trial name
- NCT03989141
- Testing
- Repeated cannulation Buttonhole., Single cannulation Buttonhole.
- Where
- 2 sites in Denmark
- Volunteers
- 43 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
End Stage Renal Disease
Serum iPTH, Calcium and Phosphate, and the Risk of Mortality in Beijing Elderly Hemodialysis Population
Incidence of End Stage Renal Disease (ESRD) amongst elderly patient group is continuously increasing with population aging progressing.
- Trial name
- NCT03261154
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Wenhu Liu
Chronic Kidney Failure
Evaluation of the Biocompatibility of Cartridge Blood Set Versus Standard Blood Line
The primary objective is to collect data to evaluate the biocompatibility of two types of blood circuit, already on the market.
- Trial name
- NCT00804453
- Testing
- Cartridge blood set, Standard blood line
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Vantive Health LLC
End-stage Renal Disease (ESRD), Chronic Kidney Disease
A Comparative Study of Intradialytic vs. Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial
This randomized controlled trial aims to compare the effectiveness of two different timings of physical therapy for individuals undergoing hemodialysis: intradialytic (during dialysis) and pre-dialysis (before dialysis).
- Conditions
- End-stage Renal Disease (ESRD), Chronic Kidney Disease, Hemodialysis Patients, Physical Rehabilitation During Dialysis
- Trial name
- DIAL-PT (NCT07361146)
- Testing
- Physical Therapy Exercise Program
- Where
- Kuwait
- Volunteers
- 72 people
- Sponsor
- Mohammad Arian
End Stage Renal Disease, Thrombosis
Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis
This study evaluates the safety and efficacy of AB023 (xisomab 3G3) in patients with end stage renal disease on chronic hemodialysis. Two dose levels will be evaluated in two cohorts.
- Trial name
- NCT03612856
- Testing
- AB023- Dose 1, AB023-Dose 2
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Aronora, Inc.
Secondary Hyperparathyroidism, End Stage Renal Failure
Quality of Life Change in Patients Undergoing Parathyroidectomy With End-stage Renal Failure
The purpose of this study is to characterize the quality of life change in patients undergoing parathyroidectomy with secondary hyperparathyroidism due to end-stage renal failure.
- Trial name
- NCT06378931
- Testing
- Quality of life progression after parathyroidectomy
- Volunteers
- 80 people
- Sponsor
- Chunling Jiang
Tuberculosis
Tuberculosis (TB) Screening for the Diagnosis of Latent TB in Immunocompromised Populations
The tuberculin skin test (TST) has been the gold standard for diagnosing latent tuberculosis for almost 100 years. While this test performs reasonably well in healthy, non-bacille Calmette-Guerin (BCG) vaccinated populations, it…
- Trial name
- NCT00134342
- Testing
- T-SPOT TB ELISPOT test
- Where
- 2 sites in Canada
- Volunteers
- 203 people
- Sponsor
- University Health Network, Toronto
End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis
Pumpkin Seed Oil as a Nutraceutical for Hemodialysis Patients
Patients with end-stage renal disease (ESRD) on maintenance hemodialysis experience chronic systemic inflammation, oxidative stress, and dyslipidemia, which together drive much of the excess cardiovascular morbidity and mortality…
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis, Inflammation, Oxidative Stress
- Trial name
- NCT07710183
- Testing
- Pumpkin Seed Oil 1000 mg, Standard hemodialysis care
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Al-Mustansiriyah University
End Stage Renal Disease
Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus
The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve cognitive function by having less effect on brain blood flow.
- Trial name
- NCT03413722
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Chronic Renal Disease, Diabetic Foot
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Context and hypothesis: The prevalence of diabetes mellitus keeps going to increase, due to the ageing of the population and the high prevalence of overweight and obesity.
- Trial name
- NEPHROPOD (NCT04100551)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
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