Clinical trials: Renal Failure, End Stage
Fabry Disease
Detection of Fabry Disease in Chronic Renal Failure Patients in Area Provence - Alpes - Côte d'Azur
Fabry disease is a rare genetic disease characterized by an enzyme deficiency, called alpha-galactosidase A, which normally breaks down a lipid, is missing or does not function properly.
- Trial name
- NCT01374997
- Testing
- micromethod from samples taken from blood spots on filter paper
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type 2 Diabetes Mellitus, DM Nephropathy
Effects of Disease Management on Development of End Stage Renal Disease in Type 2 Diabetic Patients With Nephropathy
Disease management using a multidisciplinary team to achieve and maintain optimal metabolic and cardiovascular risk factors control in Type 2 diabetic patients with nephropathy reduces the incidence of end stage renal disease…
- Trial name
- NCT00309127
- Testing
- Multidisciplinary team care
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Chinese University of Hong Kong
Chronic Renal Failure
Safety Study of TRK-820 for Patient With Hemodialysis
The purpose of this study is to observe pharmacokinetics and safety of nalfurafine hydrochloride in patients receiving hemodialysis.
- Trial name
- TRK-820 (NCT01248650)
- Testing
- nalfurafine hydrochloride
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- SK Chemicals Co., Ltd.
End-Stage Renal Disease
Cook Enforcer Post-Market Study
The purpose of this study is to evaluate the performance of the Cook Advance® Enforcer™ 35 Focal-Force PTA Balloon Catheter (or Enforcer balloon) in treating narrowed blood vessels compared to treatment with a conventional…
- Trial name
- NCT03552289
- Testing
- Cook Advance® Enforcer 35 Focal-Force Percutaneous Transluminal Angioplasty (PTA) Balloon Catheter, Conventional angioplasty balloon catheters
- Where
- 5 sites in United States
- Volunteers
- 211 people
- Sponsor
- Cook Research Incorporated
Kidney Failure, Chronic, Drug Resistance
REPEAT Study - Resistance to ErythroPoietin Effectiveness Algorithm Trial
A strategy for optimizing erythropoietin therapy in patients with erythropoietin resistance. A multi-centered, open-label, randomized, controlled trial.
- Trial name
- NCT00319150
- Testing
- erythropoietin
- Where
- 7 sites in Canada
- Volunteers
- 6 people
- Sponsor
- Queen's University
Kidney Failure, Chronic
Darbepoetin Treatment of Anemia in Children With Chronic Renal Failure
This is a study to determine the safety and effectiveness of Darbepoetin (Aranesp) given every 14 to 28 days to treat low red blood cells in children with chronic kidney failure.
- Trial name
- NCT00213291
- Testing
- darbepoetin alfa
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
End Stage Chronic Renal Failure
Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment
Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption.
- Trial name
- PREFDOM (NCT07535320)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Palliative Care, Renal Failure, End-stage
Effects of a Transitional Palliative Care Model on Patients With End-stage Renal Failure
Primary aim: 1. To compare the effects of customary care and an interventional Home-based Palliative Renal Program (HBPRP) for ESRF patients 2.
- Trial name
- ESRF (NCT02139917)
- Testing
- Transitional community based palliative care
- Where
- Hong Kong
- Volunteers
- 76 people
- Sponsor
- The Hong Kong Polytechnic University
Infective Endocarditis, End Stage Renal Disease
Incidence of Infective Endocarditis in End Stage Renal Disease Patients on Hemodialysis by Transesophageal Echocardiography in Assuit University Hospital
1. To detect in more detail the incidence of infective endocarditis in patients with end stage renal disease (ESRD) on hemodialysis. 2.
- Trial name
- NCT05692089
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Chronic Kidney Failure, Acute Kidney Failure
Theranova Randomized, Controlled, Trial (RCT) in China
Traditional hemodialysis (HD) therapy is very effective in clearing urea and smaller middle molecules, but is limited in clearing larger middle molecules.
- Trial name
- ROCKet (NCT05309291)
- Testing
- Theranova 400 Dialyzer, FX 800 Dialyzer
- Where
- 10 sites in China
- Volunteers
- 323 people
- Sponsor
- Vantive Health LLC
End Stage Renal Failure on Dialysis
Theranova vs High-flux HD Comparison
This research proposal of an investigator-initiated clinical study aims to examine the impact of uremic toxin removal afforded by middle cut-off (MCO) dialysis on clinical parameters and surrogate biomarkers pertinent to…
- Trial name
- NCT04106310
- Testing
- High-flux dialyzer, Theranova dialyzer
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
End Stage Renal Disease
A Study to Evaluate the Safety and Efficacy of Paricalcitol Capsules in Reducing Serum Intact Parathyroid Hormone Levels in End Stage Renal Disease Subjects on Peritoneal Dialysis
To determine the safety and efficacy of paricalcitol capsules as compared to placebo for treatment of secondary hyperparathyroidism by decreasing serum intact parathyroid hormone levels in end stage renal disease subjects on…
- Trial name
- NCT00646035
- Testing
- paricalcitol capsules
- Where
- 24 sites in United States, Poland
- Volunteers
- 75 people
- Sponsor
- Abbott
End Stage Renal Disease, Cardiovascular Diseases
Comparison of MCO HD on Markers of Vascular Health Compared With On-Line Haemodiafiltration
The aim of this study is to evaluate haemodialysis treatment using a medium cut-off dialysis membrane (Theranova) compared with on-line haemodiafiltration treatment with respect to markers of endothelial health (plasma…
- Conditions
- End Stage Renal Disease, Cardiovascular Diseases, Inflammation
- Trial name
- MoDal (NCT03510520)
- Testing
- Medium Cut-Off Haemodialysis, On-Line Haemodiafiltration
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Manchester University NHS Foundation Trust
Renal Failure
Comparing Everolimus and Sirolimus in Renal Transplant Recipients
This study is being done to compare the effectiveness and safety of two different kidney transplant immunosuppression drugs, Zortress (the study drug) and Rapamune (which is used in the current standard immunosuppression regimen).
- Trial name
- NCT01976390
- Testing
- Everolimus, Sirolimus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Chronic Kidney Failure, Inflammation
Vascular Calcification's Risk Factors in Haemodialysis Patients
A not randomized , cross sectional study will be done to determine the possible association of coronary artery calcification (CAC) score assessed by multirow spiral computed tomography (MSCT) with specific and non specific uremic…
- Conditions
- Chronic Kidney Failure, Inflammation, Vascular Calcification
- Trial name
- NCT00694824
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
End Stage Renal Disease
Trial to Evaluate Safety and Tolerability of Tacrolimus Extended-Release (Astagraf XL) in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
The purpose of this study is to demonstrate the safety of tacrolimus extended-release in HLA sensitized (HS, defined as panel reactive antibody ≥ 30%), kidney transplant recipients after desensitization with intravenous…
- Trial name
- NCT03194321
- Testing
- Tacrolimus Extended-Release Oral Capsule
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
End Stage Renal Disease
Effect of Changes in Dialysate Bicarbonate on Serum Calcification Propensity and Calciprotein Particles in Hemodialysis Patients
This is a single-center, prospective, proof-of-priciple, pilot study in 24 end-stage renal disease patients on chronic hemodiaysis.
- Trial name
- D-Bic-T50-HD (NCT06084858)
- Testing
- Dialysate bicarbonate modification
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Prim. Priv. Doz. Dr. Daniel Cejka
End-Stage Renal Disease (ESRD)
Aluminum and Auditory Function in ESRD
Hearing impairment either clinical or subclinical is a characteristic of some renal disease patients. The hearing impairment could be result from specific etiologies or chronic renal failure itself.
- Trial name
- NCT00243958
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Kidney Failure, Chronic, End-Stage Renal Disease
Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)
The purpose of this study is to perform a randomized, controlled clinical trial to investigate if the phosphate binder sevelamer can improve insulin resistance and glucose handling in patients receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Chronic, End-Stage Renal Disease, Insulin Resistance, Hyperphosphatemia
- Trial name
- SIR (NCT00837655)
- Testing
- Sevelamer, Calcium carbonate
- Where
- 2 sites in Sweden
- Sponsor
- Karolinska Institutet
End-stage Renal Disease (ESRD)
A Study of Safety, PK, & PD of ISIS 416858 Administered Subcutaneously to Patients With End-Stage Renal Disease on Hemodialysis
Evaluation of safety, tolerability, PK and PD of ISIS 416858 in patients with end-stage renal disease (ESRD) receiving chronic hemodialysis.
- Trial name
- NCT02553889
- Testing
- ISIS 416858
- Where
- 8 sites in Canada
- Volunteers
- 49 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
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