Clinical trials: Renal Failure, End Stage
Chronic Renal Failure, Healthy Controls
Gender Differences in Renal Functioning and Disease
The purpose of the GenderBOLD study is to shed light on the mechanisms responsible for women's lower susceptibility to developing and progressing chronic renal disease, using modern imaging techniques, and applying different…
- Trial name
- GenderBOLD (NCT04085094)
- Testing
- high-salt diet (V1) and low salt diet (V2), Contrast-enhanced ultrasound (CEUS), functional MRI
- Where
- Switzerland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
End Stage Renal Disease
Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation
Kidney transplantation (KT) requires a life-long immune suppression (IS). It has been well-known that long-term IS inevitably causes various complication e.g.
- Trial name
- NCT02199301
- Testing
- Transplantation Conditioning for BMT
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Samsung Medical Center
Cardiovascular Diseases, Heart Diseases
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Kidney Failure, Chronic
- Trial name
- NCT00005536
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
End Stage Renal Disease, Peritoneal Dialysis-associated Peritonitis
A Prospective Clinical Study to Assess the Clinical Utility of Turbidity in Patients Using In-Home Peritoneal Dialysis
This study aims to determine if the CloudCath device can detect infections related to peritoneal dialysis (peritonitis) as fast or faster than the current standard methods used by patients and doctors to detect such infections.
- Conditions
- End Stage Renal Disease, Peritoneal Dialysis-associated Peritonitis, Peritonitis
- Trial name
- ACT (NCT05285436)
- Testing
- CloudCath System
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- CloudCath
End-Stage Kidney Disease
Evaluate the Survival Benefits of Zemplar Versus Calcijex in Subjects w/ Stage V Chronic Kidney Disease on Hemodialysis
To evaluate the survival benefit associated with Zemplar therapy as compared to Calcijex for the treatment of secondary hyperparathyroidism in subjects with Stage V chronic kidney disease on hemodialysis as measured by time to…
- Trial name
- NCT00062699
- Testing
- Zemplar (paricalcitol injection), Calcijex
- Where
- 60 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- Abbott
Chronic Kidney Failure
Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function
Weight loss commonly occurs in patients with chronic kidney disease (CKD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01890811
- Testing
- Boost High Protein
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas A&M University
Chronic Kidney Disease
Observational Study of Kibow Biotics in Chronic Kidney Failure Patients on Dialysis
A specifically formulated probiotic product comprised of defined and tested microbial strains may afford renoprotection in what has been generally called "Enteric DialysisTM".
- Trial name
- NCT01450709
- Testing
- Kibow Biotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kibow Pharma
Chronic Kidney Diseases
Kidney AI-enabled Care Transformation
In the Kidney ACTion study, CKD (Chronic Kidney Disease) patients at increased risk of progression to ESRD (End Stage Renal Disease) will be randomly assigned to either standard of care in a specialist nephrology outpatient…
- Trial name
- NCT05056909
- Testing
- Kidney ACTion, Standard of care
- Where
- 2 sites in Italy, United Kingdom
- Sponsor
- Medical University of Graz
Chronic Kidney Failure, Chronic Kidney Diseases
Physical Impairments in Children With Chronic Renal Failure
When the literature is examined, it is seen that the extent to which cough strength, grip strength, physical activity level and quality of life levels are affected in children with chronic kidney failure compared to healthy…
- Trial name
- NCT06981585
- Testing
- Physical Evaluations of Patients with Chronic Kidney Failure, Physical Evaluations of Healthy Children
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Kidney Failure, Chronic, Olfaction Disorders
Taste And Smell TEsting in End Stage Renal Disease
Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status.
- Conditions
- Kidney Failure, Chronic, Olfaction Disorders, Taste Disorders, Malnutrition
- Trial name
- TASTE ESRD (NCT03043144)
- Testing
- Worsening of olfaction from enrollment visit to 6 months, Worsening of taste from enrollment visit to 6 months, Serum Zinc
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Type 2 Diabetes, End Stage Renal Disease
Using Sitagliptin as a Treatment to Prevent New Onset Diabetes After Kidney Transplantation
This study is designed to see if the use of the drug Sitagliptin (used to reduce insulin resistance) will delay or prevent kidney transplant patients from getting diabetes.
- Trial name
- NCT00936663
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Nebraska
End Stage Kidney Disease, Immunological Tolerance
Immunological Tolerance in Patients With Mismatched Kidney Transplants
This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05806749
- Testing
- Donor CD34+, CD3+. and belumosudil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
End-stage Renal Disease
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
By 2030 an estimated 2 million people in the US will need dialysis or transplantation. Insulin resistance and chronic inflammation are common in dialysis patients and have been linked to protein-energy wasting, the most important…
- Trial name
- SummerMRI (NCT04067752)
- Testing
- high dialysate sodium concentration (138 mEq/L), Low dialysate sodium concentration
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
End Stage Renal Disease
Protein Supplementation in Dialysis Patients
The mortality rate in chronic hemodialysis (CHD) patients remains excessively high and approaches 21% per year. Among the many factors that adversely affects patient outcome is uremic malnutrition, a unique form of deranged…
- Trial name
- NCT00367198
- Testing
- Pro-Stat
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
End Stage Renal Disease (ESRD)
Product Evaluation for the Effectiveness of the ClearGuard® HD End Cap
To assess blood stream infections in participants using two FDA-cleared devices: ClearGuard HD end caps compared to the Tego® connector with the CurosTM for Tego disinfecting port protector.
- Trial name
- NCT02593149
- Testing
- ClearGuard HD End Cap
- Where
- United States
- Volunteers
- 1,902 people
- Sponsor
- Pursuit Vascular, Inc.
Chronic Kidney Diseases
Determinants of Vascular Calcification in Chronic Renal Failure : Impact of Pyrophosphate Levels After Renal Transplantation
Arterial calcifications (AC) are constant lesions in patients with Chronic Kidney Diseases (CKD). Renal transplantation would reduce their progression compared to dialysis.
- Trial name
- PyroCal-greffe (NCT03462238)
- Testing
- Blood collection for Ppi assay, CT Scan
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
End Stage Renal Disease, Fatigue
Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis
Fatigue is the most common symptom reported by end-stage kidney disease patients on maintenance hemodialysis. Unfortunately, there currently is no medical management for this overwhelming feeling of tiredness.
- Trial name
- BRISK (NCT06609343)
- Testing
- Bupropion Hydrochloride 150 MG
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Kidney Failure, Chronic
Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist
This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of…
- Trial name
- NCT02895243
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Kidney Failure, Chronic, Renal Disease, End-Stage
Pharmacokinetics/Pharmacodynamics of Argatroban Injection in End-Stage Renal Disease Patients Undergoing Hemodialysis
The primary goals of this investigation are to provide guidance on how to dose Argatroban in patients undergoing hemodialysis and to assess the safety and tolerability of Argatroban in hemodialysis patients.
- Trial name
- NCT00035178
- Testing
- Argatroban
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Texas Biotechnology Corporation
End Stage Renal Disease (ESRD), Brachiocephalic Fistula (BCF)
Outcome of BCF Access in Hemodialysis Patients
Dialysis access, which is the connection that allows blood to flow in and out of the body during dialysis sessions, is important to remove wastes and excess fluid for patients with end stage renal disease (ESRD).
- Conditions
- End Stage Renal Disease (ESRD), Brachiocephalic Fistula (BCF), Cephalic Arch Stenosis (CAS), Dialysis
- Trial name
- BCF (NCT01693263)
- Testing
- brachiocephalic fistula (BCF)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
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