Clinical trials: Renal Function
Kidney Transplant, Delayed Graft Function
Tacrolimus to Sirolimus Conversion for Delayed Graft Function
The objective of this study is to evaluate the safety and efficacy of conversion from tacrolimus to sirolimus early after kidney transplantation in patients with delayed graft function (DGF)and slow graft function (SGF) in…
- Trial name
- RAPA (NCT00931255)
- Testing
- Tacrolimus, Sirolimus
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Maryland, Baltimore
Left Ventricular Diastolic Dysfunction
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
The purpose of this research study is to evaluate the effects of cardiac hormone replacement with SQ (subcutaneous or under the skin) injection of BNP (brain natriuretic peptide, a hormone produced by the heart) on the pumping…
- Trial name
- NCT00405548
- Testing
- BNP (nesiritide)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2, Diabetic Nephropathies
Renoprotective Effects of Dapagliflozin in Type 2 Diabetes
Background: Worldwide, diabetic nephropathy or Diabetic Kidney Disease (DKD), is the most common cause of chronic and end-stage kidney disease.
- Trial name
- RED (NCT02682563)
- Testing
- Dapagliflozin 10mg QD, Gliclazide 30mg QD
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- M.H.H. Kramer
Anesthesia, Liver Functions
The Effects of Low Flow and Normal Flow Desflurane Anesthesia
Aging is a physiological process. In the elderly, loss of functional reserve in all organ system, regression in anabolic processes and increase in catabolic processes are observed s (1).
- Conditions
- Anesthesia, Liver Functions, Kidney Functions, Geriatric
- Trial name
- NCT05414721
- Testing
- Low flow desflurane anesthesia (Group D)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Renal Transplantation
Influence of Sirolimus and MMF on Vascular Function and Markers of Cellular Function in Renal Transplant Recipients
Chronic transplant nephropathy and cardiovascular death are the main reasons for loss of transplanted organs after kidney transplantation.
- Trial name
- NCT00204321
- Testing
- sirolimus (drug), mmf (drug)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Muenster
Urethral Obstruction
Standardized Prenatal Clinical Care for LUTO
The investigators propose a standardized prenatal management, based on the scientific evidence published in the literature, to manage prenatally fetuses with lower urinary tract obstruction (LUTO).
- Trial name
- NCT02315521
- Testing
- Fetal Intervention for LUTO
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Osteoporosis
The Relationship Between the Residual Renal Function and Osteoporosis Treatment
The relationship between osteoporosis drugs and kidney damage is unclear. In this study, we plan to reveal relationship between osteoporosis drugs and kidney damage.
- Trial name
- NCT02304887
- Testing
- Bis, SERM Teriparatide, Denosumab
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Toshihiko Kono
Autosomal Dominant Polycystic Kidney Disease
Tolvaptan-Octreotide LAR Combination in ADPKD
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a leading cause of End Stage Kidney Disease (ESKD) worldwide. Elevated levels of 3', 5' - cyclic AMP (cAMP) play a central role in the pathogenesis and progression of the…
- Trial name
- TOOL (NCT03541447)
- Testing
- Tolvaptan, Octreotide LAR
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Fluid Overload, Fluid Loss
Peroperative Fluid Management in Major Gynecological Cancer Surgeries
The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries.
- Conditions
- Fluid Overload, Fluid Loss, Perioperative/Postoperative Complications, Acute Kidney Injury
- Trial name
- NCT06101498
- Testing
- Akut kidnet injury(AKI)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Chronic Disease, Kidney Diseases
A Study to Evaluate Whether Correction of Anemia Using Recombinant Human Erythropoietin Reduces the Progression of Atherosclerosis and Cardiac Hypertrophy in Pre-dialysis Chronic Kidney Disease Patients
The primary aim of the study is to evaluate the effects of correction of anemia using erythropoietin on the progression of atherosclerosis and cardiac muscle thickening in patients with chronic kidney disease
- Conditions
- Chronic Disease, Kidney Diseases, Cardiovascular Diseases
- Trial name
- NCT00563355
- Testing
- erythropoietin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Hospital Authority, Hong Kong
Hepatic Insufficiency, Renal Insufficiency
Study of Copanlisib in Hepatic or Renal Impairment
To evaluate the pharmacokinetics and safety of copanlisib in subjects with impaired hepatic or renal function in comparison to healthy subjects
- Trial name
- NCT03172884
- Testing
- Copanlisib (ALIQOPA, BAY80-6946)
- Where
- 2 sites in Germany, Romania
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bayer
Renal Function Disorder, Glucose Metabolism Disorders
Phthalates Exposure in Type 2 Diabetic Patients and Diuretic Therapy
In this open clinical trial, 30 subjects with inadequately controlled T2D and eligible, as per good clinical practice, for therapy with SGLT-2 inhibitor, will be randomized to receive a SGLT-2 inhibitor vs other oral-antidiabetic…
- Trial name
- PURITY (NCT04242758)
- Testing
- Dapagliflozin 10 MG, Hydrochlorothiazide 12.5mg
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pisa
Renal Insufficiency, Kidney Diseases
Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB054707 in Participants With Normal and Impaired Renal Function and Participants on Hemodialysis
This is a multi-center, open-label, parallel-group study to evaluate oral doses of INCB054707 in participants with varying levels of renal function or impairment.
- Trial name
- NCT05624723
- Testing
- INCB054707
- Where
- 2 sites in United States, Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Liver Transplantation
RESCUE Study - Everolimus in Liver Transplantation Recipients With Renal Insufficiency
The purpose of the study is to assess the effect of everolimus initiation together with reduction or discontinuation of calcineurin inhibitor (CNI) on renal function in maintenance liver transplant recipients with CNI-related…
- Trial name
- NCT00267189
- Testing
- Everolimus, Calcineurin inhibitors (CNI), Mycophenolate acid (MPA)/ Azathioprine (AZA)
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 145 people
- Sponsor
- Novartis Pharmaceuticals
Renal Transplant
Absence of Steroid in Renal Transplantation and Digital Fibrosis Observation
The main objective of this study is to demonstrate that the absence of post-transplantation corticosteroids does not induce a larger increase of renal graft fibrosis (by numerical reading) on biopsy at one year…
- Trial name
- Astronef (NCT01541176)
- Testing
- Absence of corticotherapy post-transplantation, Corticotherapy post-transplantation
- Where
- 8 sites in France
- Volunteers
- 193 people
- Sponsor
- Nantes University Hospital
Contrast Induced Nephropathy
Contrast Agent-associated Nephrotoxicity in Intensive Care Unit Patients
The use of N-acetylcysteine and ascorbic acid reduce the incidence of radiographic contrast agent induced reduction in renal function in Intensive Care Unit patients.
- Trial name
- ICU (NCT01017796)
- Testing
- N-acetylcysteine and ascorbic acid
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Metastatic Renal Cell Cancer, GIST
Evaluation of Cognitive Function of Patients With Sunitinib or Sorafenib
Patients with advanced kidney cancer or GIST (Gastro Intestinal Stromal Tumor: this is a tumor of the intestines) may be eligible for treatment with one of the following drugs: sunitinib (Sutent ®) or sorafenib (Nexavar ®).
- Trial name
- NCT01246843
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Kidney Function Tests
Effect of Hydroxyethylstarch 6% 130/0.4 Administration on Renal Function After Cardiac Surgery
Recent studies have shown an increased incidence of renal replacement therapy after the use of Hydroxyethylstarchs (HES) in patients admitted in the intensive care unit.
- Trial name
- NCT02306213
- Testing
- Hydroxyethylstarch 6% 130/0.4, standard volume therapy
- Volunteers
- 1,564 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Kidney Diseases
Steroid Withdrawal in Pediatric Renal Transplant Recipients Under Cyclosporine (CyA) and Mycophenolate Mofetil (MMF)
The present study investigates the safety and efficacy of steroid withdrawal in pediatric renal transplant recipients with stable graft function under concomitant immunosuppression with cyclosporine and mycophenolate mofetil.
- Trial name
- NCT00309218
- Testing
- methylprednisolone
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Klinik für Kinder- und Jugendmedizin
Chronic Kidney Diseases
Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients
Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular death.
- Trial name
- NCT06286748
- Testing
- Beetroot juice
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal Fluminense