Clinical trials: Renal Function, open to volunteers
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Renal Transplantation, Dexmedetomidine
Dexmedetomidine and Kidney Transplantation
Dexmedetomidine, an alpha 2 agonist, is being increasingly used in recent years for the maintaining of anesthesia as it allows sedation and analgesia with only a modest respiratory depression effect when compared to opioids and…
- Trial name
- DexTR (NCT05935293)
- Testing
- Dexmedetomidine
- Volunteers
- 206 people
- Sponsor
- Eduardo Schiffer
Chronic Kidney Disease, Nephrolithiasis
Kidney Sodium Functional Imaging
The corticomedullary gradient is largely responsible for developing the gradients that are needed to concentrate urine (more solutes and less water).
- Conditions
- Chronic Kidney Disease, Nephrolithiasis, ADPKD
- Trial name
- NCT05014178
- Testing
- Sodium-23 MRI
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Renal Impairment, Healthy
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function
The purpose of this study is to learn how the study medicine PF-07328948 is processed by the body and how safe and tolerable it is in adults with different levels of kidney function.
- Trial name
- NCT07315360
- Testing
- PF-07328948
- Where
- 4 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Delayed Graft Function
TxAccess and Dd-cfDNA for Improved Care of Patients With Delayed Graft Function
This is a prospective multicenter nonrandomized pragmatic hybrid effectiveness-implementation study to test the effectiveness of TxAccess in improving time to renal recovery and immunologic outcomes in patients with delayed graft…
- Trial name
- NCT07825688
- Testing
- TxAccess, Donor-Derived Cell-Free DNA (dd-cfDNA)
- Volunteers
- 450 people
- Sponsor
- Duke University
AOD Prescription
Impact of Renal Function Availability to Community Pharmacist for Dispensing Direct Oral Anticoagulant in Ambulatory Patients on Bleeding Occurrence
The use of direct oral anticoagulants (AODs) in the prevention and treatment of thromboembolic diseases is increasing, with a favorable benefit/risk balance and improved quality of life for patients.
- Trial name
- Hemorrag-IR (NCT06739603)
- Testing
- pharmaceutical analysis
- Volunteers
- 1,920 people
- Sponsor
- Université de Reims Champagne-Ardenne
Hemodialysis, Kidney Disease, Chronic
Intradialysis Exercise Functional Capacity, Body Composition and Survival in Hemodialysis Patients
Chronic kidney disease and renal replacement treatments (hemodialysis, peritoneal dialysis, kidney transplant) produce various alterations at the level of muscle, bones, fat content and the heart; can alter physical capabilities…
- Conditions
- Hemodialysis, Kidney Disease, Chronic, Physical Activity, Physical Deconditioning
- Trial name
- NCT06788054
- Testing
- intradialysis exercise
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Universidad de Guanajuato
Diabetic Kidney Disease
Effect of Chinese Herbal Medicine on Renal Function in Diabetic Kidney Disease
This study is a randomized controlled pilot trial designed to evaluate the effects and safety of a traditional Chinese medicine formula (DKD-1) as an add-on therapy to standard treatment in patients with Diabetic Kidney Disease…
- Trial name
- NCT07657351
- Testing
- Chinese herbal formula DKD-1
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- China Medical University Hospital
Acute Kidney Injury, Renal Insufficiency
A Methodological Study to Learn More About Kidney Function in Healthy People and in People With Reduced Kidney Function
The main purpose of this study is to investigate how reliable a test assessing the renal functional reserve (RFR) and the maximum glomerular filtration rate (maxGFR) are.
- Trial name
- NCT07368712
- Testing
- No investigational study intervention
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Bayer
CKD - Chronic Kidney Disease, Renal Function
Walnuts for Cardiorenal Protection in Adults With Chronic Kidney Disease
To date, no rigorous randomized controlled trials have demonstrated a protective effect of daily moderate walnut consumption on kidney function or chronic kidney disease (CKD) progression in individuals with CKD.
- Conditions
- CKD - Chronic Kidney Disease, Renal Function, Cardiovascular Biomarkers
- Trial name
- NutReCard (NCT07851454)
- Testing
- Daily Walnut Consumption
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Renal Impairment, Healthy Volunteers
Study to Assess the Plasma Concentration of Rilzabrutinib Given as a Tablet to Adult Participants With Severe Renal Impairment Compared to Matched Participants With Normal Renal Function
The purpose of this Phase 1, open-label, 2-arm study is to assess the effect of severe RI on PK, safety, and tolerability of rilzabrutinib compared with normal renal function, in male and female participants aged from 18 to 75…
- Trial name
- NCT07853131
- Testing
- rilzabrutinib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Peritoneal Dialysis Complication, Renal Function Aggravated
Dapagliflozin Delays the Loss of Renal Function in Peritoneal Dialysis Patients
This study aims to explore the role of dagliflozin in preserving the residual renal function(RRF) in peritoneal dialysis (PD) patients.
- Conditions
- Peritoneal Dialysis Complication, Renal Function Aggravated, Sodium-glucose Co-transporter-2 Inhibitors
- Trial name
- NCT06398977
- Testing
- Dapagliflozin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Sichuan Academy of Medical Sciences
Chronic Kidney Disease
Nicotinamide Riboside Supplementation in Chronic Kidney Disease
This study is testing whether a dietary supplement called nicotinamide riboside, (NR), can be used in adults with moderate chronic kidney disease. NR is a form of vitamin B3 that may help support cellular energy metabolism.
- Trial name
- NR-CKD (NCT07693543)
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Type 2 Diabetes Mellitus, Type 2 Diabetes With Chronic Kidney Disease
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background…
- Trial name
- Eluminate-4 (NCT07662135)
- Testing
- Elecoglipron
- Where
- 186 sites in United States, Bulgaria and 14 more
- Volunteers
- 900 people
- Sponsor
- AstraZeneca
Kidney Transplant Failure and Rejection, Transplantation, Kidney
To Explore the Application Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function and Systemic Metabolism After Renal Transplantation
At present, renal biopsy is the gold standard for evaluating the pathology of renal transplants, but it is invasive and has the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Conditions
- Kidney Transplant Failure and Rejection, Transplantation, Kidney, Kidney Transplant Dysfunction
- Trial name
- NCT07145944
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Blood Pressure, Hydration
Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)
Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States.
- Conditions
- Blood Pressure, Hydration, Vascular Disease Risk
- Trial name
- PHACKs (NCT06062017)
- Testing
- Water and Potassium supplementation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Auburn University
Cystic Fibrosis (CF), Chronic Kidney Disease(CKD)
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it…
- Conditions
- Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
- Trial name
- NCT06595420
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Kidney Diseases
Comparison of the Effects of Belatacept and Anticalcineurins on Endothelial Function in Renal Transplant Patients - <BELAFENDO>
Kidney transplantation is the standard treatment for patients with end-stage renal failure. However, anticalcineurin inhibitors, the most widely used immunosuppressants, are involved in the occurrence of cardiovascular events, a…
- Trial name
- BELAFENDO (NCT06291077)
- Testing
- Belatacept, anticalcineurins
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Rouen
Kidney Neoplasms / Surgery, Glomerular Filtration Rate
The Study on the Effectiveness of [68Ga]Ga-HBED-CC-DiAsp PET/CT in Calculating GFR and Predicting Residual Renal Function After Partial Nephrectomy
In subjects with different levels of renal function and no history of renal tumors, GFR is measured using [68Ga]Ga-HBED-CC-DiAsp PET/CT, the Gates method, and the 99mTc-DTPA dual plasma method.
- Conditions
- Kidney Neoplasms / Surgery, Glomerular Filtration Rate, Positron-Emission Tomography(PET)
- Trial name
- NCT06973798
- Testing
- GFR will be measured using three methods at two weeks before surgery and four ± one week after surgery, GFR will be measured using three methods: [68Ga]Ga-HBED-CC-DiAsp PET/CT, the Gates method, and the dual plasma sampling method with 99mTc-DTPA.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Luo Yaping
Chronic Kidney Diseases, Acute Kidney Injury
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression
Chronic kidney disease CKD is estimated to affect nearly over 800 million people globally today (with roughly 125,000 people ending up annually on dialysis in the United States alone.
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Kidney Failure
- Trial name
- NAD agent (NCT06866236)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Ebima Clifford Okundaye