Clinical trials: Renal Impairment
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Chronic Kidney Disease
Peer-mentoring, Quality of Life and Caregiver Burden in Patients With Chronic Kidney Disease and Their Caregivers
Receiving supportive mentoring from well-adjusted individuals who share similar experiences has had a positive influence on adjustment with some chronic diseases.
- Trial name
- NCT02429115
- Testing
- Mentoring
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Acute-On-Chronic Liver Failure, Renal Failure
Cytokine Adsorption in Acute-on-chronic Liver Failure
The CYTOHEP study is a prospective, randomized, single center, open-label, controlled intervention trial to assess the benefit of extracorporeal hemoadsorption using the CytoSorb device in patients with acute-on-chronic liver…
- Trial name
- CYTOHEP (NCT05019352)
- Testing
- CytoSorb cytokine adsorber, CRRT
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- Dr. Alexander Supady
Chronic Kidney Diseases
Chronic Kidney Disease - REAL Life Study in Alsace
Chronic kidney disease (CKD) is a public health problem and affects about 10% of the world's adult population with a constantly increasing incidence.
- Trial name
- CKD-REAL (NCT05527626)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Strasbourg, France
Hypogonadism, Male, Kidney Disease, Chronic
Testosterone Treatment in Men With Chronic Kidney Disease
This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood…
- Trial name
- NCT05249634
- Testing
- Jatenzo Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Hyperkalaemia, Chronic Kidney Disease
Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Study
This is an open-label, randomised study in participants with chronic kidney disease (CKD) treated for hyperkalaemia (HK) whilst in hospital.
- Trial name
- CONTINUITY (NCT05347693)
- Testing
- Sodium Zirconium Cyclosilicate (SZC), Local standard of care
- Where
- 28 sites in Belgium, France and 4 more
- Volunteers
- 186 people
- Sponsor
- AstraZeneca
Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
The exact role of urinary tract infection in the appearance of chronic kidney disease is unclear. Children with congenital malformations of kidney and urinary tract have the higher risk of impairment of renal function.
- Conditions
- Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, Chronic Kidney Disease
- Trial name
- PREDICT (NCT02021006)
- Testing
- nitrofurantoin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 292 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Kidney Diseases, Hypertension
Electronic Tools to Increase Recognition and Improve Primary Care Management for Hypertension in Chronic Kidney Disease
In this project the investigators will create computer reminders through user-centered design and will validate the logic using retrospective electronic health record (EHR) data.
- Trial name
- NCT03679247
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 2,026 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Chronic Kidney Diseases
Intravascular Ultrasound-Guided PCI in Patients With Chronic Kidney Disease
The IVUS-CKD study is a prospective, randomized controlled, multicenter trial to determine whether the intravascular ultrasound (IVUS)-guided percutaneous coronary intervention is superior to the angiography-guidance in chronic…
- Trial name
- IVUS-CKD (NCT06567938)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,528 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pharmacokinetics of Vepoloxamer, Healthy Volunteers
Study of the Effect of Renal Impairment on the Pharmacokinetics of Vepoloxamer
This is an open-label study designed to evaluate the effect of renal disease on the pharmacokinetics of vepoloxamer relative to the pharmacokinetics in healthy subjects with normal renal function.
- Conditions
- Pharmacokinetics of Vepoloxamer, Healthy Volunteers, Renal Impaired
- Trial name
- NCT02646358
- Testing
- Vepoloxamer
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Mast Therapeutics, Inc.
Peritonitis, Catheter-related Infections
Taurolock for Preventing Bacterial Peritonitis During Renal Insufficiency
Dialysis catheters are sites of bacterial proliferation. The purpose of this study is to determine whether or not the use of Taurolock (a catheter lock solution) can prevent bacterial peritonitis in patients undergoing peritoneal…
- Conditions
- Peritonitis, Catheter-related Infections, Renal Insufficiency
- Trial name
- NCT01101087
- Testing
- Taurolock
- Where
- 15 sites in France, French Polynesia
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Acute Kidney Injury Due to Sepsis
Renin Angiotensin Aldosterone System In Septic Kids
Prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with acute kidney injury (AKI) vs without AKI.
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Acute Kidney Injury (Nontraumatic)
- Trial name
- RISK (NCT06295393)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Hyperkalemia, Chronic Kidney Disease (Stage 3-4)
AK+ Guard™ Pilot Study in Chronic Kidney Disease: Outpatient Diagnostic Accuracy and Remote Monitoring
The goal of this observational pilot study is to evaluate the investigational AK+ Guard™ software as a medical device (SaMD) for detection of moderate to severe hyperkalemia (serum potassium (K+) ≥ 6.5 mmol/L) in adults with…
- Trial name
- NCT07210021
- Testing
- AK+ Guard™ ECG Application
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AccurKardia, Inc.
ESRD, Hemodialysis
Use of a Lifeline Graft in the A-V Shunt Model
This study will assess the safety and efficacy of a completely autologous and completely biological tissue engineered blood vessel (TEBV) called Lifeline™ used as an arteriovenous fistula for dialysis access.
- Trial name
- NCT00850252
- Testing
- Lifeline
- Where
- 2 sites in Argentina, Poland
- Sponsor
- Cytograft Tissue Engineering
Acute Kidney Injury, Dexmedetomidine
The Effect of Dexmedetomidine on Kidney Function in EVAR
This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia
- Conditions
- Acute Kidney Injury, Dexmedetomidine, Endovascular Aortic Repair
- Trial name
- DEVAR (NCT04766047)
- Testing
- Dexmedetomidine
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Inflammatory Disease
Pharmacokinetics of Lanraplenib in Adults With Impaired Renal Function
The primary objective of this study is to evaluate the pharmacokinetics (PK) of lanraplenib in participants with impaired renal function relative to matched healthy controls.
- Trial name
- NCT02959138
- Testing
- Lanraplenib.
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Chronic Kidney Disease, Hypertension
Potassium Intake in Patients With Chronic Kidney Disease
Chronic kidney disease is associated with high blood pressure, heart disease, and strokes. Potassium lowers blood pressure and may help prevent heart disease and strokes in the general population, but has not been well-studied in…
- Trial name
- CKD-K (NCT00949585)
- Testing
- Dietary intake of potassium
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Acute Kidney Injuries
the Percent of AKI Occurred in Patient With Comorbidities Undergoing Colonoscopy
observation the percent AKI in patient with comorbidities undergoing colonoscopy
- Trial name
- NCT06743815
- Volunteers
- 113 people
- Sponsor
- Assiut University
Diabetes Mellitus and Heart Failure
A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure
This was a dose-finding study to evaluate the efficacy, safety and tolerability of 3 different doses of LIK066 compared to placebo or empagliflozin in T2DM patients with heart failure
- Trial name
- NCT03152552
- Testing
- LIK066, Empagliflozin
- Where
- 106 sites in United States, Argentina and 22 more
- Volunteers
- 125 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Failure, Chronic, Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Renal Diseased Patients
The purpose of this study is to determine whether sugammadex reverses a profound neuromuscular blockade induced by rocuronium in patients with end-stage renal disease just as effectively and safely as it does in patients with…
- Trial name
- NCT01785758
- Testing
- Sugammadex (4 mg/Kg)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
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