Clinical trials: Renal Impairment
Diabetes Mellitus Type 2
A Study of RO4998452 in Type 2 Diabetes Patients With Varying Degrees of Renal Impairment
This 4 arm study will investigate the pharmacodynamics and pharmacokinetics of RO4998452 in type 2 diabetes patients with varying degrees of renal impairment.
- Trial name
- NCT00933972
- Testing
- RO4998452
- Where
- 2 sites in United States, Russia
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Neoplasm Malignant
Pharmacokinetics and Safety Study of Cabazitaxel in Cancer Patients With Renal Impairment
Primary Objective: To assess potential impact of moderate and severe renal impairment on the pharmacokinetics of cabazitaxel Secondary Objective: To assess the safety of cabazitaxel in patients with various degrees of renal…
- Trial name
- NCT01527929
- Testing
- Cabazitaxel XRP6258
- Where
- 7 sites in Belgium, Italy and 3 more
- Volunteers
- 25 people
- Sponsor
- Sanofi
Cardiovascular Disease
A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants
The purpose of this study is to measure how much of the study drug, evacetrapib, enters the blood stream and how long it takes the body to dispose of the study drug when given to participants with severe renal (kidney) impairment…
- Trial name
- NCT01825889
- Testing
- Evacetrapib
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Cancer, Chronic Renal Failure
Identification of Palliative Care Needs and Prognostic Factors of Survival in Tailoring Appropriate Interventions in Advanced Oncological, Renal and Pulmonary Diseases
This is a prospective observational study done on 3 patient populations (cancer, chronic pulmonary and renal disease). All patients will be treated and monitored according to the local clinical practice.
- Conditions
- Cancer, Chronic Renal Failure, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT06909968
- Testing
- palliative care
- Where
- 5 sites in Italy
- Volunteers
- 178 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Acute Kidney Injury, Sepsis
Doppler Ultrasound for Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients
Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent Acute Kidney Injury (AKI) using the color Doppler Ultrasound derived Renal Resistive Index (RI) and…
- Conditions
- Acute Kidney Injury, Sepsis, Renal Resistive Index
- Trial name
- NCT03597074
- Testing
- color Doppler Ultrasound derived RI and semi-quantitative evaluation of intra-renal vascularization
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Aristotle University Of Thessaloniki
Type 2 Diabetes Mellitus, Chronic Kidney Disease
A Study of Renal Autologous Cell Therapy (REACT) in Type 2 Diabetics With Chronic Kidney Disease
To assess the safety and efficacy of up to two REACT injections given 6 months (+4 weeks) apart and delivered into the biopsied kidney using a percutaneous approach in participants with Type 2 Diabetes Mellitus (T2DM) and Chronic…
- Trial name
- NCT02836574
- Testing
- Renal Autologous Cell Therapy (REACT), Renal Biopsy
- Where
- 16 sites in United States
- Volunteers
- 83 people
- Sponsor
- Prokidney
Iron Deficiency Anaemia, Iron Deficiency Anemia
Iron Isomaltoside/Ferric Derisomaltose vs Iron Sucrose for Treatment of Iron Deficiency Anemia in Non-Dialysis-Dependent Chronic Kidney Disease
Evaluation of safety and efficacy of iron isomaltoside/ferric derisomaltose compared with iron sucrose, in subjects with both non-dialysis-dependent chronic kidney disease (NDD-CKD) and iron deficiency anaemia (IDA).
- Conditions
- Iron Deficiency Anaemia, Iron Deficiency Anemia, Chronic Kidney Disease
- Trial name
- NCT02940860
- Testing
- Iron isomaltoside/ferric derisomaltose, Iron sucrose
- Where
- 141 sites in United States
- Volunteers
- 1,538 people
- Sponsor
- Pharmacosmos A/S
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Healthy, Myocardial Fibrosis
Molecular MRI of the Fibrotic Heart
This study is a feasibility study to validate magnetizatin transfer (MT)-weighted balanced steady state free precession (bSSFP) cine cardiac magnetic resonance (CMR) against current clinical gold standard diagnostics, and to…
- Conditions
- Healthy, Myocardial Fibrosis, Chronic Kidney Disease
- Trial name
- NCT02012725
- Testing
- Arm 1 MRI with gadolinium
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Moriel Vandsburger
Calciphylaxis
SEAPORT 1: Study of INZ-701 in Adults With Hemodialysis-Dependent End-Stage Kidney Disease
This Phase 1, open-label, multicenter study evaluated the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of INZ-701 in adults with hemodialysis-dependent end-stage kidney disease (ESKD) and low plasma inorganic…
- Trial name
- SEAPORT 1 (NCT06283589)
- Testing
- INZ-701
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Inozyme Pharma
Acute Kidney Injury, Acute Kidney Injury KDIGO 2
Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney Injury
Acute Kidney Injury is a serious, common illness that is associated with poor health outcomes. Prolonged hospitalisation is a common experience of patients admitted with this illness.
- Conditions
- Acute Kidney Injury, Acute Kidney Injury KDIGO 2, Acute Kidney Injury KDIGO 3, Muscle Wasting
- Trial name
- NMES-AKI (NCT07915713)
- Testing
- Neuromuscular electrical stimulation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Hemodialysis, End Stage Renal Disease (ESRD)
Kinesiophobia, Pain, Balance, Quality of Life and Mental Status in Hemodialysis Patients
The aim of our study was to investigate the relationship between kinesiophobia and pain, balance, physical performance, quality of life and mental status in patients receiving hemodialysis.
- Trial name
- NCT06696274
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Chronic Kidney Disease
FINE-START: Efficacy and Safety of Finerenone in Patients With Chronic Kidney Disease Not Using Renin-angiotensin-system Inhibitors
Study to demonstrate efficacy of finerenone when compared to placebo in reducing albuminuria in participants with chronic kidney disease (CKD) not using renin-angiotensin-system (RAS) inhibitors.
- Trial name
- FINE-START (NCT07181135)
- Testing
- Finerenone (BAY 94-8862)
- Where
- 8 sites in Spain
- Volunteers
- 180 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Disease
Vascular Reactivity in Chronic Kidney Disease (CKD) Patients Receiving Paricalcitol Versus Placebo
This research is studying how Vitamin D may affect blood vessels reaction to stress and blood levels of substances that may increase blockages in the blood vessels in chronic kidney disease (CKD) patients.
- Trial name
- NCT00915876
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Amy Barton Pai
Acute Renal Failure, Iatrogenic Effect
Detection of Acute Renal Failure Using Hospital Coding Data
AKI is a rapid and usually reversible impairment of kidney function that is life-threatening in the short term well described by the "Kidney Disease: Improving Global Outcomes - KDIGO" classification of 2012.
- Conditions
- Acute Renal Failure, Iatrogenic Effect, Uremic Toxin
- Trial name
- IRA-PMSI (NCT04923750)
- Where
- France
- Volunteers
- 498 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease, Renal Dialysis
A Phase 3 Study in Patients With Chronic Kidney Disease and Hyperphosphatemia on Peritoneal Dialysis
This is a multi-center, open-labeled, non-comparative study to examine the safety and efficacy of ASP1585 in chronic kidney disease and hyperphosphatemia patients on peritoneal dialysis.
- Conditions
- Chronic Kidney Disease, Renal Dialysis, Renal Insufficiency
- Trial name
- NCT01017276
- Testing
- ASP1585
- Where
- 3 sites in Japan
- Volunteers
- 35 people
- Sponsor
- Astellas Pharma Inc
Renal Insufficiency, Healthy
A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 1467335 is Processed in the Body
The primary objective of the current study is to investigate the influence of moderate renal impairment on the pharmacokinetics of multiple doses in comparison to a matched control group with normal renal function.
- Trial name
- NCT03302091
- Testing
- BI 1467335
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
IgA Nephropathy, ESRD
TESTING -ON Post-Trial ObservatioNal Cohort Study
The primary aim of this study is to extend follow up of TESTING study participants and to assess the long-term effects of a 6-9-month course of oral methylprednisolone on End Stage Kidney Disease (ESKD), according to dose…
- Conditions
- IgA Nephropathy, ESRD, Glomerulonephritis, Kidney Diseases
- Trial name
- TESTING-ON (NCT05434325)
- Where
- 59 sites in Australia, Canada and 4 more
- Volunteers
- 211 people
- Sponsor
- The George Institute
Renal Failure
Restenosis Following Paclitaxel Eluting Balloon Angioplasty of Hemodialysis Access Stenosis
Introduction: Narrowing of the draining vein occurs in >50% of hemodialysis fistula and left untreated will lead to loss of access. The narrowing is due to excessive growth of tissue in the vessel wall (intimal hyperplasia).
- Trial name
- NCT01001676
- Testing
- Percutaneous Transluminal Angioplasty (PTA), Paclitaxel Eluting Balloon Angioplasty
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
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