Clinical trials: Renal Impairment
Chronic Kidney Diseases
Sleep-time Blood Pressure and Risk of CKD Progression
The SLEEP-BP-CKD Study has been designed to specifically test the following primary hypotheses: (i) Specific ABPM-derived parameters, in particular the asleep SBP mean and/or the sleep-time relative SBP decline, are significant…
- Trial name
- SLEEP-BP-CKD (NCT05189418)
- Testing
- Ambulatory blood pressure monitoring (ABPM), Home blood pressure monitoring (HBPM)
- Where
- 10 sites in Spain
- Volunteers
- 210 people
- Sponsor
- University of Vigo
Renal Disease, End-Stage, Renal Insufficiency, Chronic
Bosutinib In Subjects With Renal Impairment
This is a two-staged study of a single dose of 200 mg of bosutinib given to subjects with renal impairment and matching healthy volunteers.
- Conditions
- Renal Disease, End-Stage, Renal Insufficiency, Chronic, Renal Insufficiency, Acute
- Trial name
- NCT01233882
- Testing
- Bosutinib
- Where
- 5 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pfizer
End-stage Renal Disease, Kidney Transplantation
Evaluation of Desensitization Protocols in HLA-incompatible Kidney-transplant Candidates
Kidney transplantation is the best renal-replacement in the setting of end-stage renal disease. However, some transplant candidates have developed anti-HLA alloantibodies (human leukocyte antigen).
- Conditions
- End-stage Renal Disease, Kidney Transplantation, Hla-incompatible Kidney Transplant Candidates
- Trial name
- NCT03507348
- Testing
- visits of tocilizumab injection (every 4 weeks, up to 5 visits), Rituximab 375 mg/m2 at Day-30, Rituximab 375 mg/m2 at Day-15 (only for donors living)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 With Proteinuria
Decentralized N=1 Study: A Feasible Approach to Evaluate Individual Therapy Response to Dapagliflozin.
Randomized placebo-controlled double-blind cross-over N=1 trial in adult male and female patients with UACR >20 mg/g (2.26 mg/mmol) with type 2 diabetes treated in primary or secondary healthcare.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 With Proteinuria, Diabetes Mellitus, Diabetes
- Trial name
- @HOME (NCT06374043)
- Testing
- Dapagliflozin 10mg Tab, Withings BPM Connect, Withings Body+
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Diseases
Dapagliflozin in Non-diabetic Stage IV CKD
This is a phase 2b, prospective, randomized, cross-over, double-blind, placebo-controlled trial primarily aimed at assessing whether the SGLT2 inhibitor dapagliflozin ameliorates hyperfiltration and reduces proteinuria as…
- Trial name
- ADAPT (NCT04794517)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Nephrectomy, Acute Kidney Injury
Effect of Fluid Regimen on Acute Kidney Injury
Postoperative acute kidney injury (AKI) is an important surgical complication that increases hospital stay and mortality when it occurs after kidney surgery.
- Conditions
- Nephrectomy, Acute Kidney Injury, Fluid Therapy
- Trial name
- NCT06256120
- Testing
- Restrictive, Liberal
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muğla Sıtkı Koçman University
Chronic Kidney Disease, Dialysis
Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia
The primary objective of this study is to demonstrate the long-term safety and tolerability of MCI-196 in the subjects with stage V chronic kidney disease on dialysis with hyperphosphatemia.
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia
- Trial name
- NCT00772382
- Testing
- MCI-196
- Where
- 21 sites in United States, Canada
- Volunteers
- 116 people
- Sponsor
- Tanabe Pharma Corporation
Acute Kidney Injury, Exercise-associated Hyponatremia
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
The specific aim of this study is to evaluate the safety of non-steroidal anti-inflammatory drugs (NSAIDs) and their impact on renal function and/or contribution to exercise-associated hyponatremia (EAH) during an ultramarathon…
- Conditions
- Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion
- Trial name
- NAKED (NCT02272725)
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
Multiple Myeloma
A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency
This research study is studying a possible therapy as a possible treatment for the consequences of Multiple Myeloma with renal insufficiency.
- Trial name
- NCT02833610
- Testing
- Denosumab Q4W
- Where
- 7 sites in United States
- Volunteers
- 55 people
- Sponsor
- Massachusetts General Hospital
Chronic Renal Insufficiency
Very Low Protein Diet and Renal Death in Chronic Kidney Disease (CKD)-ERIKA Study
The purpose of this study is to determine whether the use of a very low protein diet is effective in delaying the start of chronic dialysis treatment in patients affected by chronic kidney disease (CKD).
- Trial name
- NCT00323713
- Testing
- Very low protein diet, Low protein diet
- Where
- 17 sites in Italy
- Volunteers
- 360 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Chronic Kidney Disease, Stage 5, Secondary Hyperparathyroidism
A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease
The purpose of this study is to evaluate the effects of Zemplar® Injection and Hectorol® Injection on intestinal calcium absorption in Chronic Kidney Disease Stage 5 subjects on hemodialysis.
- Trial name
- NCT00257920
- Testing
- Zemplar® injection, Hectorol® injection
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Abbott
Renal Insufficiency, Chronic
Chronic Kidney Disease - Renal Epidemiology and Information Network
Preserving kidney function and improving the transition from CKD to End stage renal disease (ESRD) is a research and healthcare challenge.
- Trial name
- CKD-REIN (NCT03381950)
- Where
- France
- Volunteers
- 3,033 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Kidney Disease, End-Stage Renal Disease
House Calls and Peer Mentorship
Live donor kidney transplantation (LDKT) offers the most optimal survival and quality of life benefit for those with late-stage chronic kidney disease.
- Trial name
- HC+PM (NCT03354910)
- Testing
- House Call, Peer Mentorship
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Beth Israel Deaconess Medical Center
Renal Impairment
A Study to Evaluate the Pharmacokinetics of HSK21542 in Subjects With Renal Impairment
This is an open-label, single-dose study to evaluate the pharmacokinetics and safety of HSK21542 in subjects with mild, moderate and severe renal impairment compared to the matched control subjects with normal renal function.
- Trial name
- NCT05947097
- Testing
- HSK21542 Injection
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Anemia in Incident Dialysis Patients
Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
The purpose of this study is to determine whether roxadustat is safe and effective in the treatment of anemia in participants who have just begun dialysis treatment for ESRD.
- Trial name
- Himalayas (NCT02052310)
- Testing
- Roxadustat, Epoetin Alfa
- Where
- 113 sites in United States, Argentina and 13 more
- Volunteers
- 1,043 people
- Sponsor
- Kyntra Bio
Kidney Disease, Chronic
An Observational, Prospective, Safety Study of Mircera (Monopegylated Epoetin Beta) in Clinical Practice
This national study was a post-marketing surveillance study conducted in Korea from 29 August 2008 to 28 August 2012 to meet local regulatory requirements for Mircera (monopegylated-epoetin beta).
- Trial name
- NCT02263833
- Testing
- Mircera
- Where
- South Korea
- Volunteers
- 748 people
- Sponsor
- Hoffmann-La Roche
Hyperthermia, Kidney Injury, Acute
Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain
Prolonged, high intensity work in a hot environment results in significant strain on the body, known as heat strain. Heat strain in hot occupational settings such as agriculture, fire suppression, and military work can lead to…
- Trial name
- NCT05710978
- Testing
- Work Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
End Stage Renal Disease, Restless Legs Syndrome
Biotin Deficiency and Restless Legs Syndrome
Restless Leg Syndrome (RLS) is a common neuropathic disorder in patients with end stage renal disease (ESRD). Study Design: Because micronutrient depletion has been associated with RLS in ESRD and because the vitamin biotin is…
- Trial name
- NCT02011191
- Testing
- Biotin Supplementation, Sugar Pill
- Volunteers
- 49 people
- Sponsor
- Heidi Moretti, MS, RD
Acute Kidney Injury
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT).
- Trial name
- OMAKI (NCT00675818)
- Testing
- Continuous venvenous hemofiltration (CVVH), Continuous venovenous hemodialysis (CVVHD)
- Where
- 5 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Chronic Kidney Disease
Efficacy of the 6-point Diet
The dietary restriction of proteins and sodium is a cornerstone in the treatment of chronic kidney disease (CKD) and of its metabolic consequences. Dietary adjustments in CKD are complex and the patients' compliance is very low.
- Trial name
- PIS (NCT01865526)
- Testing
- Six point diet, Low protein diet
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federico II University
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