Clinical trials: Renal Injury, Acute
Acute Kidney Injury
The Effect of the Hydroxyethyl Starch on Kidney Injury in Pediatric Cardiac Surgery
The investigator will evaluate the influence of colloid administration on postoperative acute kidney injury in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass.
- Trial name
- NCT02599155
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
AKI
Protection From Acute Kidney Injury (AKI) With Basis™ Treatment
This study is a single-center, prospective, randomized, double-blinded, placebo-controlled phase II clinical trial to evaluate the efficacy of "NAD+ supplementation" with Basis™ (Nicotinamide Riboside and Pterostilbene) in…
- Trial name
- NCT04342975
- Testing
- Nicotinamide Riboside + Pterostilbene
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Severe Sepsis, Septic Shock
Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury
Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy.
- Conditions
- Severe Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT00837057
- Testing
- crrt
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Acute Kidney Injury, Intra-dialytic Hypotension
Low Dialysate Temperature During SLED
Objectives: This study is evaluating the hemodynamic effects of lowering the dialysate temperature in acute kidney injury (AKI) patients submitted to sustained low efficiency dialysis (SLED) in a single large center.
- Trial name
- NCT03397992
- Testing
- Changing dialysate temperature
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
Long-term Renal Dysfunction
Comparison of the Effects of Open and Endovascular Aortic Aneurysm Repair on Long-term Renal Function
Compare the renal complication of endovascular and open repair of acute aortic dissection by including patient treated at NTUH in 2010~2013.
- Trial name
- NCT02220283
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Continuous Venovenous Hemofiltration
Bionenergetic Balance During CVVH
The bioenergetic balance is the sum of energy exchanged during CRRT and is mostly defined by citrate glucose and lactate. When CRRT was performed with the older dialysis fluids, glucose and lactate could be an important source of…
- Conditions
- Acute Kidney Injury, Continuous Venovenous Hemofiltration, Energy Metabolism, Resting Energy Expenditure
- Trial name
- BALANCE (NCT06483542)
- Testing
- bioenergetic balance
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Acute Kidney Injury
Evaluation of a Novel Method of Contrast Volume Quantification - AVERT PLUS 2.0
Purpose: To evaluate the accuracy of the AVERT PLUS to monitor contrast volume used during angiographic procedures. This will be a first in man prospective observational study of the accuracy of this system to quantify contrast…
- Trial name
- NCT02578173
- Testing
- AVERT PLUS
- Volunteers
- 20 people
- Sponsor
- Anand Prasad
Acute Renal Failure
Vasodilators and Anti-Oxidant Therapy in Early ATN
Patients developing kidney failure after open heart surgery experience an abrupt decrease in blood flow to the kidney. The investigators hypothesize that administration of fenoldopam mesylate (a drug that increases blood flow to…
- Trial name
- NCT00286403
- Testing
- Fenoldopam Mesylate and/or MESNA
- Where
- 2 sites in United States
- Sponsor
- Southeast Renal Research Institute
Acute Kidney Injury
Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery
This is a prospective randomized clinical trial designed to determine the effect of intraoperative dexmedetomidine administration on renal function after coronary artery bypass graft surgery.
- Trial name
- NCT06378827
- Testing
- Dexmedetomidine
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- University of Novi Sad
Hypotension, Acute Renal Failure
N-acetylcysteine Plus Deferoxamine for Patients With Hypotension
Oxidative stress is associated with kidney damage in several different situations, including hypotension. In animal models it has been shown that the combination of n-acetylcysteine plus deferoxamine is superior to its isolate…
- Trial name
- NCT00870883
- Testing
- N-acetylcysteine and deferoxamine
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Sepsis, Septic Shock
Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Injury
The primary objective of this study is to investigate whether using SGLT2i may be associated with decreased incidence of sepsis-induced AKI or not.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06902493
- Testing
- No intervention
- Where
- Saudi Arabia
- Volunteers
- 664 people
- Sponsor
- University of Jazan
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Acute Kidney Injury
Acute Kidney Injury After Cardiac Arrest
The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.
- Trial name
- NCT06544538
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Acute Kidney Disease
Demethylating Agent Azacitidine on Prevention of Acute Kidney Injury-chronic Kidney Disease Continuum
Acute kidney injury (AKI) is increasing worldwide in recent years and is a major risk factor of chronic kidney disease (CKD). AKI, acute kidney disease (AKD) and CKD form a continuum whereby initial kidney injury leads to ongoing…
- Trial name
- NCT05325099
- Testing
- Azacitidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Multiple Myeloma, Acute Renal Failure
Trial of Plasma Exchange for Acute Renal Failure at the Onset of Myeloma
Background:Plasma exchange has been suggested to be of theoretical benefit in the treatment of acute renal failure at the onset of multiple myeloma. Two small-randomized trials provide conflicting evidence.
- Trial name
- NCT00120263
- Testing
- Plasma Exchange
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- London Health Sciences Centre
Renal Insufficiency, Acute, Renal Insufficiency, Chronic
Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency
This is a Phase 1, open-label, single-dose study of the safety, tolerability, and pharmacokinetics of Minocin® (minocycline) for injection in subjects with renal insufficiency.
- Conditions
- Renal Insufficiency, Acute, Renal Insufficiency, Chronic, Healthy Subjects
- Trial name
- NCT02808052
- Testing
- Minocin (minocycline) for Injection
- Where
- Germany
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Acute Kidney Injury
Use of Care Bundle in Acute Kidney Injury
This study is a service evaluation to assess the impact of compliance of Acute Kidney Injury care bundle (AKI-CB) on clinical and renal outcomes.
- Trial name
- NCT02534584
- Where
- United Kingdom
- Volunteers
- 944 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Acute Kidney Injury
Predictors of Acute Kidney Injury in Critically Ill Children Admitted to PICU.
Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year.
- Trial name
- NCT06328478
- Testing
- Observational prospective study.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury
Cystatin c: a Biomarker of AKI in Aneurysmal Subarachnoid Haemorrhage Patients
The goal of this observational study is to assess cystatin c as a predictive biomarker of early acute kidney injury in aneurysmal subarachnoid hemorrhage patients.
- Trial name
- NCT06635408
- Testing
- cystatin c
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Cardiac Surgery Associated - Acute Kidney Injury, AKI - Acute Kidney Injury
Safety & Efficacy of RenalGuard® Therapy in the Prevention of Cardiac Surgery Associated Acute Kidney Injury
The goal of this clinical trial is to assess the effect of RenalGuard Therapy in reducing the rates of Acute Kidney Injury (AKI) within 72 hours after cardiac surgery in patients at risk of developing Cardiac Surgery Associated…
- Trial name
- SAFEGUARD (NCT07123935)
- Testing
- RenalGuard® Therapy, Standard of Care (SOC)
- Where
- 2 sites in Malaysia
- Volunteers
- 300 people
- Sponsor
- CardioRenal Systems, Inc.
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