Clinical trials: Renal Injury, Acute
Hip Fractures, Hypotension on Induction
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
Background During anaesthesia for repair of a broken hip, many patients experience low blood pressure. There have been many studies showing that patients who experience low blood pressure during anaesthesia are at increased risk…
- Conditions
- Hip Fractures, Hypotension on Induction, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- iSTABILISE (NCT04051073)
- Testing
- Continuous non-invasive blood pressure monitoring
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Pre-Eclampsia
Restrictive Fluid Therapy in Severe Preeclampsia
Introduction: Pre-eclampsia is a multifactorial syndrome which occurs in hypertension and proteinuria in pregnant women over 20 weeks gestation.
- Trial name
- NCT02214186
- Testing
- Restrictive Fluid Therapy
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
In Acute Kidney Injury
The Relationship Between Serum and Urinary Angiotensinogen Levels and Long-Term Renal Prognosis in Acute Renal Injury
This study aims to retrospectively examine long-term (at the end of the 3rd year) renal function in the thesis study titled "Investigation of serum and urine angiotensinogen levels as a prognostic indicator of renal function in…
- Trial name
- Renal Injury (NCT07512661)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Covid19, Stage 1 Acute Kidney Injury
Phase 2a MIB-626 vs. Placebo COVID-19
The proposed phase 2a trial will determine whether MIB-626 treatment in adults with COVID-19 infection and stage 1 acute kidney injury is more efficacious than placebo in preventing worsening of kidney function, as assessed by…
- Trial name
- NCT05038488
- Testing
- MIB-626, Home Treatment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Metro International Biotech, LLC
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Non ST Segment Elevation Acute Coronary Syndrome
COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
Since colchicine is known to have anti-inflammatory effects and inflammation is an early component of acute coronary syndrome (ACS), this study aims to evaluate the acute effects of low-dose colchicine, in addition to…
- Trial name
- COLOR-ACS (NCT05250596)
- Testing
- Colchicine, Atorvastatin
- Where
- 3 sites in Italy
- Volunteers
- 182 people
- Sponsor
- Azienda USL Toscana Centro
Acute Kidney Injury
Transcriptional and Proteomic Analysis of Acute Kidney Injury
Acute kidney injury is associated with worsened outcome for critically ill patients. Sepsis-associated and non-septic cardiothoracic surgery associated AKI have been reported, nonetheless, precise pathomechanistic differences as…
- Trial name
- TPA-AKI (NCT06064305)
- Testing
- No study-specific interventions
- Volunteers
- 60 people
- Sponsor
- University Hospital Muenster
Acute Kidney Injury, Ventricular Dysfunction
Acute Kidney Injury as a Risk Factor for Myocardial Injury and Ventricular Dysfunction
Acute kidney injury (AKI) is classically described as an abrupt or rapidly reversible reduction in the excretion of nitrogenous waste products, including urea, nitrogen and creatinine.
- Conditions
- Acute Kidney Injury, Ventricular Dysfunction, Myocardium; Injury
- Trial name
- NCT04768751
- Testing
- kidney assessment
- Where
- Egypt
- Volunteers
- 520 people
- Sponsor
- South Egypt Cancer Institute
Acute Kidney Failure
Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury
Acute kidney injury (AKI) is a major organ failure in septic shock. Current medical tests (serum creatinine and urea) cannot identify AKI until approximately 48 hours after it occurs.
- Trial name
- NESAKI (NCT01122225)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Renal Perfusion, Minimally Invasive Surgical Procedures
Assessment of Renal Perfusion Using Ultrasound and Near-Infrared Spectroscopy in Patients Undergoing Minimally Invasive Abdominal Surgery
This prospective observational study aims to evaluate renal perfusion in adult patients undergoing elective minimally invasive abdominal surgery.
- Conditions
- Renal Perfusion, Minimally Invasive Surgical Procedures, Acute Kidney Injury
- Trial name
- RRI-NIRS (NCT07635160)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul University - Cerrahpasa
Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome
Development and Validation of a Risk Prediction Model for Cardiac Surgery-associated Acute Kidney Injury Based on the Gut-Kidney Axis, Incorporating Gut Microbiota and Their Metabolites
This is a single-center prospective observational cohort study enrolling adult patients scheduled for cardiac surgery. Multi-timepoint clinical indicators, stool samples for gut microbiota and metabolomics profiling and artery…
- Conditions
- Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome, Metabolome, Risk Assessment
- Trial name
- NCT07738796
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Peking Union Medical College Hospital
Acute Kidney Injury
Intraabdominal Pressure Monitoring Urinary Catheter and Kidney Perfusion Pressure
The goal of this clinical trial is to determine whether monitoring intra-abdominal pressure (IAP) and adjusting blood pressure accordingly to maintain optimal renal perfusion pressure can reduce the risk of acute kidney injury…
- Trial name
- NCT06989762
- Testing
- Conventional Foley Catheter(Medline), Accuryn Foley Catheter
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Dang Tan Phat
Coronary Artery Bypass
Study of Roxadustat for Reducing the Incidence of Acute Kidney Injury After Coronary Artery Bypass Grafting
Acute kidney injury is a frequent complication after coronary artery bypass grafting (CABG). Roxadustat is a prolyl hydroxylase inhibitor (PHI) which can stabilize hypoxia-inducible factor (HIF) and improve the hypoxic tolerance…
- Trial name
- NCT05010460
- Testing
- Roxadustat
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Smoke Inhalation Patients
Impact of Hydroxocobalamine on Outcome of Smoke Inhalation Injury Admitted to the ICU
In Europe, hydroxocobalamin (cyanokit) has been used for suspicion of cyanide intoxication associated with the inhalation of fire smoke (1). However, the impact of hydroxocobalamin on outcome has never been thoroughly evaluated.
- Trial name
- COB-AKI (NCT03558646)
- Testing
- There is no intervention planned (observational)
- Where
- France
- Volunteers
- 739 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT)
Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)
The purpose of this research is to determine if an investigational new drug solution called Prismocitrate 18 lengthens extracorporeal circuit life in patients treated with continuous renal replacement therapy (CRRT).
- Conditions
- Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury
- Trial name
- NCT02860130
- Testing
- Prismocitrate 18, No Anticoagulation
- Where
- 12 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Vantive Health LLC
Kidney Injury, Acute
Perioperative Use of NAC to Prevent AKI in Patients With Pre-existing Moderate Renal Insufficiency Following Cardiac Surgery
Acute kidney injury (AKI) or renal impairment is an established complication of cardiac surgery occurring with an incidence up to 30%, To date, no agent has conferred renal protection.
- Trial name
- NCT05555511
- Testing
- Control Group
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
AKI - Acute Kidney Injury
The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients
With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU).
- Trial name
- NCT07624721
- Where
- Belgium
- Volunteers
- 1,416 people
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury
Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients
Acute kidney injury (AKI) is a frequent complication in critically ill patients admitted to intensive care unit (ICU) and it is associated with increased morbimortality.
- Trial name
- GDT-AKIN (NCT02414906)
- Testing
- Goal-directed therapy
- Volunteers
- 99 people
- Sponsor
- Barretos Cancer Hospital
Acute Kidney Injury
Acute Kidney Injury - Biomarkers in Major Abdominal Surgery
To validate Urinary Biomarkers for the prediction of AKI in major abdominal surgery patients
- Trial name
- AKI-BioMAS (NCT04582747)
- Testing
- Urinary Biomarkers (NGAL, DKK-3, IGFBP-7/TIMP-2, KIM-1)
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
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