Clinical trials: Renal Injury, Acute
Acute Kidney Injury
Acute Kidney Attack in Severe Traumatized Patients
Acute Kidney Injury (AKI) is a common complication of severe traumatized patients. The diagnosis is often delayed. The Nephrocheck® test allows an earlier assessment of renal stress.
- Trial name
- NEPHROTRAUMA (NCT03877978)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Hospices Civils de Lyon
Kidney Transplantation, Acute Rejection of Renal Transplant
Donor-derived Cell-free DNA in Kidney Transplant Recipients
Donor-derived cell-free DNA (dd-cfDNA) is a promising non-invasive biomarker of kidney allograft rejection. In this prospective, single center, observational monitoring study, we aim to evaluate a role of dd-cfDNA in predicting…
- Trial name
- DEFILE (NCT06476717)
- Testing
- Biopsy, Blood Biomarkers - cfDNA, Antirejection therapy
- Where
- Czechia
- Volunteers
- 143 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute Kidney Injury
Long-term Survival and Renal Outcomes in Critically Ill Patients After Acute Kidney Injury: Swedish Multi-centre Cohort Study
The study evaluates how outcome varies among critically ill patients with and without acute kidney injury. Data from the Swedish Intensive care register and other Swedish national registers is used to compare how survival and…
- Trial name
- NCT02424747
- Testing
- Acute Kidney Injury
- Volunteers
- 103,000 people
- Sponsor
- Karolinska Institutet
AKI - Acute Kidney Injury
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Contrast-associated acute kidney injury (CA-AKI) is a common complication of procedures with intravascular contrast. Generally, CA-AKI is defined as serum creatinine (Scr) ≥ 25 to 50% or Scr rise around 0.3 to 0.5 mg/dl.
- Trial name
- NCT05540184
- Testing
- Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Acute Kidney Injury
Dcr3 Levels in Blood and Urine on Renal and Patient Prognosis in Patients With Acute Kidney Injury
Kidney diseases represent a global public health problem due to the aging of the population, the increasing prevalence of diabetes, hypertension, obesity and immune disorders.
- Trial name
- NCT05735093
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kırıkkale University
Acute Kidney Injury
Acute Kidney Injury in Neonatal ICU in Assuit University
The kidneys of neonates are particularly susceptible to hypoperfusion because of the physiologic characteristics of neonatal kidneys, including high renal vascular resistance, high plasma renin activity, low glomerular filtration…
- Trial name
- NCT07083284
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cardiac Surgery, Coronary Artery Bypass Grafting
Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery
The purpose of the present research study is to investigate the pharmacokinetics, as well as safety, tolerability and pharmacodynamics of different ascending dosing regimens of AP214 in patients undergoing cardiac surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Valve Surgery, Aortic Root or Ascending Aortic Aneurysm Repair Surgery
- Trial name
- NCT00903604
- Testing
- AP214
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Action Pharma A/S
Transplantation of Kidney, Expanded Criteria Donor
Efficacy and Safety of Everolimus in de Novo Kidney Transplant Recipients of ECD or AKI Donors
Single center, open-label randomized-control trial Population: de novo 48 kidney transplant recipients (age 18-75 years) from ECD/AKI donors Compare: everolimus with low dose CNI and prednisolone versus standard immunosuppressive…
- Conditions
- Transplantation of Kidney, Expanded Criteria Donor, ECD
- Trial name
- NCT02314312
- Testing
- Everolimus + low dose cyclosporin A + prednisolone, Standard immunosupressive regimen
- Volunteers
- 48 people
- Sponsor
- Mahidol University
Acute Kidney Injury, Renal Transplantation
Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients
Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant.
- Trial name
- DART-REIN (NCT06026592)
- Testing
- determination of circulating biomarkers of renal origin circulating biomarkers of renal origin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Oral Salt and Water to Prevent Contrast Nephropathy
The purpose of this pilot trial is to determine the safety and feasibility of using oral salt and water loading compared to intravenous saline for the prevention of contrast-induced acute kidney injury in patients with chronic…
- Trial name
- NCT02084771
- Testing
- Intravenous Saline, Oral Salt and Water
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Critical Illness, Hyperglycemia
Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill Patients
Critically ill patients admitted to intensive care units (ICUs) frequently develop elevated blood sugar levels (hyperglycemia) as a result of acute illness-related stress, even if they do not have diabetes.
- Conditions
- Critical Illness, Hyperglycemia, Acute Kidney Injury, Multiple Organ Failure
- Trial name
- NCT07853911
- Volunteers
- 230 people
- Sponsor
- Assiut University
Laparoscopic Colorectal Surgery, Acute Kidney Injury
The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients
This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in…
- Trial name
- NCT03408834
- Testing
- pulse variability index
- Volunteers
- 29 people
- Sponsor
- Ankara University
Acute Coronary Syndrome, Contrast-Induced Acute Kidney Injury
Predictors of Contrast-induced Acute Renal Injury in Patients With Acute Coronary Syndrome
This observational study aims to identify predictors of contrast-induced acute kidney injury (CI-AKI) in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
- Trial name
- PC-AKI-ACS (NCT07294911)
- Testing
- Observational data collection
- Where
- Kazakhstan
- Volunteers
- 88 people
- Sponsor
- Karaganda Medical University
Acute Kidney Failure
Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
Deterioration of kidney renal function occurs in a minority of people due to contrast-required procedures. The purpose of this study is to compare two different interventions to reduce the risk of kidney injury after contrast…
- Trial name
- PROMEC (NCT00472563)
- Testing
- Bicarbinate 150 mEq/L
- Where
- Colombia
- Volunteers
- 212 people
- Sponsor
- Universidad de Antioquia
Aneurysm Aortic
Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Juxtarenal Abdominal Aortic Aneurysm
Juxta-renal abdominal aortic aneurysms (AAA) are challenging to treat with standard endovascular techniques (EVAR) due to their proximity to the renal arteries.
- Trial name
- EPAKI (NCT07441564)
- Testing
- patients with aortic clamping with preconditioning, patients with aortic clamping without preconditioning
- Where
- 7 sites in France
- Volunteers
- 206 people
- Sponsor
- University Hospital, Rouen
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Oxidative Stress and Circulating Nuclear DNA (cfDNA) in Acute Kidney Injury and Continuous Renal Replacement Therapies.
Acute kidney injury (AKI) is the inability of the kidneys to perform their functions of purifying and cleaning the blood. It is a frequent complication in hospitalized patients, especially in those admitted to the ICUs.
- Trial name
- NCT06646328
- Testing
- Central venous access, Pump-assisted circuit, Heparin sodium
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fernando Sanchez
Hypercholesterolemia
High Potency Statins and Acute Kidney Injury
Statins are a class of cholesterol lowering medications that are prescribed for the prevention and treatment of cardiovascular disease.
- Trial name
- NCT02518516
- Testing
- Rosuvastatin (≥10 mg), Atorvastatin (≥20 mg), Simvastatin (≥40 mg)
- Where
- Canada
- Volunteers
- 2,067,639 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Renal Replacement Therapy
Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy
Regional citrate anticoagulation (RCA) is the recommended method for anticoagulation in continuous renal replacement therapy (CRRT). However, the optimal post-filter ionized calcium (iCa) target level remains unclear.
- Trial name
- Ca-CIBLE (NCT05814341)
- Testing
- Citrate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabete Mellitus
Risk Factors for Acute Kidney Injury in Diabetic Patients
incidence of AKI in diabetic patients seems to be influenced by multiple risk Factors like severe infections, elderly, poor diabetic control, previous AKI, chronic kidney disease and drugs like SGLT2-I increase risk of AKI in…
- Trial name
- NCT05147818
- Testing
- CBC ,renal function tests , fundus Examination
- Volunteers
- 400 people
- Sponsor
- Assiut University
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