Clinical trials: Renal Injury, Acute
Contrast-induced Nephropathy, Acute Kidney Injury
Proenkephalin for Prediction of Contrast-Associated Kidney Events
Currently, contrast-induced kidney injury cannot be diagnosed on the day of cardiac catheterization. Recently, proenkephalin (penKid) was introduced as a new glomerular filtration marker.
- Conditions
- Contrast-induced Nephropathy, Acute Kidney Injury, Coronary Artery Disease
- Trial name
- PANCAKE (NCT03989505)
- Testing
- blood-draw for biomarker analyses
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Dr. med. Mahir Karakas
Acute Kidney Injury
The Biosonographic Index
In this exploratory study we explore the use of Shear Wave Elastography to differentiate between Acute Kidney Injury after vascular surgery and among the healthy population.
- Trial name
- NCT04144894
- Testing
- Shear Wave Elastography
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multi-organ Failure After Severe Trauma
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Severe trauma remains the leading cause of death in people under 50, and is associated with high morbidity, including severe disability, with a substantial socio-economic impact.
- Trial name
- METAKIT (NCT06167512)
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Metabolic Acidosis, Acute Kidney Injury
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU
Severe metabolic acidemia in the critically ill (pH equal or less than 7.20; PaCO2 equal or less than 45mmHg and bicarbonate concentration equal or less than of 20 mmol/l) is associated with a 50% rate of day 28 mortality.
- Trial name
- BICARICU-2 (NCT04010630)
- Testing
- Sodium bicarbonate infusion
- Where
- France
- Volunteers
- 640 people
- Sponsor
- University Hospital, Montpellier
Peri Implant Mucositis, Peri Implant Bone Loss
Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.
Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure.
- Conditions
- Peri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency
- Trial name
- NCT07766707
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- University of Barcelona
Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction
Lokelma for RAAS Maximisation in CKD & Heart Failure.
Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of…
- Conditions
- Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction, Hyperkalemia, ACE Inhibitor Induced Hyperkalaemia
- Trial name
- LIFT (NCT05004363)
- Testing
- Lokelma Oral Product
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- St George's, University of London
Bleeding ,Arrhythmias, Heart Failure, Acute Renal Failure, Acute Liver Failure, Dyspnoea, Gout
Extended Drug Utilization Study Among Patients Exposed to Ticagrelor, Clopidogrel and Prasugrel
The purpose of the study is to describe patient characteristics and drug usage among patients that are prescribed ticagrelor for the first time and to compare them with patients who are prescribed clopidogrel and prasugrel for…
- Trial name
- NCT01276275
- Testing
- Risk of selected safety events
- Where
- Sweden
- Volunteers
- 7,200 people
- Sponsor
- AstraZeneca
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Sepsis, Acute Kidney Injury
Efficacy of Online Hemodiafiltrationlysis in Cytokine Removal
Following the concept of "peak concentration hypothesis", which suggest the cutting peak of pro- and anti-inflammatory mediators would result in restoring a situation of immunohomeostasis.
- Trial name
- NCT01791712
- Testing
- On-line hemodiafiltration, High-flux Hemodialysis
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury, Obesity
Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG)
This study evaluated the effect of a single preoperative dose of gabapentin on renal stress and kidney function following laparoscopic sleeve gastrectomy in adults with severe obesity.
- Trial name
- NCT06254183
- Testing
- Laparoscopic Sleeve Gastrectomy, gabapentin 1200 mg
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Acute Kidney Injury
Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI
Acute kidney injury (AKI) occurs in up to 30% of patients undergoing coronary artery bypass graft (CABG) surgery, and often requires patients to go on dialysis.
- Trial name
- NCT03810417
- Testing
- Digoxin Antibodies Fab Fragments, Baseline EO > 360 pM, EO < 360 pM
- Where
- 2 sites in United States
- Volunteers
- 267 people
- Sponsor
- University of Maryland, Baltimore
Renal Colic, Acute Renal Failure
Urinary Markers for Unilateral Kidney Obstruction
Renal colic is usually caused from an obstructing stone along the ureter. Some of the patients present with a high level of creatinin in the blood, even though there is a normal functioning contralateral kidney.
- Trial name
- NCT01979042
- Where
- Israel
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Acute Kidney Injury, Chronic Kidney Diseases
Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases
Managing patients with renal failure requires an understanding of the molecular mechanisms that lead to its occurrence (i.e. upstream of the disease), its worsening and its persistence (i.e.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Solid-organ Transplantation, Cancer
- Trial name
- NEPHROGENE2 (NCT05318196)
- Testing
- Biological samples collection
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Toulouse
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Acute Liver Failure, Acute on Chronic Liver Failure (ACLF)
Continuous Renal Replacement Therapy Intensity in Hyperammonemia
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are life-threatening conditions often associated with hyperammonemia, hepatic encephalopathy, and multi-organ dysfunction.
- Conditions
- Acute Liver Failure, Acute on Chronic Liver Failure (ACLF), Acute Kidney Injury, Ammonia Metabolism
- Trial name
- CRITICAL (NCT06987604)
- Testing
- High-dose continuous renal replacement therapy, Conventional-dose continuous renal replacement therapy
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Kidney Injury
Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKI
This observational study aims to explore the factors that influence the risk of new infections in critically ill patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) in the UK.
- Trial name
- CRRTinfUK (NCT07903519)
- Where
- United Kingdom
- Volunteers
- 630 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Covid19, Acute Kidney Injury
Acute Kidney Injury in Patients With CoVID-19
We aimed to investigate the effect of Acute Kidney Injury (AKİ) on the prognosis of patients hospitalised for COVID-19.
- Trial name
- AKI-COVID-19 (NCT04872764)
- Testing
- duration of hospitalization, mortality rate
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Uşak University
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