Clinical trials: Renal Injury, Acute
Acute Kidney Injury
Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
The main objective of this study is to evaluate the efficacy of intravenous sodium nitrite compared with placebo in reducing the occurrence of CSA-AK as diagnosed by KDIGO criteria during the first 72 hrs after cardiac surgery in…
- Trial name
- NCT03331146
- Testing
- Saline, Sodium Nitrite
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Endocarditis, Acute Kidney Injury
Renal Tolerance of Amoxicillin and Cloxacillin Combination
2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identification).
- Trial name
- Amox-Cloxa (NCT05142891)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
AKI - Acute Kidney Injury, CABG
Perfusion Related Evaluation of Systemic and Renal Vulnerability to Events in CABG
The goal of this observational study is to learn whether high abdominal pressure or low blood flow pressure to the kidneys is linked to kidney injury after heart surgery.
- Trial name
- PRESERVE-CABG (NCT07085286)
- Testing
- Continous IAP measurement
- Volunteers
- 45 people
- Sponsor
- Medical University of Lublin
Acute Kidney Injury, Premature Infant
NIRS Monitoring to Detect AKI in Preterm Infants
This study will examine the relationship of oxygen levels, using Near-infrared spectroscopy (NIRS) monitoring, and kidney injury in infants born prematurely.
- Trial name
- nNIRS-AKI (NCT03384173)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison
Critical Illness, Acute Kidney Injury
Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study
This study aims to determine changes in kidney function during and after critical illness, comparing conventional creatinine based methods with the gold standard to accurately establish the presence of new or worsened chronic…
- Conditions
- Critical Illness, Acute Kidney Injury, Muscle Loss, Major Trauma
- Trial name
- KRATOS (NCT03736005)
- Testing
- Exposure of significant critical illness
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)
The aim of this study is to evaluate the efficacy and safety of GDC-8264 compared with placebo in participants undergoing cardiac surgery who are determined to be at moderate to high risk of developing AKI and subsequent MAKE at…
- Trial name
- NCT06602453
- Testing
- GDC-8264
- Where
- 34 sites in United States, Australia and 10 more
- Volunteers
- 67 people
- Sponsor
- Genentech, Inc.
Contrast-induced Acute Kidney Injury, Microalbuminuria
Microalbuminuria Predicting CIAKI After CAG
The purpose of this study is to investigate the association between pre-existing microalbuminuria and contrast-induced acute kidney injury (CIAKI) following coronary angiography (CAG).
- Trial name
- MPCC (NCT02808845)
- Testing
- microalbuminuria
- Where
- China
- Volunteers
- 800 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiac Surgery, Aortocoronary Bypass
Remote Ischemic Preconditioning After Cardiac Surgery
Acute kidney injury (AKI) is a well-recognized complication after cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study is to reduce the incidence of AKI by implementing remote ischemic preconditioning and to…
- Trial name
- RIPCRenal (NCT02997748)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University Hospital Muenster
Heart Failure, Acute Kidney Injury
Evaluation of VEXUS Score of Patients With Heart Failure in the Intensive Care Unit.
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06389708
- Volunteers
- 100 people
- Sponsor
- Inonu University
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
AKI - Acute Kidney Injury, Fluid Balance
Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy
The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury…
- Conditions
- AKI - Acute Kidney Injury, Fluid Balance, Acute Circulatory Failure, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- mVExUS-CRRT (NCT07346118)
- Testing
- mVExUS-guided fluid management
- Where
- 2 sites in Thailand
- Volunteers
- 126 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury
Lithium in Acute Kidney Injury
A growing body of pre-clinical evidence suggests that glycogen synthase kinase 3β (GSKβ) is implicated in the development and progression of acute kidney injury (AKI). Lithium is a naturally occurring standard inhibitor of GSKβ.
- Trial name
- LSCAKI (NCT03056248)
- Testing
- Lithium Carbonate
- Volunteers
- 50 people
- Sponsor
- Lifespan
Acute Kidney Injury, Renal Replacement Therapy
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Units
- Trial name
- Taking Focus 2 (NCT03541785)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Kidney Failure, Acute
Mean Arterial Pressure (MAP) and Renal Perfusion: Evaluation of Critically Ill Patients With Normal Creatinine or Reduced Renal Function
The purpose of this study is to evaluate the renal perfusion depending on the MAP.
- Trial name
- NCT00117416
- Testing
- controlling the MAP
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Acute Renal Failure, Infection
Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
The purpose of this trial is to study the pharmacokinetics of anidulafungin during continuous venovenous hemofiltration. Background: Anidulafungin is a cyclic lipopeptide antifungal agent of the echinocandin class.
- Trial name
- NCT00892359
- Testing
- Anidulafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Acute Kidney Injury, Chronic Kidney Disease
Nutritional Therapy to Prevent Progression of Acute Kidney Injury to Chronic Kidney Disease
This study will evaluate patients who have an episode of moderate to severe acute kidney injury (AKI) and are followed in a focused post-AKI clinic.
- Trial name
- NutriAKI (NCT02831062)
- Testing
- low protein diet + ketosteril
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Patients Undergoing Lung Transplantation Under Extracorporeal Membrane Oxygenation
A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial
The aim of this study is to investigate whether propofol based total intravenous anesthesia reduces incidence of acute kidney injury following the lung transplantation under extracorporeal membrane oxygenation
- Trial name
- NCT02009280
- Testing
- Administration of anesthesia: Propofol, Administration of anesthesia: Sevoflurane
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Acute Kidney Injury
PREVENTion With Sglt-2 Inhibition of Acute Kidney Injury in Intensive Care
Background Acute Kidney Injury (AKI) is a potentially life-threatening condition caused by unsafe levels of fluid and waste products accumulating in the body.
- Trial name
- PREVENTS-AKI (NCT05468203)
- Testing
- Dapagliflozin 10mg Tab
- Where
- 3 sites in Australia
- Volunteers
- 51 people
- Sponsor
- The George Institute
Acute Renal Failure, Sepsis
Angiotensin in Septic Kidney Injury Trial
The purpose of this study is to determine the effect of a systemic infusion of angiotensin II on haemodynamics and urine output in critically ill patients with severe sepsis/septic shock and acute renal failure.
- Conditions
- Acute Renal Failure, Sepsis, Septic Shock
- Trial name
- ASK-IT (NCT00711789)
- Testing
- Angiotensin II
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Austin Health
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