Clinical trials: Renal Injury
Acute Kidney Injury, Renal Failure
Retrospective Data Analysis of CKRT (Continuous Kidney Replacement Therapy) Treatments in Adult Mode With multiFiltratePRO
The multiFiltratePRO is a device for extracorporeal blood purification treatments. In this retrospective analysis, the treatments of patients who received at least one treatment with the investigational device as mentioned…
- Trial name
- CKRT-AKI (NCT06236984)
- Testing
- multiFiltratePRO with all CKRT treatment modes
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Subarachnoid Hemorrhage, Acute Kidney Injury
A Low ChloridE hyperTonic Solution for Brain Edema
This pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (SAH) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic…
- Trial name
- ACETATE (NCT03204955)
- Testing
- Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Emory University
Acute Kidney Injury With Cirrhosis
On Demand Versus Protocol-guided Renal Replacement Therapy for Management of Stage 3 Acute Kidney Injury in Patients With Cirrhosis
Intervention: All patients at presentation would be assessed for the underlying cause of and will be managed by removal of all precipitants(careful review of medications, diuretics, nephrotoxic drugs,vasodilators or non-steroidal…
- Trial name
- NCT02937935
- Testing
- Protocol Guided Renal Replacement Therapy, On Demand Renal Replacement Therapy
- Where
- India
- Volunteers
- 2 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Fractures, Bone, CKD Stage 4
The Effect of Prophylactic Anticoagulation on Major Bleeding Events in Hospitalized Chronic Kidney Disease and Lower Limb Fracture Patients.
the risk of bleeding may be greater than the benefit of antithrombotic protection when prophylactically anticoagulating a patient with a lower limb fracture and advanced CKD.
- Conditions
- Fractures, Bone, CKD Stage 4, CKD Stage 3, CKD Stage 5
- Trial name
- FAA (NCT06795698)
- Testing
- Enoxaparin
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Hospital Civil de Guadalajara
Contrast-associated Acute Kidney Injury
An Observational Study of Percutaneous Glomerular Filtration Rate (TGFR) in the Early Warning of Contrast-induced Acute Kidney Injury During the Peri-examination Period of Emergency Enhanced CT
This is a single-center, prospective observational study. We aim to evaluate the performance of transdermal glomerular filtration rate (TGFR) compared with baseline estimated glomerular filtration rate (eGFR) for early prediction…
- Trial name
- NCT07850947
- Testing
- Transdermal glomerular filtration rate (TGFR) monitoring
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury, Outcome, Fatal
Effect of Weekend Admission on Mortality Associated With Severe Acute Kidney Injury in England: a Propensity Score Matched, Population-based Study
Increased in-hospital mortality associated with weekend admission has been reported for many acute conditions, but no study has investigated "weekend effect" for acute kidney injury requiring dialysis (AKI-D).
- Trial name
- NCT02947698
- Volunteers
- 53,878 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Surgery
Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss.
- Trial name
- SHIELD-pilot (NCT07440121)
- Testing
- restrictive fluid infusion, preload, nitro
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Acute Kidney Injury, Acute Kidney Failure Stage 3
The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning
Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU…
- Trial name
- NCT04622384
- Testing
- Dialysis weaning
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Johan Fridolf Hermansen
AKI - Acute Kidney Injury
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Contrast-associated acute kidney injury (CA-AKI) is a common complication of procedures with intravascular contrast. Generally, CA-AKI is defined as serum creatinine (Scr) ≥ 25 to 50% or Scr rise around 0.3 to 0.5 mg/dl.
- Trial name
- NCT05540184
- Testing
- Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Fluid Overload
Fluid Balance Neutralization During CRRT (Continuous Renal Replacement Therapy)
Fluid overload is associated with increased mortality in critically ill patients with acute kidney injury. Fluid balance controlled is associated with improved outcome in observational studies, and is deemed safe in…
- Trial name
- GO-NEUTRAL (NCT04801784)
- Testing
- Increased net ultrafiltration with advanced hemodynamic monitoring, Zero or near-zero net ultrafiltration
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Hospices Civils de Lyon
Skin Closure of Surgical Incisions by Tissue Glue vs Suture
Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors
By means of a prospective, randomised trial the investigators want to examine skin closure in living donors - subjected to laparoscopic, hand-assisted nephrectomy - by tissue glue (Cyanoacrylate (Liquiband)) versus conventional…
- Trial name
- TG-CYANO (NCT01521871)
- Testing
- Skin wound closure by tissue glue, Skin wound closure by conventional suture + dressing
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
Acute Kidney Injury, Hemodynamic Instability
Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Robotic-assisted laparoscopic prostatectomy (RALP) is the gold standard surgical technique in prostate surgery. Many Robotic-laparoscopic surgical techniques also require the intraoperative deep Trendelenburg position and…
- Trial name
- NCT06000098
- Testing
- Restrictive fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Acibadem University
Acute Renal Injury
Acute Kidney Injury in Critically Ill Patients
Acute kidney injury (AKI) in critically ill trauma patients has been shown to significantly increase mortality, length of stay, and costs, however detection has proven difficult as markers like elevated creatinine and decreased…
- Trial name
- NCT02765464
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Acute Kidney Injury
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor
The purpose of this study is to determine whether perioperative intravenous administration of pantoprazole will improve kidney function parameters following cardiac surgery with cardiopulmonary bypass compared to famotidine and…
- Trial name
- NCT06154226
- Testing
- Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Disease, Renal Insufficiency, Acute
Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.
- Conditions
- Cardiovascular Disease, Renal Insufficiency, Acute, Cardiopulmonary Bypass
- Trial name
- NCT00190034
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Covid19, AKI
Efficacy and Safety of a Highly Selective Semipermeable Membrane (AN-69 Oxiris) vs (Standard AN-69) in COVID-19
Abstract Title: Randomized,open-label, controlled trial to evaluate efficacy and safety of a highly selective semipermeable membrane (AN69-Oxiris) in comparison with a selective semipermeable membrane ( standard AN69) in COVID-19…
- Trial name
- oXAKI-COV (NCT04597034)
- Testing
- AN69-Oxiris, AN69-Standard
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hip Fractures, Acute Kidney Injury
Evaluation of Novel Biomarkers in Early Recognition of Acute Kidney Injury After Orthopedic Operations.
Surgical treatment of hip fracture may be complicated by acute kidney injury. The aim of this study is to investigate whether the investigators can find a better biomarker than creatinine to recognize this problem at an earlier…
- Trial name
- NCT05285709
- Testing
- Biomarker, RRI measurement
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Acute Coronary Syndrome
Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)
The aim of the project is to compare the nephro-protective effects of high-dose atorvastatin and high-dose rosuvastatin on the incidence of Contrast Induced-Acute Kidney Injury in patients with non-ST-elevation acute coronary…
- Trial name
- PRATO-ACS-2 (NCT01870804)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- Italy
- Volunteers
- 760 people
- Sponsor
- Centro Cardiopatici Toscani
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital