Clinical trials: Renal Insufficiency, Acute
Acute Kidney Injury
Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
The aim of the study is to determine whether there is a correlation between changes in the renal resistive index and the restoration of kidney function in critically ill patients undergoing continuous renal replacement therapy.
- Trial name
- NCT06174610
- Testing
- Measurement of Renal Resistive Index
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Acute Kidney Injury
Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study
Acute kidney injury requiring dialysis (AKI-D) has increased considerably over last 15 years. The national rise in incidence of acute kidney injury has several ramifications in terms of cost to the health services resulting not…
- Trial name
- NCT02675296
- Where
- United Kingdom
- Volunteers
- 54,680 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Acute Kidney Injury
Association Between Postoperative Administration of L-Arginine and CSA-AKI
To investigate the association between the the early administration of L-Arginine after CPB-assisted cardiac surgery and the incidence of CS-AKI in adult patients. To test if it can reduce the incidence of post-operative AKI.
- Trial name
- NCT06248359
- Testing
- L-Arginine hydrochloride
- Where
- China
- Volunteers
- 5,135 people
- Sponsor
- Xijing Hospital
Radiographic Contrast Agent Nephropathy
Contrast Media Reduction and Removal in Patients With Chronic Kidney Disease (CKD) (PRESERV)
The purpose of this clinical trial is to demonstrate the efficacy and safety of the Osprey Medical CINCOR™ Contrast Removal System.
- Trial name
- NCT01168024
- Testing
- CINCOR™ System and contrast conservation unit (CCS-1), Standard of Care plus peri-procedural hydration
- Where
- 21 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- Osprey Medical, Inc
Kidney Failure, Chronic
Isoflavones and Acute-phase Response in Chronic Renal Failure
This is a randomized, double-blinded dietary intervention in hemodialysis patients to determine the clinical and metabolic effects of soy isoflavones on disease activity, including improvement of blood markers of acute-phase…
- Trial name
- NCT00029796
- Testing
- soy isoflavones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Acute Kidney Injury
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)
The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on…
- Trial name
- NCT01552525
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Acute Kidney Injury, Extracorporeal Circulation; Complications
Tissue Inhibitor of Metalloproteinases 2 Level in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as…
- Conditions
- Acute Kidney Injury, Extracorporeal Circulation; Complications, Surgery
- Trial name
- NCT06871826
- Testing
- TIMP2 level
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan University
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Renal Failure, Infection
Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
The purpose of this trial is to study the pharmacokinetics of anidulafungin during continuous venovenous hemofiltration. Background: Anidulafungin is a cyclic lipopeptide antifungal agent of the echinocandin class.
- Trial name
- NCT00892359
- Testing
- Anidulafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
AKI - Acute Kidney Injury, Pneumonia
To Compare the Efficacy and Safety of Using oXiris and M100 During CRRT
The purpose of this study aimed to compare the efficacy of Oxiris (Baxter) and M100 filters on IL-6 as primary outcomes and other blood cell counts, blood biochemistry (serum urea, creatinine, potassium, sodium), inflammation…
- Trial name
- NCT06440759
- Testing
- oXiris filter, M100 filter
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
Anesthesia, Spinal Aneshtesia
Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests
Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes…
- Conditions
- Anesthesia, Spinal Aneshtesia, Acute Kidney Failure, Spinal Anesthesia Induced Hypotension
- Trial name
- NCT07015359
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Nihan Aydin Guzey
Acute Kidney Injury, Septic Shock
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown.
- Conditions
- Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality
- Trial name
- TOX-AKI (NCT03920982)
- Testing
- Determination of the blood concentration of indoxyl sulfate (IS)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Injury, Critical Illness
Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients
The goal of this observational study is to explore the association between urine output and acute kidney injury in severely ill patients admitted to intensive care units.
- Conditions
- Acute Kidney Injury, Critical Illness, Critical Care, Intensive Care, Critical Care, Fluid Resuscitation
- Trial name
- NCT06722924
- Volunteers
- 15,000 people
- Sponsor
- Uppsala University
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Right Heart Failure
Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation
The primary purpose of this study is to investigate the evolution of Right Ventricular (RV) function before and after left ventricular assist device (LVAD) implantation, using novel echocardiographic quantification of RV size and…
- Trial name
- EuroEchoVAD (NCT03552679)
- Testing
- Echocardiography
- Where
- 9 sites in Germany, Hungary and 5 more
- Volunteers
- 600 people
- Sponsor
- Erasmus Medical Center
Sepsis, Acute Kidney Injury
Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury
This multicenter, randomized, open-label, active-controlled, parallel-group trial will evaluate the efficacy and safety of nafamostat mesylate anticoagulation compared with regional citrate anticoagulation in adult patients with…
- Conditions
- Sepsis, Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- NICE-AKI (NCT07518303)
- Testing
- Citrate anticoagulation, Nafamostat Mesylate
- Volunteers
- 1,162 people
- Sponsor
- Jianfeng Xie
Acute Kidney Injury, Exercise-associated Hyponatremia
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
The specific aim of this study is to evaluate the safety of non-steroidal anti-inflammatory drugs (NSAIDs) and their impact on renal function and/or contribution to exercise-associated hyponatremia (EAH) during an ultramarathon…
- Conditions
- Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion
- Trial name
- NAKED (NCT02272725)
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
End Stage Renal Disease, Hypotension During Dialysis
Effect of Protein Intake During Hemodialysis on Blood Pressure and Arterial Stiffness Indices
Open label, randomized, cross-over clinical study comparing the acute effect of high versus low protein meals during dialysis on intradialytic blood pressure, 24-hour ambulatory blood pressure and arterial stiffness indices on…
- Conditions
- End Stage Renal Disease, Hypotension During Dialysis, Protein Malnutrition, Arterial Sclerosis
- Trial name
- NCT03947710
- Testing
- High-protein meals, Low- protein meals, No meals
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- Aristotle University Of Thessaloniki