Clinical trials: Renal Insufficiency, Acute
Acute Kidney Injury
Guidance of Ultrasound in Intensive Care to Direct Euvolemia
The purpose of this study is to assess the effectiveness of routine ultrasound assessments of volume status and fluid responsiveness for goal-directed therapy (GDT)-based fluid resuscitation in reducing acute kidney injury (AKI)…
- Trial name
- GUIDE (NCT03938038)
- Testing
- Serial ultrasound assessments for GDT, Usual care
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pyelonephritis, Prognostic
Factors and Prognosis of Obstructive Pyelonephritis Patients
Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit.
- Trial name
- PYELO-OBS (NCT06299215)
- Where
- France
- Volunteers
- 575 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Acute Kidney Injury, Mesenchymal Stem Cells
Clinical Trial of Mesenchymal Stem Cells in the Treatment of Severe Acute Kidney Injury
Acute kidney injury(AKI) is a common, severe emergency case in clinics,especially severe AKI ,which is associated with higher morbidity and mortality.
- Trial name
- NCT04194671
- Testing
- Mesenchymal stem cells, Saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Diabetes Mellitus, Coronary Artery Bypass
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary…
- Conditions
- Diabetes Mellitus, Coronary Artery Bypass, Remote Ischaemic Conditioning
- Trial name
- NCT06977230
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
Acute Kidney Injury
Rapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU
This is a multi-center, prospective, observational study of patients that are admitted to the intensive care unit (ICU). This study does not include any treatment or intervention and it is considered Nonsignificant Risk.
- Trial name
- REAL-ICU (NCT01294228)
- Where
- 28 sites in United States, Canada
- Volunteers
- 1,001 people
- Sponsor
- Abbott RDx Cardiometabolic
Hepatorenal Syndrome, Liver Cirrhosis
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
Patients with advanced cirrhosis of the liver develop kidney problems occasionally. This condition is called Hepatorenal Syndrome, requires hospitalization and frequently results in death.
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Trial name
- NCT06256432
- Testing
- Ambrisentan, Terlipressin
- Where
- 6 sites in India
- Volunteers
- 54 people
- Sponsor
- Noorik Biopharmaceuticals AG
Acute Kidney Injury
Prevention of Akute Kidney Injury, Hearttransplant, ANP
Prospective, blinded, placebo-controlled trial. Patients: Adult patients (>18 years of age) undergoing de novo Htx, with a preoperative GFR > 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of > 6 hours.
- Trial name
- NCT02665377
- Testing
- ANP
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Sahlgrenska University Hospital
Acute Kidney Injury
Prognosis and Risk Factors for Acute Kidney Injury
The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes.
- Trial name
- NCT06898944
- Where
- South Korea
- Volunteers
- 320,000 people
- Sponsor
- Seoul National University Hospital
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Acute Kidney Injury
Epidemiology of Acute Kidney Injury in England - 1998 to 2013
The true population incidence of acute kidney injury (AKI), previously called acute renal failure, in England is not known. A better understanding of the epidemiology of AKI at a national level is essential to inform initiatives…
- Trial name
- NCT02216695
- Where
- United Kingdom
- Volunteers
- 64,882 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Acute Kidney Injury, Sepsis
Value of Urine sTREM-1 on Early Predicting AKI in Sepsis
The purpose of this study is to determine the value of urine sTREM-1 on early predicting secondary acute kidney injury in sepsis
- Trial name
- NCT02920736
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Aortic Dissection, Acute Kidney Injury
Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
The research aimed to predict postoperative acute kidney injury in patients with acute type A aortic dissection preliminarily by exploring the correlation of preoperative cystatin C level and incidence of postoperative acute…
- Trial name
- NCT05039814
- Testing
- postoperative acute kidney injury, none postoperative acute kidney injury
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Qilu Hospital of Shandong University
Kidney, Injury
Intensive Insulin Therapy and Acute Kidney Injury. Analysis Using RIFLE Criteria.
The purpose of this study is to determine if intensive insulin therapy really reduces the incidence of acute kidney injury in critically ill patients, using for analysis the RIFLE criteria for definition of AKI.
- Trial name
- NCT00738504
- Where
- Brazil
- Volunteers
- 337 people
- Sponsor
- Hospital Sao Domingos
Acute Renal Failure, Chronic Kidney Failure
The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.
- Conditions
- Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)
- Trial name
- NCT00358306
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Proton Pump Inhibitor, Acute Kidney Injury
Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury
Recent evidence concerns acute kidney injury (AKI) following proton pump inhibitor (PPI) application. Few actual studies have compared the incidence, risk factors, and predictive models of AKI associated with PPI.
- Trial name
- NCT05533619
- Testing
- Proton pump inhibitor
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Qianfoshan Hospital
Acute Renal Failure, Hemorrhage
Impact of Renal Replacement Therapy on Coagulation Profile of Patients with Acute Renal Failure
Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters.
- Conditions
- Acute Renal Failure, Hemorrhage, Coagulation Disorder
- Trial name
- HEMOSTIR (NCT03536195)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Brest
Kidney Injury, Acute
Perioperative Use of NAC to Prevent AKI in Patients With Pre-existing Moderate Renal Insufficiency Following Cardiac Surgery
Acute kidney injury (AKI) or renal impairment is an established complication of cardiac surgery occurring with an incidence up to 30%, To date, no agent has conferred renal protection.
- Trial name
- NCT05555511
- Testing
- Control Group
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Acute Renal Failure
Recombinant Human Erythropoietin Use in Intensive Care Unit (ICU) Patients: Does it Prevent Acute Renal Failure
Pilot study aiming to assess the effect of two doses of rhu EPO on urine NGAL concentration and on serum cystatin C and creatinine levels in critically ill patients at risk of ARF.
- Trial name
- NCT00676234
- Testing
- epoetinum
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
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