Clinical trials: Renal Insufficiency, Acute
Acute Kidney Injury
A Prompt REstart Study of Renin-Angiotensin System Inhibitors After Acute Kidney Injury
The goal of this pilot clinical trial is to learn if early restart of renin-angiotensin system inhibitor (RASi) medications is feasible and well-tolerated in hospitalized patients with acute kidney injury (AKI).
- Trial name
- APRES-AKI (NCT07734636)
- Testing
- Early RASi restart strategy, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Acute Kidney Injury
Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement
Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function.
- Trial name
- NCT04132921
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xuzhou Medical University
Kidney Failure, Acute, Shock
Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
This trial aims to study the effect of combining continuous and a new polyamide membrane with larger pores in the treatment of critically ill patients with acute renal failure and low blood pressure (shock) requiring…
- Trial name
- NCT00912184
- Testing
- Standard polyamide high flux membrane, High cut-off (super high flux) polyamide membrane
- Where
- Australia
- Volunteers
- 76 people
- Sponsor
- Austin Health
Femur Fracture, Acute Renal Failure
Preventive Norepinephrine Infusion During Surgery for Upper Femoral Fracture and Post-operative Acute Renal Failure
The fracture of the upper extremity of the femur (FESF) is one of the most common fractures in traumatology. In France, FESF affects more than 65,000 individuals per year and could involve up to 150,000 people per year by 2050…
- Trial name
- NORAKI (NCT05566132)
- Where
- France
- Volunteers
- 676 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Primary Outcome : Compare Percent CRP Reduction, Secondary Outcome : 30-day Mortality, Renal Recovery, Length of Hospital Stay
Efficacy of Convection-based HDF Compare With Diffusion-based HD in Sepsis-associated AKI
Acute kidney injury (AKI) is a common complication among patient admitted in the hospital worldwide, with estimates of prevalence ranging from less than 1% to 66%.1, 2 In critically ill patients approximately 49% were acute…
- Trial name
- NCT06227104
- Testing
- Convection-based Hemodiafiltration
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Ramathibodi Hospital
Acute Kidney Injury
Nephroprotective Measures in Critically Ill Patients With Moderate/Severe Acute Kidney Injury
This study investigates to which extent recommended nephroprotective measures are implemented in critically ill patients with moderate or severe acute kidney injury.
- Trial name
- KDIGO-Bundle (NCT06472999)
- Testing
- Nephroprotective measures
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 257 people
- Sponsor
- Universität Münster
Secondary Hypothyroidism
Thyroid Function in Critically Ill Patients With Acute Kidney Injury
The objective of this study was to assess the changes in thyroid hormones and its activity during CRRT in patients with Acute Kidney Injury.
- Trial name
- NCT04767763
- Testing
- Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Gdansk
Renal Insufficiency, Acute, Cardiac Surgery Associated - Acute Kidney Injury
Renal Resistive Index in Early Detection of Postoperative Acute Kidney Injury
The primary aim of our study was to investigate the role of renal doppler ultrasonography (USG) and preoperative/postoperative renal resistive index (RRI) in the early prediction of AKI.
- Trial name
- NCT06791304
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Continuous Renal Replacement Therapy
Continuous Versus Conventional Volume Management During CRRT (Continuous Renal Replacement Therapy)
Use of on-line blood volume monitoring during continuous renal replacement therapy can improve volume management in acute kidney injury patients requiring renal replacement
- Trial name
- NCT01405092
- Testing
- use of continuous renal replacement machine for renal replacement, use of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Dallas VA Medical Center
Acute Abdomen, Radiocontrast Nephropathy
Intravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal Function
Computer tomography (CT) is the primary imaging option for acute abdominal pain in adults. Intravenous (IV) contrast media is used to improve the CT quality.
- Trial name
- INCARO (NCT04196244)
- Testing
- Abdominal or body CT with intravenous contrast, Abdominal or body CT without intravenous contrast (native CT)
- Where
- 3 sites in Finland
- Volunteers
- 994 people
- Sponsor
- Helsinki University Central Hospital
Heading
Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?
Patients with septic shock in the intensive care unit have an elevated risk of developing acute kidney injury (AKI).
- Trial name
- AKI-CHECK (NCT02812784)
- Testing
- Nephrocheck TM
- Where
- 11 sites in France
- Volunteers
- 184 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Cardiac Surgery
Amino Acid Infusion in Cardiac Surgery
The goal of this study is to see if an infusion of amino acids given to adult male and female patients during cardiac surgery can help prevent acute kidney injury that commonly occurs when patients undergo cardiac surgery needing…
- Trial name
- NCT07030933
- Testing
- Travesol 10%
- Volunteers
- 130 people
- Sponsor
- Milton S. Hershey Medical Center
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute Kidney Injury, Chronic Kidney Diseases
Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration
To date, little knowledge exists related to the use of hemodialysis (HD) in infants and has been limited to mainly single center studies.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Renal Dialysis
- Trial name
- ICONIIC (NCT05161078)
- Testing
- CARPEDIEM
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Renal Insufficiency
Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics
Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially…
- Trial name
- CANOPY (NCT02955979)
- Testing
- CT scan with iodinated contrast agents
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cystic Fibrosis
Prospective Observational Study to Evaluate Biomarkers of Aminoglycoside Nephrotoxicity in Patients With Cystic Fibrosis
The project is designed to test new biomarkers that are more sensitive than the current standard in detecting injury to the proximal kidney tubule and will establish better criteria for when kidney safety concerns may halt…
- Trial name
- NCT01543620
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Foundation for the National Institutes of Health
Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis
Clinical Application of Quantitative Ultrasonographic Analysis in Early Kidney Injury
The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).
- Trial name
- NCT05662774
- Testing
- Ultrasound contrast agent (Sonovue)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Kidney Injury, Acute
Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney Injury
This pilot study is designed to test the logistics and recruitment of a trial testing the benefit of sodium nitrate in the prevention of contrast-associated kidney injury in a group of patients at high-risk.
- Trial name
- NCT07016074
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
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