Clinical trials: Renal Insufficiency, Acute
Sepsis, Acute Kidney Injury
Role of FGF-23 as a Prognosis Biomarker in Intensive Care Patients
The purpose of the study is to evaluate the potential role of plasmatic Fibroblast Growth Factor 23 (FGF-23) as a prognosis predictor of clinical outcomes in Critical Care patients.
- Trial name
- NCT01801501
- Where
- Chile
- Volunteers
- 164 people
- Sponsor
- University of Chile
Lung Transplantation
Prediction Model for Postoperative AKI in Patients Undergoing Lung Transplantation Using Machine Learning
Since 1963, lung transplantation progress has surged due to immunosuppressive agent advancements. In 2004, 1,815 global lung transplantations were reported.
- Trial name
- NCT06218745
- Testing
- General anesthesia
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Pusan National University Yangsan Hospital
Multiple Myeloma
A Safety and Efficacy of Pomalyst® Capsules Under the Actual Use in All Patients Who Are Treated With Pomalyst at a Dose of 1 mg, 2 mg, 3 mg, or 4 mg
1. Planned enrollment period One year (The planned number of patients to be enrolled is set to 400 patients.) Since all patients who are prescribed with Pomalyst are registered in RevMate®, enrollment using the Registration Form…
- Trial name
- NCT02921828
- Where
- 2 sites in United States, Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Machine Learning, Acute Kidney Injury
Machine Learning Predict Acute Kidney Injury in Patients Following Cardiac Surgery
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication which may result in adverse impact on short- and long-term mortality.
- Trial name
- NCT04966598
- Where
- China
- Volunteers
- 2,108 people
- Sponsor
- Yunlong Fan
Acute Kidney Failure, Critical Illness
Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.
Background: Acute kidney injury (AKI) is common in critically ill patients and is associated with worse outcomes, including longer ICU stay, need for dialysis, and higher mortality.
- Conditions
- Acute Kidney Failure, Critical Illness, Protein Intake, Nutritional Support
- Trial name
- NCT07631221
- Where
- 6 sites in Argentina
- Volunteers
- 344 people
- Sponsor
- Hospital Italiano de Buenos Aires
Critical Illness, Acute Kidney Injury
Balanced Solution Versus Saline in Intensive Care Study
A 2x2 factorial randomized study to evaluate the effect of a balanced crystalloid solution compared with 0.9% saline, and of rapid vs. slow infusion on clinical outcomes of critically ill patients
- Trial name
- BaSICS (NCT02875873)
- Testing
- Plasma-Lyte, Saline 0.9%, Slow infusion speed
- Where
- Brazil
- Volunteers
- 11,075 people
- Sponsor
- Hospital do Coracao
Fluid Overload, Acute Kidney Injury
Perfusion Parameters and Outcome During a Standardized Deresuscitation Strategy with Net Ultrafiltration: a Retrospective Cohort Study.
Hemodynamic tolerance of fluid removal during deresuscitation is a cornerstone of the impact on outcome of such a strategy. However, how to define and to predict hemodynamic tolerance to fluid removal remains controversial.
- Conditions
- Fluid Overload, Acute Kidney Injury, Continuous Renal Replacement Therapy
- Trial name
- DeepCART (NCT06899880)
- Testing
- Describe the perfusion parameters during a deresuscitation strategy and their association with the outcome.
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Systemic Inflammatory Response Syndrome, Kidney Failure, Acute
High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock
This study will assess the influence of the High Cut-Off (HCO) CVVHD treatment on the disease progression in septic patients. The primary aim of the study is to evaluate whether HCO CVVHD leads to a significant improvement of the…
- Trial name
- HICOSS (NCT00875888)
- Testing
- continuous venovenous hemodialysis
- Where
- 4 sites in Austria, Germany
- Volunteers
- 80 people
- Sponsor
- Vantive Health LLC
Cardiac Surgery Associated - Acute Kidney Injury, Critical Illness
Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients
This project aims to detect novel biomarkers from preoperative and early postoperative serum and urine samples of patients to screen and analyze the risk factors for predicting adverse postoperative renal outcomes in high-risk…
- Trial name
- NCT07418242
- Testing
- Standard care "bundle"
- Where
- 2 sites in China
- Volunteers
- 319 people
- Sponsor
- Guowei Tu
Postoperative Complications
Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment
Brief Summary: The goal of this study is to implement and test an intelligent perioperative system (IPS) that in real-time predicts risk for postoperative complications using routine clinical data collected in electronic health…
- Trial name
- IDEALIST (NCT02741986)
- Testing
- Risk estimation
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
Kidney Injury, Pre-Term
Improving Preterm Kidney Outcomes With Caffeine
This study is being done to see if additional caffeine citrate (20 milligrams per kilogram IV bolus) helps babies with low kidney oxygenation already being treated with caffeine citrate (20 milligrams per kilogram IV bolus on day…
- Trial name
- NCT07262060
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Wisconsin, Madison
Kidney Failures, Acute
Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury
Randomized prospective trial of patients with diuretic unresponsive acute kidney injury where patients will receive standard supportive therapy with diuretics versus intra-renal delivery of the vasodilator fenoldopam mesylate.
- Trial name
- IR-FTA (NCT01073189)
- Testing
- Intra-Renal Fenoldopam, Furosemide
- Where
- United States
- Sponsor
- Southeast Renal Research Institute
Renal Replacement Therapy for Acute Kidney Injury in Intensive Care Unit
Artificial Kidney Initiation in Kidney Injury
The best timing for renal replacement therapy (RRT) in intensive care unit (ICU) patients with acute kidney injury (AKI) is unknown.
- Trial name
- AKIKI (NCT01932190)
- Testing
- Early RRT strategy, Delayed RRT strategy
- Where
- France
- Volunteers
- 620 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Acute Kidney Injury
Prevention of Acute Kidney Injury After Transcatheter Aortic Valve Implantation
Randomized controlled, single-center trial randomizing patients with chronic kidney disease and symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- NCT04537325
- Testing
- RenalGuard system
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Prediction Model
Development and Validation of a Real-time Prediction Model for Acute Kidney Injury in Hospitalized Patients
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published.
- Trial name
- NCT06597838
- Where
- China
- Volunteers
- 161,876 people
- Sponsor
- Peking University First Hospital
Vancomycin, Staphylococcal Infections
Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China
The objective of this study was to investigate the current situation of vancomycin (VAN)-associated acute kidney injury (VA-AKI) in China and identify the risk factors for VA-AKI, as well as to comprehensively examine the risk…
- Conditions
- Vancomycin, Staphylococcal Infections, Adverse Effect, Acute Kidney Injury
- Trial name
- NCT03456544
- Testing
- Vancomycin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury, Renal Replacement Therapy
AKI Cardiosurgery Diagnostic Study (AKI-CDS)
Acute kidney injury (AKI) is a common and major complication of cardiac surgery. The aim of this study is to evaluate the use of a fragment of proencephalin in plasma and other biomarkers as specific markers for early diagnosis…
- Trial name
- AKI-CDS (NCT03632538)
- Testing
- Biomarker ("penKid", adrenomedulin, C-terminal alpha-1 antitrypsin peptide)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Kidney Injury, Acute
Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients
Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney…
- Trial name
- NCT01824771
- Testing
- Plasma lactate were measured
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
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