Clinical trials: Renal Insufficiency, Chronic
Chronic Kidney Diseases
Late Feasibility Study to Evaluate Safety and Efficacy of AWAK PD Device in Subjects With ESKD.
The goal of this late feasibility clinical trial is to evaluate the safety and effectiveness of the Automated Wearable Artificial Kidney (AWAK) peritoneal dialysis (PD) device in subjects with end-stage kidney disease.
- Trial name
- NCT05827588
- Testing
- AWAK PD
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- AWAK Technologies Pte Ltd
Chronic Kidney Disease, Diabetes
Effects of Febuxostat on Adipokines and Kidney Disease in Diabetic Chronic Kidney Disease
Hyperuricemia is emerging as a risk factor for development of diabetes and metabolic syndrome. Recently, it was shown in in-vitro cell culture experiments that hyperuricemia induces redox-dependent signaling and oxidative stress…
- Trial name
- NCT01350388
- Testing
- Febuxostat
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Chronic Kidney Diseases
Chronic Kidney Disease : Role of Biological Factors and Apolipoprotein L1 Encoding Gene (APOL1)
Chronic kidney disease (CKD) is a major global public health issue. The present project focuses on the role of apolipoprotein L1 (APOL1) in patients with stage 4 CKD (glomerular filtration rate between 15 and 29 mL/min/1.73 m²).
- Trial name
- APOL1 (NCT07288723)
- Where
- Guadeloupe
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Kidney Failure, Chronic
Evaluation of the Integrated Home Dialysis Model
The purpose of this study is to evaluate which home dialysis modality pattern (home hemodialysis [HHD], peritoneal dialysis [PD] or a combination of both, e.g.
- Trial name
- NCT02278159
- Testing
- Peritoneal dialysis, Home hemodialysis
- Volunteers
- 11,600 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Infections, Heart Failure
Rural Hospital-Level Care at Home for Acutely Ill Adults
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infections, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05256303
- Testing
- Home Hospital care, Traditional Hospital care
- Where
- 3 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Hypertension
Diuretics and Volume Overload in Early CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT05171686)
- Testing
- Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Sleep Apnoea, Renal Failure
The Effect of Haemodialysis in Sleep Apnoea
Sleep disturbance is a significant issue in people undergoing dialysis. More than 80% of haemodialysis patients complain of difficulty sleeping.
- Conditions
- Sleep Apnoea, Renal Failure, End Stage Kidney Disease, Sleep Disturbance
- Trial name
- NCT02939586
- Testing
- Haemodiafiltration post-dilution model, Haemodialysis
- Where
- 2 sites in Australia
- Volunteers
- 17 people
- Sponsor
- John Hunter Hospital
Kidney Disease
Zemplar® Capsule in Reducing Serum Intact Parathyroid Hormone Levels in Chronic Kidney Disease Stage 5 Subjects on Hemodialysis or Peritoneal Dialysis
The objective of this study is to determine the safety and efficacy of Zemplar® Capsule versus placebo, in decreasing elevated intact parathyroid hormone levels in chronic kidney disease stage 5 subjects with secondary…
- Trial name
- NCT00091975
- Testing
- Zemplar Capsule
- Where
- 16 sites in United States
- Volunteers
- 78 people
- Sponsor
- Abbott
Cognitive Impairment, Chronic Kidney Diseases
The Kidney and The Brain Study - Assessment of Cognitive Impairment in Advanced CKD
Patients with failed kidneys need Renal Replacement Therapy (RRT) to remove fluid and toxins from the body. The 3 types of RRT are kidney transplant or removal of waste by dialysis, either via the blood (haemodialysis) or via the…
- Conditions
- Cognitive Impairment, Chronic Kidney Diseases, End Stage Renal Disease, Dementia
- Trial name
- NCT03382444
- Testing
- Cognitive Assessment, Depression and Quality of Life Assessment
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Natalie Garratt
Renal Insufficiency
Evaluation of the Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Chronic Kidney Disease Without Exposure to Gadolinium Based Contrast Agents (GBCA)
The objective of this long term study is to prospectively evaluate the incidence of NSF in patients with severe CKD or kidney failure including patients undergoing dialysis (stages 4 and 5 i.e., with an eGFR below 30)who have not…
- Trial name
- NCT00773409
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Bracco Diagnostics, Inc
Chronic Kidney Disease
Efficacy and Safety of the Ultrasound Stimulation Device NEFRONIX in Patients With Chronic Kidney Disease
This study is a prospective, multicenter, single-arm, open-label, non-randomized exploratory clinical trial designed to evaluate the safety and potential efficacy of an ultrasound stimulation device (NEFRONIX G-01) in patients…
- Trial name
- NCT07339098
- Testing
- Ultrasound Stimulation (NEFRONIX G-01)
- Volunteers
- 20 people
- Sponsor
- Anasonic
Patient of Anemia in Chronic Renal Failure With Hemodialysis
A Phase 2 Clinical Study of Pegerythropoietin Injection (RD01) for the Treatment of Anemia in Chronic Renal Failure Patients With Hemodialysis
A multicenter randomized, single blind, active comparator controlled phase 2 study which is to evaluate the effectiveness, safety and the PK/PD characteristics of different doses, frequencies and routes of pegerythropoietin…
- Trial name
- NCT04231292
- Testing
- RD01, Recombinant Human Erythropoiesis Injection (CHO cell)
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Shengzhen Sciprogen Bio-pharmaceutical Co. Ltd
Systemic Lupus Erythematosus, Nephritis
The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria
Glomerulonephritis and renal failure represent one of the most life-threatening manifestations of systemic lupus erythematosus (SLE).
- Conditions
- Systemic Lupus Erythematosus, Nephritis, Proteinuria
- Trial name
- NCT00508898
- Testing
- Calcitriol, Multivitamin
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Disease, Chronic Renal Failure
Karolinska Cardiorenal Theme-centre and StockholmHeartbank
Chronic kidney disease (CKD) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death.
- Conditions
- Chronic Kidney Disease, Chronic Renal Failure, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- KKT (NCT01204645)
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Danderyd Hospital
End Stage Renal Disease, AV Fistula
Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD
A prospective single-arm well-controlled study to evaluate the safety and effectiveness of a less invasive means of establishing vascular access to facilitate dialysis in patients with end stage renal disease.
- Conditions
- End Stage Renal Disease, AV Fistula, Fistula, End Stage Kidney Disease
- Trial name
- NCT02363972
- Testing
- Ellipsys Vascular Access Catheter
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- Medtronic Endovascular
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
Improving Medication Safety for Kidney Disease With a Digital Drug Dosing Tool in Nova Scotia Community Pharmacy Practice.
Chronic kidney disease (CKD) is a common condition. It occurs in approximately 7 out of 100 Canadians and is highest in rural settings. The kidneys are responsible for the removal of many drugs from the body.
- Trial name
- NCT06820372
- Testing
- Electronic Drug Dosing and Decision Support Kidney (eDoseCKD) Tool
- Volunteers
- 125 people
- Sponsor
- Nova Scotia Health Authority
Chronic Kidney Diseases, Diabetes Mellitus
Chronic Kidney Disease and Cardiovascular Disease Risk Assessment
This study will investigate chronic kidney disease (CKD) and cardiovascular disease (CVD) risk factors in a sample population of Hispanics/Latinos and Caucasians in Yakima county that are rural dwelling.
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Hypertension
- Trial name
- NCT03975439
- Testing
- Hemoglobin A1C, Urinalysis, Whole blood creatinine level
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pacific Northwest University of Health Sciences
Type 2 Diabetes, Chronic Kidney Disease
Kidney Biopsy Indications in Type 2 Diabetes Patients
The WHO (World Health Organisation) estimated the prevalence of diabetes to be 422 million people in 2014, compared to 108 million in 1980.
- Trial name
- RIB-R2D2 (NCT04006028)
- Where
- 4 sites in France
- Volunteers
- 500 people
- Sponsor
- Rennes University Hospital
Chronic Kidney Disease
Evaluate the Efficacy and Safety of ABP-671 in Subjects With Chronic Kidney Disease and Hyperuricaemia
This is a phase 2, international, multicenter, randomized, double blind, placebo-controlled trial to evaluate the efficacy and safety of ABP-671 in subjects with CKD and hyperuricaemia, to preliminarily evaluate the efficacy of…
- Trial name
- NCT07323095
- Testing
- ABP-671 plus febuxostat Group 1, ABP-671 plus febuxostat Group 2, ABP-671 Group
- Where
- 10 sites in Australia, China
- Volunteers
- 80 people
- Sponsor
- Atom Therapeutics Co., Ltd
Chronic Kidney Disease
Niaoduqing Granules in Older Adults With Impaired Kidney Function
This prospective real-world study will evaluate the clinical benefits of Niaoduqing Granules in older adults with impaired kidney function.
- Trial name
- NCT07741292
- Testing
- Intervention Name
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
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