Clinical trials: Renal Insufficiency,Chronic
Heart Transplantation
Exchange of Azathioprine by Mycophenolatmofetile and Cyclosporine A Dose Reduction After Heart Transplantation
The purpose of this study is to improve or save renal function by optimizing the immunosuppressive regimen by reducing the Cyclosporine A dose and the exchange of Azathioprine by Mycophenolatmofetile, which is an effective…
- Trial name
- NCT00359814
- Testing
- Mycophenolatmofetile, Cyclosporin A
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Hannover Medical School
Chronic Kidney Diseases, Inflammation
Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition
Patients with chronic kidney disease, who have evidence of systemic inflammation with increased cardiovascular risk, will be enrolled into this trial.
- Trial name
- RESCUE (NCT03926117)
- Testing
- Ziltivekimab
- Where
- 49 sites in United States
- Volunteers
- 264 people
- Sponsor
- Novo Nordisk A/S
Kidney Diseases, Hemodialysis Complication
Hemodialysis Adequacy Using a Heparin-grafted Dialyzer and a Citrate-enriched Dialysate
After providing informed consent, patients will be randomized to either the intervention treatment ("EvoCit procedure") or the control treatment ("EvoHep procedure").
- Conditions
- Kidney Diseases, Hemodialysis Complication, End Stage Renal Disease
- Trial name
- EvoCit-HD (NCT03887468)
- Testing
- EvoCit, EvoHep
- Where
- 2 sites in Belgium
- Volunteers
- 38 people
- Sponsor
- Universitair Ziekenhuis Brussel
End Stage Renal Disease, Hypoalbuminemia
Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin
This study is to evaluate the impact of providing high protein supplementation in the form of a medical food bar containing 20grams of protein eath to hypoalbuminemic dialysis patients.
- Conditions
- End Stage Renal Disease, Hypoalbuminemia, Malnutrition
- Trial name
- NCT00597025
- Testing
- Protein Food Bar Intelligent Indulgence
- Where
- 2 sites in United States
- Volunteers
- 375 people
- Sponsor
- Satellite Healthcare
Chronic Kidney Diseases, Cystic Kidney Disease
Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension
The purpose of this research study is to evaluate contrast-enhanced ultrasound for kidney malignancies.
- Trial name
- CEUS-CKDx (NCT03196076)
- Testing
- Perflutren Lipid microsphere
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
End-Stage Renal Disease
Belatacept in Renal Transplantation With Intermediate Risk Maryland Aggregate Pathology Index (MAPI) Scores
This will be a pilot study to investigate the use of belatacept (BMS) therapy in kidney transplant patients who have a MAPI score of greater than or equal to 8.
- Trial name
- NCT01496417
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland
IgA Glomerulonephritis
Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)
This study will evaluate the long-term efficacy and safety of low dose oral methylprednisolone compared to matching placebo, on a background of routine RAS inhibitor therapy, in preventing kidney events in patients with IgA…
- Trial name
- TESTING (NCT01560052)
- Testing
- methylprednisolone
- Where
- 66 sites in Australia, Canada and 4 more
- Volunteers
- 503 people
- Sponsor
- The George Institute
Vitamin C, Oral Administration
Oral Vitamin C Administration on Erythropoietin Dosing Requirement in End-Stage Renal Disease Patients on Regular Hemodialysis
The study aimed to evaluate the safety and efficacy of oral vitamin C administration on erythropoietin dosing requirement in end-stage renal disease patients on regular hemodialysis.
- Conditions
- Vitamin C, Oral Administration, Erythropoietin, End-Stage Renal Disease
- Trial name
- NCT07076108
- Testing
- Normal regimen of treatment of anemia, Vitamin C
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
End-Stage Renal Disease
Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity
End-stage renal disease is often accompanied by malnutrition due to less appetite, metabolic changes or both. Human immunodeficiency virus-infection may exacerbate the state of malnutrition.
- Trial name
- NCT00687050
- Testing
- peroral high-caloric supplemental nutrition, peroral supplemental nutrition
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Chronic Rejection, Kidney Insufficiency
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients
The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA after renal transplant.
- Trial name
- NCT00261547
- Testing
- Rituximab
- Sponsor
- Massachusetts General Hospital
ESRD
Assessment of Gonadal Functions in Uremic Male Patients
1. Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) . 2. Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin…
- Trial name
- NCT04710238
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Kidney Disease
Supplemented Very Low Protein Diet and the Progression of Chronic Kidney Disease
This is a prospective single center randomized controlled trial with a total duration of 18 months aiming to evaluate the effectiveness and the safety of a very low protein diet supplemented with ketoanalogues of essential…
- Trial name
- KETOPROG (NCT02031224)
- Testing
- Conventional low protein diet, Very low protein diet supplemented with Ketosteril
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Anemia Working Group Romania
Chronic Kidney Disease Stage 3 and 4
Safety and Efficacy of Paricalcitol Capsules in Decreasing Serum Parathyroid Hormone Levels in Children Aged 10-16 With Chronic Kidney Disease (CKD)
Part 1: To determine the safety, tolerability, and pharmacokinetics of a single dose of 3 μg paricalcitol capsules in children ages 10 to 16 years with moderate to severe chronic kidney disease (CKD Stages 3 and 4).
- Trial name
- NCT01020487
- Testing
- Paricalcitol
- Volunteers
- 47 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Arterio-Venous Fistula, ESRD
VasQ External Support for Arteriovenous Fistula
This is a prospective clinical study of the VasQ external support for arteriovenous fistulas. The device is designed to improve fistula outcomes by optimizing the geometrical configuration of the fistula, influencing…
- Conditions
- Arterio-Venous Fistula, ESRD, Steal Syndrome, Aneurysm
- Trial name
- NCT03242343
- Testing
- VasQ
- Where
- 15 sites in United States
- Volunteers
- 144 people
- Sponsor
- Laminate Medical Technologies
Kidney Failure, Chronic
Dietary Maneuvers to Reduce Production of Colon-Derived Uremic Solutes
This study will assess whether dietary fiber supplements can reduce the production of chemicals which are produced by colon bacteria and normally excreted from the body by the kidney, but build up in the body in patients on…
- Trial name
- NCT01186276
- Testing
- Fiber, Corn starch
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- Stanford University
Kidney Function Decline, Chronic Kidney Disease
Comprehensive Kidney Function Assessment and Early Warning in Older Adults
This completed observational cohort study evaluates a comprehensive set of clinical and molecular markers of kidney function in two established cohorts of Chinese adults aged 60 years or older.
- Conditions
- Kidney Function Decline, Chronic Kidney Disease, Kidney Failure
- Trial name
- NCT07765134
- Where
- China
- Volunteers
- 5,588 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Renal Insufficiency, Chronic
Safety and Efficacy of Zemplar Capsule in Reducing Serum iPTH Levels in Chronic Kidney Disease Subjects (Daily Dosing)
The objective of this study is to determine whether paricalcitol is safe and effective compared to placebo in reducing elevated serum PTH levels in patients with chronic kidney disease.
- Trial name
- NCT00048516
- Testing
- paricalcitol capsule
- Where
- 18 sites in United States, Poland
- Volunteers
- 68 people
- Sponsor
- Abbott
Red-Cell Aplasia, Pure, Renal Insufficiency, Chronic
Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa
The purpose of this study is to determine occurrence of pure red cell aplasia in a group of participants with chronic renal insufficiency and with resistance criteria to epoetin alfa treatment.The investigational product is…
- Trial name
- NCT02648126
- Testing
- Pure Red Cell Aplasia diagnostic confirmation
- Volunteers
- 531 people
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Disorder Related to Renal Transplantation, Chronic Kidney Disease
Contribution of Renal Function to Endothelial Dysfunction in Living Kidney Donors and Transplant Recipients
Endothelial dysfunction one-year after transplantation mainly depends on transplant-associated factors and only marginally on reduced renal function.
- Conditions
- Disorder Related to Renal Transplantation, Chronic Kidney Disease, Endothelial Dysfunction
- Trial name
- CONFUCIUS (NCT02515643)
- Testing
- Endothelial dysfunction
- Where
- 4 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Sickle Cell Disease (SCD)
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease
The goal of the study was to evaluate descriptively the effect of crizanlizumab + standard of care and standard of care alone on renal function in sickle cell disease patients ≥ 16 years with chronic kidney disease due to sickle…
- Trial name
- STEADFAST (NCT04053764)
- Testing
- Crizanlizuamb, Standard of Care
- Where
- 24 sites in United States, Brazil and 9 more
- Volunteers
- 58 people
- Sponsor
- Novartis Pharmaceuticals
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