Clinical trials: Renal Replacement Therapies
Acute Kidney Injury Due to Sepsis (Disorder)
A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock
The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related organ failure assessment…
- Trial name
- NCT04073771
- Testing
- Continuous renal replacement therapy with oXiris
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Southeast University, China
Acute Kidney Injury
Frailty and Outcomes in Critically Ill Patients Receiving CRRT
This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden.
- Trial name
- CRRT-AF (NCT07837219)
- Volunteers
- 22,000 people
- Sponsor
- Karolinska Institutet
Kidney Diseases, Acute Injury of Kidney
Hemofilter Life Span, ECLS And/or CRRT
The goal of this project to better understand the immune-modulatory effects of continuous renal replacement therapy (CRRT) in neonatal and pediatric patients, particularly those receiving extracorporeal life support (ECLS).
- Conditions
- Kidney Diseases, Acute Injury of Kidney, Renal Failure, Renal Insufficiency
- Trial name
- NCT04193865
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Hemodialysis
HEMOTOL: Efficacy and Safety of Hemodialysis On-line Monitoring Devices on Hemodynamic Stability in Intensive Care Unit
The purpose of this randomized controlled study is to compare the effects of different new dialysis on-line monitoring devices on hemodynamic stability during intermittent hemodialysis in critically ill patients with acute kidney…
- Trial name
- HEMOTOL (NCT00811109)
- Testing
- Standard Hemodialysis, with Blood Volume Management (BVM®) only, with Blood Volume (BVM®) and Temperature (BTM®) on-line monitoring
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Renal Replacement Therapy
Blood Viscosity, End-Stage Renal Disease, And Mortality (BEAM-1)
Prospective, real-time observational study of hemodialysis patients treated with erythropoiesis-stimulating agents (ESA) to currently recommended Hgb targets.
- Trial name
- BEAM-1 (NCT01023893)
- Volunteers
- 400 people
- Sponsor
- ProMetrics, Inc.
Critical Ill Patients, Patients Needing Continuous Renal Replacement Therapy
Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients
CRRT patients are generally critical ill patients with unstable conditions, such as low blood pressure,severe SIRS,et al. Acute kidney injury(AKI)is especially prevalent,with even two or more organ failure.
- Trial name
- NCT02355873
- Testing
- AN69ST hemofilter, AN69 hemofilter
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Akut Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU
The Role of Renal Resistive Index (RI) in Predicting Acute Kidney Injury Progression in Intensive Care Clinic
Acute kidney injury(AKI) is defined in the KDIGO guidelines as a ≥0.3 mg/dL (≥26.5 micromol/L) increase in serum creatinine in the previous 48 hours or a ≥1.5-fold increase in serum creatinine from baseline, known or presumed to…
- Trial name
- NCT06995222
- Testing
- renal resistive index with Doppler ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Gulhane Training and Research Hospital
Acute Kidney Injury
Discontinuing CRRT in Patients with Acute Kidney Injury
In this study, investigators are going to test whether a standardize approach to discontinuation of Continuous Renal Replacement Therapy (CRRT) using a set of criteria improves outcomes.
- Trial name
- DC-CRRT (NCT04898595)
- Testing
- Discontinuation of CRRT
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- West Virginia University
Intensive Care Unit Syndrome
Ionized Magnesium for Monitoring of Citrate-anticoagulated CVVHD
It has been reported in several studies that ionized hypomagnesemia is associated with higher morbidity and mortality rates. During continuous renal replacement therapy with regional citrate anticoagulation (CRRT-RCA), the loss…
- Trial name
- MagiCC (NCT04412980)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Acute Kidney Injury, Chronic Kidney Diseases
Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration
To date, little knowledge exists related to the use of hemodialysis (HD) in infants and has been limited to mainly single center studies.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Renal Dialysis
- Trial name
- ICONIIC (NCT05161078)
- Testing
- CARPEDIEM
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sepsis Syndrome, MODS
Nafamostat Mesilate for Anticoagulation During CRRT in Critically Ill Patients
Continuous renal replacement therapy is widely used in intensive care medicine, which is known as an alternative therapy to save injured kidney . Anticoagulation is an important part of this therapy.
- Conditions
- Sepsis Syndrome, MODS, AKI, Hemorrhage
- Trial name
- NMFADCICIP (NCT05382078)
- Where
- China
- Volunteers
- 188 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Secondary Hypothyroidism
Thyroid Function in Critically Ill Patients With Acute Kidney Injury
The objective of this study was to assess the changes in thyroid hormones and its activity during CRRT in patients with Acute Kidney Injury.
- Trial name
- NCT04767763
- Testing
- Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Gdansk
Chronic Renal Anemia
A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)
This 2 arm safety study will compare the outcome with respect to a composite endpoint of all-cause mortality and non-fatal cardiovascular events (myocardial infarction, stroke) in CKD participants either on dialysis or not…
- Trial name
- NCT00773513
- Testing
- Darbepoetin Alfa, Epoetin Alfa, Epoetin Beta
- Where
- 196 sites in Argentina, Australia and 25 more
- Volunteers
- 2,825 people
- Sponsor
- Hoffmann-La Roche
Acute Renal Failure
Early Renal Replacement Therapy and the Outcome of Acute Kidney Injury
This research project is a prospective study to compare mortality between early renal replacement therapy (RRT) and late renal replacement therapy by using plasma neutrophil gelatinase associated lipocalin (pNGAL) as a tool in…
- Trial name
- EarlyRRT (NCT01819038)
- Testing
- continuous renal replacement therapy
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury
Citrate Versus Heparin Anticoagulation in Continuous Venovenous Hemofiltration
The purpose of this study is to compare citrate regional anticoagulation with systemic heparinization in continuous venovenous hemofiltration.
- Trial name
- CASH-CVVH (NCT00209378)
- Testing
- regional anticoagulation with citrate, HfCitPre
- Where
- 9 sites in Netherlands
- Volunteers
- 139 people
- Sponsor
- Universitair Ziekenhuis Brussel
Acute Renal Failure
Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis
Acute kidney injury is often treated with the use of continuous renal replacement therapy. Two commonly used treatments are continuous venvenous hemofiltration (CVVH)and continuous venovenous hemodialysis (CVVHD).
- Trial name
- NCT01062984
- Testing
- Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Chicago
Transgender, Renal Function
Renal Effects of Hormones/Biomarkers in Transgender PrEP Recipients
Will use a subset of the main study cohort of transgender or non-binary individuals to evaluate the relationships between self-reported exogenous hormone use, endogenous hormone values, renal biomarkers, drug levels and directly…
- Conditions
- Transgender, Renal Function, Hormone Replacement Therapy
- Trial name
- NCT04742816
- Testing
- IHX-CL measurements, Iohexol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Acute Kidney Injury
Early RRT in AKI After Cardiac Surgery
Acute kidney injury (AKI) is one of the major complications after cardiac surgery that may affects 20% to 40% of patients according to the definitions.
- Trial name
- NCT05175053
- Testing
- Renal replacement therapy, Best medical management
- Where
- 2 sites in South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury, Sepsis
Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™.
- Trial name
- NCT06253377
- Testing
- Adsorption membrane filter Oxiris™
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nefro Consultoria de Doenças Renais Ltda