Clinical trials: Renal Replacement Therapies
Acute Kidney Injury
Continuous Central Venous Oxygen Saturation Measurement as a Tool to Predict Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Acute kidney injury (AKI) is common in intensive care unit (ICU) and inducing a high morbidity and mortality. In severe forms of AKI (more than 25% of AKI patients admitted to the ICU), renal replacement therapy (RRT) is often…
- Trial name
- SoVHIRR (NCT05897840)
- Testing
- Fiber-optic probe CeVOX
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Chronic Kidney Disease
Impact of Specialised Renal Care in Patients With Chronic Kidney Disease
This is a prospective randomised trial studying patients with stage 3 to 5 chronic kidney disease (CKD) in order to determine the impact of specialised care by nephrologists compared to guidelines-directed management by primary…
- Trial name
- IMPLICATE (NCT00929760)
- Testing
- specialised renal care
- Where
- Switzerland
- Volunteers
- 242 people
- Sponsor
- Patrick Saudan
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
End-stage Renal Disease, Renal Replacement Therapy
Can High Convection Volumes be Achieved in Each Patient During Online Post-dilution Hemodiafiltration?
Two recent randomized controlled trials (RCT) on online hemodiafiltration (HDF) did not show a treatment effect on patient survival when compared with low- or high-flux hemodialysis.
- Conditions
- End-stage Renal Disease, Renal Replacement Therapy, Hemodiafiltration, Convection Volume
- Trial name
- NCT01877499
- Testing
- Optimization of HDF key parameters
- Where
- 7 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Amsterdam UMC, location VUmc
End Stage Renal Failure
Physical and Psychological Profiles Associated With Patient's Preference for ESRD Treatment
Highlighting the relationship between psychological and physical profiles and patient's preference to better understand the patient's treatment preference and improve the information provided.
- Trial name
- NCT01834755
- Testing
- Evaluation of psychological phenotype
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Critical Illness, COVID-19 Pneumonia
Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
The aim of this study is to evaluate the rate and outcomes of COVID-19 associated acute kidney injury (AKI) and use of kidney replacement therapy (KRT) in critically ill COVID-19 patients in ICUs in several large hospitals in…
- Conditions
- Critical Illness, COVID-19 Pneumonia, Acute Kidney Injury
- Trial name
- COVID-AKI-B (NCT04997915)
- Testing
- Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
- Where
- 9 sites in Belgium
- Volunteers
- 1,286 people
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury, End Stage Chronic Renal Failure
Feasibility of Intradialytic Monitoring During CKRT
This is a pilot observational cohort study to understand whether advanced monitoring techniques can be applied during continuous kidney replacement therapy (CKRT), which is the most common form of dialytic therapy provided in…
- Conditions
- Acute Kidney Injury, End Stage Chronic Renal Failure, Dialysis
- Trial name
- NCT07428395
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Acute Kidney Injury
Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKI
This observational study aims to explore the factors that influence the risk of new infections in critically ill patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) in the UK.
- Trial name
- CRRTinfUK (NCT07903519)
- Where
- United Kingdom
- Volunteers
- 630 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Acute Kidney Injury
Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
- Trial name
- NCT06091982
- Testing
- Renal Replacement Therapy (RRT)
- Where
- Indonesia
- Volunteers
- 1,113 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Acute Kidney Injury, Renal Replacement Therapy
Effects of Variation of Sodium Dialysate in ICU
Intermittent hemodialysis/diafiltration is a current renal replacement therapy (RRT) institued for ICU patients with AKI. For a better clinical tolerance, iinternational guidelines advise to use cold dialysate, increase duration…
- Trial name
- NADIRA (NCT03329313)
- Testing
- Lowering sodium concentration dialysate, Highing sodium concentration dialysate
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Vitamin D3 Deficiency
Vitamin D3 Supplementation in Critically Ill Patients Undergoing CRRT
Patients hospitalized in intensive care units (ICU) are particularly susceptible to vitamin D3 deficiencies. This can be due to the severity of their underlying disease, the type of treatment they are on, malnutrition before and…
- Trial name
- NephroD (NCT05657678)
- Testing
- Vitamin D3 - 750 000 IU, Vitamin D3 - 500 000 IU
- Where
- 4 sites in Poland
- Volunteers
- 138 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Acute Renal Failure, Hemorrhage
Impact of Renal Replacement Therapy on Coagulation Profile of Patients with Acute Renal Failure
Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters.
- Conditions
- Acute Renal Failure, Hemorrhage, Coagulation Disorder
- Trial name
- HEMOSTIR (NCT03536195)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Brest
Obstructive Sleep Apnea, End Stage Renal Disease
Effect of Beginning a Renal Replacement Therapy on Obstructive Sleep Apnea in End Stage Renal Disease Patients
The purpose of this study is to investigate the effect of beginning a renal replacement therapy on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Trial name
- SASinHD_005 (NCT02073344)
- Testing
- Renal replacement therapy, no intervention
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Injury
Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows…
- Trial name
- NCT02595619
- Testing
- RRT plus ECCO2R
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Turin, Italy
Hypoxic-Ischemic Encephalopathy, Sepsis
Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Sepsis, Kidney Diseases, Metabolic Disease
- Trial name
- NCT05495607
- Testing
- CARPEDIEN
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Renal Failure
Acute Renal Failure Trial Network (ATN) Study
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in…
- Trial name
- ATN (NCT00076219)
- Testing
- renal replacement therapy
- Where
- 22 sites in United States
- Volunteers
- 1,124 people
- Sponsor
- US Department of Veterans Affairs
Acute Kidney Injury
Retrospective Observational Study of Cotrimoxazole Dosing in Intensive Care Unit
Trimethoprim/sulfamethoxazole (TMP/SMX, cotrimoxazole) is the first-line therapy for Pneumocystis jirovecii pneumonia and bacterial infections in critically ill patients, where acute kidney injury (AKI) and renal replacement…
- Trial name
- NCT05221216
- Testing
- Collect data of medical record
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Renal Injury, Regional Citrate Anticoagulation
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid.
- Conditions
- Renal Injury, Regional Citrate Anticoagulation, Continuous Renal Replacement Therapy
- Trial name
- NCT06021080
- Testing
- CVVH, CVVHD
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fujian Provincial Hospital
AKI - Acute Kidney Injury, Acute Renal Failure
A Post-Market Clinical Performance and Safety Evaluation of GamCath HighFlow Dolphin Protect Catheter
The goal of this retrospective chart review is to obtain clinical safety and performance data for the GamCath HighFlow Dolphin Protect Catheter in patients with acute kidney injury, acute renal failure, or chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Acute Renal Failure, CKD, ESRD
- Trial name
- NCT05888376
- Testing
- Vascular access catheter to support dialysis or CRRT
- Where
- 2 sites in Poland
- Volunteers
- 76 people
- Sponsor
- Vantive Health LLC