Clinical trials: Renal Stone Disease
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Urolithiasis, Stones, Kidney
Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology
The goal of this clinical trial is to compare Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System and standard ureteroscopy (URS) with laser lithotripsy for the treatment of urolithiasis.
- Conditions
- Urolithiasis, Stones, Kidney, Renal Stones, Kidney Stones
- Trial name
- TRUST (NCT07101809)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System, Standard Ureteroscopy (URS)
- Where
- 6 sites in United States
- Volunteers
- 150 people
- Sponsor
- Calyxo, Inc.
Kidney Stones, Urolithiasis
DISON I - Directly Integrated Suction and Optics System for the Treatment of Nephrolithiasis
A single-arm, multicenter, international, prospective interventional study designed to evaluate the safety and performance of an investigational device during retrograde intrarenal surgery for the treatment of renal calculi.
- Conditions
- Kidney Stones, Urolithiasis, Nephrolithiasis
- Trial name
- DISON I (NCT07712861)
- Testing
- RIRS with Investigational Device
- Where
- 5 sites in Argentina, Canada and 3 more
- Volunteers
- 75 people
- Sponsor
- Ventaris Surgical Incorporated
Kidney Stones, Urolithiasis
PMCF Investigation of MODULITH® SLX-F2 With StorM-Track in Patients With Kidney Stones
Extracorporeal shockwave lithotripsy (ESWL) is a non-invasive standard treatment for kidney stones. This study will be conducted to evaluate the effectiveness of ESWL using MODULITH® SLX-F2 with stone tracking, compared to…
- Trial name
- NCT07272720
- Testing
- ESWL with kidney stone tracking (StorM-Track), Standard ESWL without stone tracking (StorM-Track disabled)
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Storz Medical AG
Renal Calculi, Kidney Stones
Clinical Evaluation of BackStop in Patients Undergoing Intraureteric Stone Lithotripsy
The purpose of this clinical study is to evaluate BackStop, a polymer-based device that is intended to be used during ureteroscopic lithotripsy to prevent retrograde stone migration.
- Trial name
- NCT00893282
- Testing
- BackStop, Intracorporeal lithotripsy without the use of an anti-retropulsion device
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Pluromed, Inc.
Urolithiasis
Efficacy of Neorenal Forte for the Complete Elimination of Residual Fragments
The purpose of this study is to evaluate the efficacy of a specialized formula of phytotherapeutic extracts (Neorenal Forte) aiding the complete elimination of residual fragments after fURS in adults.
- Trial name
- NERFA (NCT06651294)
- Testing
- Neorenal Forte
- Where
- 7 sites in Bulgaria
- Volunteers
- 93 people
- Sponsor
- Neopharm Bulgaria Ltd.
Prostatic Hyperplasia, Kidney Calculi
Aqueduct Irrigation System Clinical Protocol: Medical Device Investigational Plan
A. Synopsis 1. This protocol comes to direct the experiment to be performed on the Aqueduct Automatic Continuous Irrigation system. 2.
- Conditions
- Prostatic Hyperplasia, Kidney Calculi, Bladder Tumors
- Trial name
- NCT02496442
- Testing
- Aqueduct
- Volunteers
- 30 people
- Sponsor
- Flowmed
Kidney Stone, Urolithiasis
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
The goal of this clinical trial is to test the Break Wave™ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones.
- Conditions
- Kidney Stone, Urolithiasis, Nephrolithiasis, Renal Calculi
- Trial name
- SOUND (NCT05701098)
- Testing
- Break Wave extracorporeal lithotripsy
- Where
- 10 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- SonoMotion
Prostate Cancer, Kidney Cancer
DS Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)
Prospective, monocentric, single arm, observational PMCF - Study on the Performance and Safety of Double-Shank Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)
- Conditions
- Prostate Cancer, Kidney Cancer, Congenital Abnormality of Kidney, Nephrolithiasis
- Trial name
- DOSTILCU (NCT04869462)
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Aesculap AG
Healthy Volunteers, Enteric Hyperoxaluria
Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects
The first stage of this study is a prospective, adaptive, Phase 1, first-in-human, randomized, controlled study evaluating safety, tolerability, and pharmacodynamics of NOV-001 in adult healthy volunteers.
- Trial name
- NCT04909723
- Testing
- NOV-001, NB1000S, NB2000P
- Where
- 20 sites in United States, Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Novome Biotechnologies Inc
Soft Tissue Injuries, Gouty Arthritis
AMPED Outcomes Registry of Post-ED Pain Management
Study aims to assess patient-recorded outcomes of pain control medications prescribed in the ER after visits for specific painful injuries/illnesses.
- Conditions
- Soft Tissue Injuries, Gouty Arthritis, Fractures, Ureteral Colic
- Trial name
- AMPED (NCT01626235)
- Where
- 11 sites in United States
- Volunteers
- 843 people
- Sponsor
- Radnor Registry Research, Inc
Renal Colic, Urinary Calculi
Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management
Abdominal pain is one of the most common presentations to an emergency department (ED). Among patients presenting with abdominal pain, a common diagnosis in the Middle East is renal colic (urolithiasis or Kidney stones).
- Trial name
- NCT02187614
- Testing
- Diclofenac, Morphine, Paracetamol
- Where
- Qatar
- Volunteers
- 1,645 people
- Sponsor
- Hamad Medical Corporation
Ureteral Calculi, Kidney Stones
Study of Silodosin to Facilitate Passage of Urinary Stones
The purpose of this study is to assess if patients treated with silodosin will have a higher spontaneous passage rate of their ureteral stone than those treated with placebo.
- Conditions
- Ureteral Calculi, Kidney Stones, Urolithiasis
- Trial name
- NCT01144949
- Testing
- silodosin
- Where
- 27 sites in United States
- Volunteers
- 239 people
- Sponsor
- Watson Pharmaceuticals
Kidney Calculi
Stone Access and Removal (STAR) Study
The purpose of the study is to assess procedural completion, the post-operative stone clearance and the safety profile following robotic mini-Percutaneous Nephrolithotomy (PCNL) performed with the MONARCH Platform, Urology.
- Trial name
- STAR (NCT06330701)
- Testing
- Robotic-assisted mini-PCNL
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Benign Prostate Hypertrophy(BPH), Renal Calculi
Stone and Laser Therapies Post-Market Study (SALT)
The objective of the SALT Study is to obtain post-market safety and device performance data for Boston Scientific's Stone and BPH study devices used during a diagnostic and/or therapeutic urinary tract procedure (e.g.…
- Conditions
- Benign Prostate Hypertrophy(BPH), Renal Calculi, Ureteral Stones, Kidney Stones, Calculi, Urinary
- Trial name
- SALT (NCT06982235)
- Testing
- Ureteroscope system, Laser system
- Where
- 5 sites in United States
- Volunteers
- 238 people
- Sponsor
- Boston Scientific Corporation
Primary Hyperoxaluria Type 1
A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)
A phase 1 study of DCR-PH1 in patients with primary hyperoxaluria type 1 (PH1) to determine the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics (PD) effects of DCR-PH1 administered via-intravenous infusion (IV)
- Trial name
- NCT02795325
- Testing
- DCR-PH1
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 41 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Enteric Hyperoxaluria
Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH).
A Phase II, Multi-center, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of TRA16 Administered Orally in Patients with Enteric Hyperoxaluria (EH).
- Trial name
- NCT07871669
- Testing
- TRA16
- Volunteers
- 30 people
- Sponsor
- Wuhan Kangfude Urolithiasis Research Institute Co., Ltd.
Kidney Stones
A Phase 2a Study of LLX-424 in Patients With a History of Kidney Stones
This is a Phase 2a study of glycolate oxidase inhibitor LLX-424 in patients with a history of kidney stones. Eligible subjects with a history of kidney stones will be randomized to receive study drug (LLX-424 or placebo) for 8…
- Trial name
- NCT06932146
- Testing
- LLX-424
- Where
- 3 sites in United States
- Volunteers
- 51 people
- Sponsor
- Lilac Therapeutics, Inc.
Secondary Hyperoxaluria, Nephrolithiasis
Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days
Evaluate the safety, tolerability, and efficacy of 28 days of treatment with ALLN-177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and kidney stones.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Hyperoxaluria, Kidney Stones
- Trial name
- NCT02547805
- Testing
- ALLN-177
- Where
- 22 sites in United States
- Volunteers
- 66 people
- Sponsor
- Allena Pharmaceuticals
Kidney Calculi
Initial Clinical Experience With the MONARCH Platform, Urology for the Treatment of Kidney Stones
The purpose of this study is to collect descriptive performance data using the MONARCH Platform, Urology (a novel robotic device) to perform mini-percutaneous nephrolithotomy (kidney stone removal) procedures.
- Trial name
- NCT05835323
- Testing
- Robotic-assisted mini-PCNL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.