Clinical trials: Renal Stone Disease
Kidney Stone
Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous…
- Trial name
- FIREStones (NCT05916963)
- Testing
- Furosemide 40 mg
- Where
- 9 sites in France
- Volunteers
- 374 people
- Sponsor
- University Hospital, Tours
Nephrolithiasis
Narcotic-Free Percutaneous Nephrolithotomy
This is a randomized control trial comparing oral ketorolac and opioid medication for the use of post-operative analgesia.
- Trial name
- NCT05924165
- Testing
- 5mg Oxycodone, Q6 PRN, 10mg Ketorolac, Q6 PRN
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Renal Stone, Pediatric
Flexible Ureteroscopy Versus Mini- Percutaneous Nephrolithotomy in Management of Pediatric Renal Stones Less Than 2 cm
This single-center, prospective, two-arm randomized controlled trial included 58 patients younger than 18 years who were allocated 1:1 to Mini-PCNL or FURS between June 2023 and December 2024.
- Trial name
- NCT07870200
- Testing
- Group A :Flexible ureteroscope group, Group B : Mini perc group
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elsayed Abdelhalim Elsayed
Oral Dissolution Therapy, Extracorporeal Shock Wave Lithotripsy
The Efficacy of Oral Dissolution Therapy (ODT), Extracorporeal Shock Wave Lithotripsy (ESWL), and Combined ESWL and ODT as Non-Invasive Modalities for Treating Small and Medium-Sized Radiolucent Renal Stones
This study aimed to compare oral dissolution therapy (ODT), extracorporeal shock wave lithotripsy (ESWL), and a combination of ESWL and ODT as noninvasive modalities for treating small and medium-sized renal radiolucent.
- Conditions
- Oral Dissolution Therapy, Extracorporeal Shock Wave Lithotripsy, Noninvasive, Small
- Trial name
- NCT06814834
- Testing
- Oral dissolution therapy, Extracorporeal shock wave lithotripsy, Oral dissolution therapy + extracorporeal shock wave lithotripsy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Kidney Stones
Laser Versus Ultrasonic Lithotripsy in Percutaneous Nephrolithotomy for Staghorn Stones
This study will be conducted to compare the results of Laser and ultrasonic lithotripsy in disintegration of staghorn stones during percutaneous nephrolithotomy.
- Trial name
- NCT01922414
- Testing
- Laser, Ultrasonic
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Analgesia, Postoperative Pain Management
ESP Block for Postoperative Analgesia in URS Surgery
The goal of this clinical trial is to determine whether the erector spinae plane (ESP) block provides better pain relief after flexible ureterorenoscopy (URS) surgery compared to standard analgesia alone.
- Conditions
- Analgesia, Postoperative Pain Management, Nephrolithiasis
- Trial name
- ESPURS (NCT06826833)
- Testing
- Erector Spinae Plane (ESP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Namik Kemal University
Urologic Diseases, Urolithiasis
Medical Expulsive Therapy Post-SWL For Renal Stones
To evaluate the efficacy and stone free rate of placebo versus tamsulosin as medical expulsive therapy post-SWL in patients with renal stone less than 20 mm
- Conditions
- Urologic Diseases, Urolithiasis, Stone, Kidney
- Trial name
- NCT05032287
- Testing
- Tamsulosin
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Mansoura University
Kidney Stone
Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence
In clinical practice, many patients are not able to modify their habits to achieve a high level of diuresis and fluid intake and therefore are at an elevated risk for stone recurrence.
- Trial name
- Ure-Na (NCT04727606)
- Testing
- Ure-Na
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Kidney Stone, Nephrolithiasis
Pediatric KIDney Stone (PKIDS) Care Improvement Network
The goals of this study are to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones and to enable urologists to use techniques that result in the best outcomes for…
- Trial name
- PKIDS (NCT04285658)
- Testing
- Ureteroscopy, Percutaneous Nephrolithotomy, Shock Wave Lithotripsy
- Where
- 31 sites in United States, Canada
- Volunteers
- 1,290 people
- Sponsor
- Children's Hospital of Philadelphia
Prostate Cancer, Benign Prostatic Hypertrophy
Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones.
This is a double-blind, study to evaluate the performance of NV-VPAC1 PCa Urine Diagnostic Test in three distinct populations being treated at the Intermountain Urology Clinic.
- Conditions
- Prostate Cancer, Benign Prostatic Hypertrophy, Bladder Stones, Kidney Stones
- Trial name
- VPAC (NCT03630926)
- Testing
- NV-VPAC1 PCa Urine Diagnostic Test
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Intermountain Health Care, Inc.
Nephrolithiasis, Nephrocalcinosis
Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels
Hypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis leading to Chronic Kidney Disease (CKD) and bone complications in adults.
- Conditions
- Nephrolithiasis, Nephrocalcinosis, Hypercalciuria
- Trial name
- FLUCOLITH (NCT04495608)
- Testing
- Fluconazole
- Where
- 11 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Urolithiasis, UTI
Antibiotic Prophylaxis With Routine Ureteral Stent Removal
This study will be a single-institutional randomized, single-blinded prospectively controlled clinical trial of a single dose of Ciprofloxicin 500mg antibiotic tablet as prophylaxis at the time of office flexible cystoscopy with…
- Trial name
- STENTABX (NCT02944825)
- Testing
- Ciprofloxacin, trimethoprim/sulfamethoxazole, No Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Nephrolithiasis, Calcium Oxalate Kidney Stones
Vitamin E Supplementation Effect in Management of Calcium Oxalate Crystals
Nephrolithiasis is a condition characterized by the formation of crystalline stones in the urinary system. The most common component of these stones is calcium oxalate.
- Trial name
- NCT07715643
- Testing
- Control Group T0, Intervention Group T1, Intervention Group T2
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Lahore
Stone, Kidney, Stone Ureter
Virtual Reality for Pain Control During Extracorporeal Shock Wave Lithotripsy: a Prospective, Comparative, Randomized Study at a Single Institution
The aim of this study is to prospectively analyze patient satisfaction, pain, delivered energy and clinical effectiveness of using VR as a complimentary treatment modality during SWL.
- Trial name
- NCT05183269
- Testing
- Oncomfort virtual reality monitor (Oncomfort SA, Wavre, Belgium)
- Where
- Belgium
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- AZ Sint-Lucas Gent
Secondary Hyperoxaluria, Nephrolithiasis
Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days
Evaluate the safety, tolerability, and efficacy of 28 days of treatment with ALLN-177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and kidney stones.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Hyperoxaluria, Kidney Stones
- Trial name
- NCT02547805
- Testing
- ALLN-177
- Where
- 22 sites in United States
- Volunteers
- 66 people
- Sponsor
- Allena Pharmaceuticals
Kidney Stone
Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers
The primary goals of this study are to determine the contribution of dietary oxalate absorption, renal oxalate handling, and endogenous oxalate synthesis to urinary oxalate excretion in normal Body Mass Index (BMI) and obese…
- Trial name
- NCT04333745
- Testing
- Controlled Diet, Carbon-13 Oxalate and Sucralose Ingestion
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Renal Calculi (Kidney Stones) ≤ 20 mm
Super-Mini Percutaneous Nephrolithotomy Versus Flexible Ureteroscopy for Renal Stones 20 mm or Less
Kidney stones measuring 20 mm or less are commonly managed using minimally invasive surgical techniques. Two widely used approaches are Super-mini Percutaneous Nephrolithotomy (SMP) and Flexible Ureteroscopy (fURS).
- Trial name
- NCT07371494
- Testing
- Super-mini Percutaneous Nephrolithotomy, Flexible Ureteroscopy
- Where
- Vietnam
- Volunteers
- 72 people
- Sponsor
- Hanoi Medical University
Stones, Kidney
Optimal Drainage After Flexible Ureterorenoscopy; Prospective Assessment of Perioperative Outcomes and Health-Related Quality of Life Through a Randomized Controlled Trial
Flexible ureterorenoscopy (FURS) is now recommended for the treatment of kidney stones smaller than 20 mm, as an alternative to extracorporeal shock wave lithotripsy (ESWL) and in combination with percutanous nephrolithotomy…
- Trial name
- NCT04643145
- Testing
- Flexible ureteroscopy for renal calculi less than 20 mm
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Mansoura University
Renal Stones, Flexible Ureteroscopy
Criteria for DJ Stent Omission Following Retrograde Intrarenal Surgery Using Flexible and Navigable Suction Sheath: A Prospective Cohort Study
Retrograde intrarenal surgery is widely used for the treatment of upper urinary tract stones. Traditionally, ureteral stents are placed postoperatively to prevent complications such as pain and stone obstruction.
- Trial name
- NCT07826169
- Testing
- flexible ureteroscopy using flexible and navigable suction sheath
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Nephrolithiasis, Ureteral Calculi
The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
The purpose of this study is to determine the efficacy of the α-adrenergic antagonist tamsulosin in the treatment of adult emergency department (ED) patients with ureteral colic secondary to lower ureteral calculus.
- Trial name
- NCT00600405
- Testing
- tamsulosin, Standard therapy with ibuprofen and oxycodone.
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- MaineHealth