Clinical trials: Renal Stone Disease
Kidney Calculi, Urolithiasis
Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS
Retrograde intrarenal surgery (RIRS) is a widely used treatment for kidney stones; however, postoperative infectious complications remain a significant concern.
- Conditions
- Kidney Calculi, Urolithiasis, Urinary Tract Infections
- Trial name
- NCT07655050
- Testing
- Standard Retrograde Intrarenal Surgery, Gentamicin Irrigation, Suction-Enabled Ureteral Access Sheath
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Hitit University
Primary Hyperoxaluria Type 3
Natural History of Patients With PH3 and a History of Stone Events
This is a natural history study of adults, adolescents, and children (starting at birth) with genetically confirmed primary hyperoxaluria type 3 (PH3) who have a history of stone events during the last 3 years and/or the presence…
- Trial name
- PHYOX-OBX (NCT04542590)
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 7 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Hypercalciuria; Idiopathic, Nephrolithiasis
Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria
The investigator's objective is to compare and evaluate the impact of nutritional treatment vs. pharmacological treatment (hydrochlorothiazide) in bone mineral density in children with idiopathic hypercalciuria.
- Trial name
- HIC (NCT03951558)
- Testing
- Diet for calciuria prevention, Hydrochlorothiazide
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Nephrolithiasis
Efficacy and Safety of Using MPC-5971 in Subjects Undergoing Shock Wave Lithotripsy
The purpose of this study is to evaluate the efficacy of MP-5971 in facilitating stone passage after Shock Wave Lithotripsy treatment.
- Trial name
- NCT00860093
- Testing
- MPC-5971
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- Mission Pharmacal
Kidney Stones
Stone Centre Urine and Serum Bank
Purpose: The purpose of the Stone Centre Serum and Urine Bank is to provide researchers with large numbers of serum and urine samples from kidney stone patients and controls for study of stone disease detection and treatment, and…
- Trial name
- NCT00759343
- Where
- 2 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Kidney Stones, Urolithiasis
ILY Robotic System vs Manual Flexible Ureteroscopy for Kidney Stone Treatment
The goal of this clinical trial is to compare the efficacy, ergonomics, and safety of robotic versus manual flexible ureteroscopy (fURS) for kidney stone treatment in adult patients undergoing laser lithotripsy.
- Trial name
- iFURS (NCT06996587)
- Testing
- Robotic-Assisted Flexible Ureteroscopy, Manual Flexible Ureteroscopy
- Where
- Lebanon
- Volunteers
- 152 people
- Sponsor
- Albert El Hajj
Kidney Stones
Effect of Sodium Thiosulfate on Urine Chemistries of Hypercalciuric Stone Formers
Sodium thiosulfate may be useful to prevent recurrence of calcium-containing kidney stones. It will be studied in people with high amounts of urine calcium.
- Trial name
- NCT01088555
- Testing
- Sodium thiosulfate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA New York Harbor Healthcare System
Renal Stones, Renal Calculi > 2 cm
Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones
The investigator will compare between holmium laser setting during miniPCNL for renal stones as regard safety \& efficacy
- Trial name
- miniPCNL (NCT07393178)
- Testing
- mini percutaneous nephrolithotomy
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Kidney Calculi
Ureteroscopy Combined With Negative Pressure Sheath Treatment of Kidney Stones
The removal rate, complication risk and operation time of ureteral soft scope combined with negative pressure suction sheath therapy for patients with high-load kidney stones (2-3cm) are still controversial.
- Trial name
- NCT06938113
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Peking University First Hospital
Urolithiasis, Kidney Stone
Standard vs Mini-PCNL for the Treatment of Stone Disease
Randomized comparison of patient outcomes following standard PCNL versus mini-PCNL.
- Conditions
- Urolithiasis, Kidney Stone, Kidney Calculi, Ureteral Calculi
- Trial name
- NCT04069013
- Testing
- PCNL
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The Cleveland Clinic
Renal Colic
Pramipexole and Morphine for Renal Colic
Opioid analgesics are among the most commonly prescribed class of medications in the US. While opioids may effectively control pain and other sensory disorders under acute conditions, the rates of misuse/abuse and accidental…
- Trial name
- NCT04160520
- Testing
- Pramipexole, Morphine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- East Carolina University
Renal Stone
Erector Spinae Plane Block for Analgesia During ESWL
this study aims to compare between efficacy of erector spinae plane block and conventional multimodal analgesia in Extracorporeal shock wave lithotripsy
- Trial name
- NCT07067996
- Testing
- erector spinae plane block, Nalbuphine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Renal Stones, Kidney Stone
CLinical Evaluation of Aspiration for Removal ANd ClearancE of Stones
The purpose of the study is to assess safety and efficacy of a novel steerable ureteral catheter system, the CVAC System for the treatment of urinary stones.
- Conditions
- Renal Stones, Kidney Stone, Urolithiasis
- Trial name
- CLEARANCE (NCT06615713)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Calyxo, Inc.
Urolithiasis, Kidney Stone
Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
Background: Percutaneous nephrolithotomy (PCNL) is the first-line treatment for renal stones larger than 2 cm according to EAU and AUA guidelines.
- Trial name
- NCT06526390
- Testing
- f-URS, mini-PCNL
- Where
- China
- Volunteers
- 720 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Enteric Hyperoxaluria
Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria
The purpose of this study is to determine the efficacy, durability and long-term safety of reloxaliase in patients with enteric hyperoxaluria.
- Trial name
- URIROX-2 (NCT03847090)
- Testing
- Reloxaliase
- Where
- 113 sites in United States, Austria and 14 more
- Volunteers
- 92 people
- Sponsor
- Allena Pharmaceuticals
Nephrolithiasis
Mature Vinegar Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis
Kidney stones are one of the most common disorders of the urinary tract and cause a great deal of morbidity and economic loss. Because of the high recurrence rate, researchers are interested in finding medicinal therapies to…
- Trial name
- NCT03092908
- Testing
- mature vinegar
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Kidney Stones, Ureteral Stones
The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
To determine if emergency department patients with acute ureteral colic pain due to a ureteral stone who are treated with tamsulosin, versus placebo, will experience a shorter time to passage of their stone or resolution of their…
- Trial name
- NCT00448123
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Robert Swor
Urolithiasis
Effect of Ureteral Access Sheath Use on Postoperative Pain Level in Patients Undergoing RIRS
This study will include patients aged between 18 and 70 who will undergo retrograde intrarenal surgery (RIRS) due to renal stone(s).
- Trial name
- NCT02501525
- Testing
- RIRS with ureteral access sheath, RIRS without ureteral access sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Nephrolithiasis, Kidney Stone
Observational Approach Versus Surgical Intervention for Stones
The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to upfront surgery results in less healthcare-related life disruption due…
- Trial name
- OASIS (NCT07718802)
- Testing
- Surgery, Observation
- Where
- 4 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Children's Hospital of Philadelphia
Nephrolithiasis
Effect of Antihistamines on Ureteral Stent-Related Symptoms
This is a prospective, double-blind, randomized, open-label, single-center trial of up to 78 participants who are adult patients (aged 18-80 years) and are undergoing unilateral retrograde ureteroscopy with planned ureteral stent…
- Trial name
- NCT04726345
- Testing
- Fexofenadine Hcl 180Mg Tab
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Columbia University