Clinical trials: Renal Stone Disease
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
Urolithiasis, Kidney Stones
Pain Control During ESWL Using Non-Opioid Analgesics
This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL).
- Conditions
- Urolithiasis, Kidney Stones, Ureteral Stones
- Trial name
- ESWL-PAIN (NCT07512297)
- Testing
- Ibuprofen (Brufen®), Paracetamol (drug), Tenoxicam
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- University of Gaziantep
Kidney Stone
Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care
Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration.
- Trial name
- NCT06367894
- Where
- Belgium
- Volunteers
- 164 people
- Sponsor
- Agnieszka Pozdzik
Urolithiasis
sipIT2: Improving Adherence to Fluid Intake Guidelines for Kidney Stone Prevention
The purpose of this study is to examine the feasibility of using sipIT tools (i.e., wrist-worn sensors, smart water bottles, mobile applications) to increase compliance with physician-recommended fluid consumption guidelines in…
- Trial name
- NCT05196113
- Testing
- sipIT
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Urolithiasis, Stone, Kidney
Registry of MIUS for Urolithiasis (ReMIUS-U)
The purpose of this registry is to collect data on patients who have undergone minimally invasive treatments for urinary system stone disease, including percutaneous nephrolithotomy (PCNL), shock wave lithotripsy (SWL)…
- Conditions
- Urolithiasis, Stone, Kidney, Stone Ureter, Complication of Surgical Procedure
- Trial name
- ReMIUS-U (NCT06394908)
- Where
- Turkey (Türkiye)
- Volunteers
- 10,000 people
- Sponsor
- Marmara University
Stone, Kidney
Evaluation of Retrograde Intra Renal Surgery in the T-tilted Position
To evaluate the effect of the T-tilted position on the stone-free rate compared to the standard lithotomy position in retrograde intrarenal surgeries.
- Trial name
- RIRS (NCT06860113)
- Testing
- T-tilting of the patient during surgery, standard lithotomy position
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Calculi, Urinary Tract Infections
Is it Necessary for Patients With a Positive Urine Culture to Achieve a Negative Result After Antimicrobial Treatment Before Undergoing Percutaneous Nephrolithotomy?
Objective: The current European Association of Urology (EAU) guidelines do not provide clear recommendations on whether patients with a positive urine culture(UC) should wait until the culture turns negative following…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT06210425
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Junhao Zheng
Kidney Stone, Retrograde Intrarenal Surgery (RIRS)
MIRABEGRON AND UAS OUTCOMES DURING RIRS
The aim of this study is to evaluate whether there is a difference in the passage rate of the ureteral access sheath between patients who used mirabegron (a beta-3 receptor agonist) for overactive bladder and those who underwent…
- Conditions
- Kidney Stone, Retrograde Intrarenal Surgery (RIRS), Ureteral Access Sheath
- Trial name
- NCT07566416
- Testing
- Retrograde intrarenal surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Ankara Training and Research Hospital
Renal Colic, Stone, Kidney
Use of POCUS and STONE Criteria Together in the Diagnosis of Nephrolithiasis
Patients presenting to the emergency department with symptoms suggestive of renal colic will be included in the study at Kocaeli City Hospital's emergency department.
- Conditions
- Renal Colic, Stone, Kidney, Hydronephrosis, Nephrolithiasis
- Trial name
- POCUS (NCT07126847)
- Testing
- Renal Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 490 people
- Sponsor
- Kocaeli City Hospital
Kidney Calculi, Ureteral Calculi
Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1.
- Trial name
- NCT07043374
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Kidney Stones
Effect of Negative Pressure Suction on Fluid Absorption and Infection in Flexible Ureteroscopy
The goal of this observational study is to learn about the effects of using negative pressure suction during retrograde intrarenal surgery (RIRS) in patients aged 18 and older with kidney stones.
- Trial name
- NCT07492147
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Lanzhou University Second Hospital
Kidney Stone, Ureteral Stone
Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off
The purpose of this study is to compare Moses 2.0 pulse modulation technology and the standard high powered Holmium Laser lithotripsy and how it will affect time in the operating room, time using the laser, laser energy, and…
- Trial name
- NCT06346483
- Testing
- Dusting without Moses 2.0 Modulation, Dusting with Moses 2.0 Modulation, Moses 2.0 Modulation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Northwestern University
Kidney Stone, Kidney Calculi
Evaluation of Infection in Obstructing Urolithiasis
Obstructing urolithiasis can be life-threatening in the setting of urinary tract infection. The purpose of this study is to identify and validate risk factors and markers for the presence of infection and development of sepsis…
- Conditions
- Kidney Stone, Kidney Calculi, Urinary Tract Obstruction, Infection
- Trial name
- eIOU (NCT04332861)
- Testing
- Initial clinical and laboratory evaluation
- Where
- 2 sites in United States
- Volunteers
- 477 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Stones
Flexible Ureteroscopy Versus ESWL in the Management of Lower Calyceal Stones
to assess safety, efficacy of Flexible ureteroscopy (FURS) holmium:YAG laser lithotripsy (LL) compared to extracorporeal shockwave lithotripsy (ESWL) in management of lower calyceal stones (LC) stones.
- Trial name
- NCT02658942
- Testing
- Ureteroscopy, Shockwave lithotripsy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Kidney Stones
FANS-Assisted Mini-PCNL for Complex Renal Stones
This prospective pilot study aims to evaluate the feasibility, safety, and preliminary clinical outcomes of a novel mini-percutaneous nephrolithotomy (mini-PCNL) technique integrating a flexible mini-nephroscope with a flexible…
- Trial name
- FANS-MiniPerc (NCT07332286)
- Testing
- FANS-assisted mini-percutaneous nephrolithotomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Renal Colic, Kidney Stone
Erector Spinae Plane Block for Uncomplicated Renal Colic
This research study is to determine how well the Erector Spinae Plane Block (ESPB) works for kidney stone pain and any possible side effects.
- Trial name
- NCT05625802
- Testing
- Erector Spinae Plane Block (ESPB), Ropivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Renal Stones
PCNL Versus RIRS for Management of Stones in Solitary Kidney
Few studies compared PCNL and RIRS for stones in solitary kidney. Current guidelines do not provide clear recommendations concerning the management of renal stones in patients with solitary kidney.
- Trial name
- NCT07730892
- Testing
- retrograde intra renal surgery (RIRS), percutaneous nephrolithotomy (PCNL)
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Mansoura University
Kidney Stones, Percutaneous Nephrolithotomy
Paravertebral Versus Caudal Block in Pediatric PCNL
To compare the efficacy of Ultrasound guided thoracic paravertebral block versus ultrasound guided caudal epidural block in pediatric patients undergoing percutaneous nephrolithotomy
- Trial name
- NCT05012215
- Testing
- Paravertebral, Caudal block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Kidney Stones, Nephrolithiasis
DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones
Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- NCT07516535
- Testing
- Direct In-Scope Suction, Flexible and Navigable Suction Ureteric Access Sheath
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Retrograde Intrarenal Surgery, Renal Stones
Retrograde Intrarenal Surgery Low Risk Trial
In the treatment of kidney stones and upper ureteral stones, flexible ureteroscopic lithotripsy has become the mainstream choice due to its minimally invasive nature and high safety.
- Trial name
- NCT06741917
- Testing
- Levofloxacin, Cefmetazole (drug)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital