Clinical trials: Renal Transplant
Renal Failure, Tremors
Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO)
This study will evaluate and measure symptomatic hand tremor in stable kidney transplant subjects on Prograf or generic tacrolimus maintenance therapy at baseline (pre-conversion) and following conversion to LCP-Tacro.
- Trial name
- STRATO (NCT01438710)
- Testing
- Prograf, LCP-Tacro
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- Veloxis Pharmaceuticals
End Stage Renal Disease
Trial of Adoptive Immunotherapy With TRACT to Prevent Rejection in Living Donor Kidney Transplant Recipients
Regulatory CD4+CD25+ T cells (Treg) derived from the thymus and/or peripheral tissues have been demonstrated to broadly control T cell reactivity (14).
- Trial name
- TRACT (NCT02145325)
- Testing
- Expanded Tregs
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Vascular Access Complication, Apheresis Related Complication
Vascular Access Complications for Therapeutic Apheresis in Nephrology
The aim of this study is to describe vascular access complications which are used for therapeutic apheresis in Nephrology.
- Trial name
- VACTANE (NCT05894317)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epstein-Barr Virus Infections
Evaluation of the Efficacy of a Treatment by One Single Dose of Rituximab (375mg/m2 ) in the Prevention of the Epstein Barr Virus (EBV) Primary Infection and Post-transplant Lymphoproliferative Disorder in Adult EBV Seronegative Patients Who Received an EBV Seropositive Kidney Allograft
Epstein Barr virus infects over 90% of human population and persists during lifetime. After infecting B lymphocytes, EBV remains latent in memory B cells.
- Trial name
- REPLY (NCT04989491)
- Testing
- Rituximab, control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Nephrotoxicity
Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients
Kidney damage is a major complication of current antirejection medicines used in transplantation. An increasing number of brittle diabetics are successfully receiving a pancreas transplant.
- Trial name
- NCT02103855
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University
Living-relative Kidney Transplantation
Induction With SVF Derived MSC in Living-related Kidney Transplantation
The objective of this trial is to determine if autologous SVF derived MSC can effectively reduce the need for post transplant immunosuppressant in living-relative kidney transplantation.
- Trial name
- NCT02492308
- Testing
- SVF-MSC induction, Basiliximab induction
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Fuzhou General Hospital
Renal Transplant
Study Evaluating Rapamune® Maintenance Regimen
Primary : To evaluate the efficacy of sirolimus assessed by the incidence of biopsy-confirmed acute rejection episode at 6 months after transplantation in Korean renal transplantation recipients. Secondary : 1.
- Trial name
- NCT00478608
- Testing
- Sirolimus (Rapamune®)
- Where
- 9 sites in South Korea
- Volunteers
- 79 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Schimke Immuno-osseous Dysplasia
Clinical Study on the Safety and Efficacy of CD7 CAR-T Cell Sequential Allo-HSCT and Kidney Transplantation in the Treatment of SIOD
A Clinical Study on the Safety and Effectiveness of CD7 CAR-T Cell Sequential Allo-HSCT and Kidney Transplantation in the treatment of Schimke immuno-osseous dysplasia
- Trial name
- NCT06769191
- Testing
- CD7 CAR-T cells injection, Allo-HSCT, Kidney Transplantation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Rejection of Kidney Allograft
Blood Biomarkers in Pediatric Kidney Transplant Recipients
The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody…
- Trial name
- Omnigraf (NCT05477082)
- Testing
- Observational group
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Minnesota
Heart Transplantation, Acute Kidney Injury
Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation
The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.
- Trial name
- HSS-HTx (NCT05909150)
- Testing
- Sodium chloride solution 3,5%, Sodium chloride solution 0,9%
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Fernando Bacal
Kidney Transplantation
A Study to Evaluate Efalizumab Compared With Cyclosporine As an Immunosuppressant Regimen in De Novo Renal Transplantation
This is a Phase II/III, randomized, open-label, active-controlled, multicenter trial to evaluate the safety and efficacy of efalizumab compared with cyclosporine (CsA), when both are given in combination with Mycophenolate…
- Trial name
- NCT00729768
- Testing
- basiliximab, efalizumab, mycophenolate mofetil
- Sponsor
- Genentech, Inc.
HIV, Awaiting Organ Transplant
HIV-to-HIV Transplant at MGH
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02750397
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
End Stage Renal Disease, Hepatitis C
Kidney Transplants in Hepatitis C Negative Recipients With Hepatitis C Viremic Donors
In this study, individuals without hepatitis C infection who are on the kidney transplant waitlist will receive a kidney from a deceased donor with hepatitis C infection and will be treated for hepatitis C at the same time.
- Trial name
- NCT04575896
- Testing
- Glecaprevir/pibrentasvir
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
End Stage Renal Failure on Dialysis
High Pressure Balloon vs Cutting Balloon
Patients suspected of having AV access stenosis will be referred to the Division of Vascular and Endovascular Surgery by the dialysis center.
- Trial name
- NCT03145662
- Testing
- high pressure balloon, cutting balloon
- Where
- United States
- Sponsor
- University of Toledo Health Science Campus
Chronic Kidney Disease
Pulsed Perfusion for Marginal Kidneys
Trends in organ donor pool are characterized by an increasing age and a shift towards cerebrovascular diseases as primary causes of death.
- Trial name
- PREDICTION (NCT02055950)
- Testing
- Storage of kidney in refrigerated solution, Kidney perfused by pulsatile machine
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Transplant; Failure, Kidney
A Pilot Study to Assess the Safety and Efficacy of Alefacept in de Novo Kidney Transplant Recipients
The purpose of this study is to assess Alefacept in combination with alemtuzumab induction and calcineurin inhibitor and corticosteroid withdrawal.
- Trial name
- NCT01163799
- Testing
- Alefacept (ASP0485)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Kidney Transplantation, Robotic Surgery
RAKT OUTCOME ANALYSIS
The goal of this observational study is to compare outcomes of robot-assisted kidney transplantation and open kidney transplantation.
- Trial name
- NCT06320821
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Renal Transplantation
Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients
This study will evaluate the safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney organ transplant
- Trial name
- NCT00239785
- Testing
- FTY720
- Volunteers
- 684 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplantation, Transplantation, Kidney
Belatacept and Risk of Post-transplant Lymphoproliferative Disorder in US Renal Transplant Recipients
To estimate the incidence rates of post-transplant lymphoproliferative disorder (PTLD) in adult, EBV seropositive, kidney alone transplant recipients treated with belatacept at the time of transplantation To estimate the…
- Trial name
- NCT01656343
- Testing
- Calcineurin inhibitors (CNI), Belatacept
- Volunteers
- 775 people
- Sponsor
- Bristol-Myers Squibb
Living Donor Nephrectomy
Kidney Donor Outcomes Cohort (KDOC) Study
Live donor kidney transplantation (LDKT) is important because its outcomes for recipients are superior to those of deceased donor transplantation, and it yields significant cost savings to the healthcare system overall.
- Trial name
- KDOC (NCT01427452)
- Where
- 7 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center