Clinical trials: Renal Transplant
Multiple Myeloma
Busulfan in Multiple Myeloma
Two main objectives of the study are: Primary: To determine the MTD of Busulfex ® that can be given safely over the least number of days to myeloma patients who are either ≥65 years of age (Group 1) or have renal insufficiency…
- Trial name
- NCT00934232
- Testing
- Busulfan
- Volunteers
- 13 people
- Sponsor
- Guido Tricot
Chronic Kidney Disease, Kidney Transplantation
Pilot Study Evaluating Doxercalciferol Replacement Therapy in Kidney Transplant Recipients
People with kidney transplants often develop bone disease. One reason for bone disease may be overactivity of a gland in the neck called the parathyroid gland.
- Trial name
- NCT00889629
- Testing
- Doxercalciferol, 25-OH Vitamin D3
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mariana Markell
Kidney Transplantation, Rejection
Monitoring Concentration and Pharmacodynamic Effects of Tacrolimus in Peripheral Blood Lymphocytes of Kidney Transplant Recipients
Therapeutic drug monitoring (TDM) of immunosuppressive drugs is used to improve the immunosuppressive effect while minimizing the toxicity related to exposition to high serum levels.
- Trial name
- NCT03425071
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Liver Transplantation, Renal Insufficiency, Chronic
Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and…
- Trial name
- NCT05326399
- Testing
- renal biospy
- Where
- 2 sites in China
- Volunteers
- 369 people
- Sponsor
- RenJi Hospital
Transplant;Failure,Kidney
Real-time Monitoring of Kidney Grafts on Hypothermic Machine Perfusion
A significant number of deceased donor kidneys donated for transplantation are not used and are thrown away due to lack of ways of checking their condition and function before the operation.
- Trial name
- REMO-HYMAP (NCT04619732)
- Testing
- Monitoring biochemical concentrations during cold machine perfusion
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Accunea Ltd.
Healthy, Chronic Kidney Diseases
Innovative Approach to Fecal Microbiota Transplantation (FMT) Applied for Chronic Kidney Disease (CKD)
The aim of this PhD project focuses on the relationship between intestinal microbiota and health in the background of Chronic Kidney Disease (CKD).
- Trial name
- NCT04222153
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Kidney Transplant; Complications, Liver Transplant; Complications
Project LIFT - Promoting Healthy Behavior Through a Wearable Fitness Device and Financial Incentives
Project LIFT is a randomized, controlled trial that tests the effectiveness of a remotely-monitored, home-based exercise program utilizing wearable fitness trackers to monitor steps taken per day, health engagement questions, and…
- Conditions
- Kidney Transplant; Complications, Liver Transplant; Complications, Obesity
- Trial name
- LIFT (NCT03221465)
- Testing
- Self-monitoring of physical activity with incentives, Usual care and self-monitoring of physical activity
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
Renal Transplantation
Long Term Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients
This study will evaluate the long term safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney organ transplant
- Trial name
- NCT00239811
- Testing
- FTY720
- Volunteers
- 684 people
- Sponsor
- Novartis Pharmaceuticals
Wilms Tumor, Fibrosarcoma
Study of High-Dose Chemotherapy With Bone Marrow or Stem Cell Transplant for Rare Poor-Prognosis Cancers
The purpose of this study is to determine whether very high dosages of chemotherapy will improve the chance of surviving cancer.
- Conditions
- Wilms Tumor, Fibrosarcoma, Carcinoma, Round Cell, Nasopharyngeal Cancer
- Trial name
- NCT00141765
- Testing
- Myeloablative Chemotherapy, Stem Cell Rescue
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan Rogel Cancer Center
Sexual Dysfunction
Sexual Dysfunction After Renal Transplantation
A questionnaire will be send to kidney transplant recipients to investigate characteristics of them and their sexual function, all participants in the survey are anonymous and voluntary, then analyse these characteristics.
- Trial name
- NCT05856929
- Testing
- no Intervention
- Where
- 2 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Transplant Dysfunction
Safety and Effect of Low-Energy Extracorporeal Shockwave Therapy (ESWT) on the Renal Allograft in Transplant Recipients.
The aim is to investigate the safety and potential effect of Low-energy Shockwave Therapy (ESWT) on the transplanted kidney. The treatment consist of ESWT two times a week for three weeks, six treatments in total.
- Trial name
- NCT03602807
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Gallbladder Stones, Kidney Transplantation
Silent Gallbladder Stone in Kidney Transplantation Recipients: Should it be Treated?
Treatment and follow-up strategies for silent gallbladder (GB) stones in patients before KT (Kidney transplantation) remain unknown.
- Trial name
- NCT05945511
- Where
- South Korea
- Volunteers
- 2,295 people
- Sponsor
- Seoul National University Hospital
AA Amyloidosis
Recurrent AA Amyloidosis After Renal Transplantation
End-stage renal disease related to AA amyloidosis is well characterized but there is limited data concerning patient and graft outcomes after renal transplantation.
- Trial name
- NCT02704065
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Kidney Transplantation, Kidney Transplant Rejection
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient…
- Trial name
- SIMPLE (NCT04773392)
- Testing
- Twice-daily Tacrolimus, Once-daily envarsus XR, Induction Immunosuppression with Basiliximab or Rabbit Anti Thymoglobulin (rATG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Hyperglycemia, Renal Transplant Complication Primary Non-Function
Semaglutide Treatment for Hyperglycaemia After Renal Transplantation
Background: Post-transplant hyperglycaemia occurs frequently in renal transplant recipients within the first two weeks after transplantation.
- Conditions
- Hyperglycemia, Renal Transplant Complication Primary Non-Function, Diabetes
- Trial name
- Sema-RTx (NCT05702931)
- Testing
- Semaglutide 14 MG [Rybelsus]
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
End Stage Renal Disease
CellCept/Iron Study: The Iron Ion-Mycophenolate Mofetil Chelation Complex Interaction in Renal Allograft Recipients
The objective of this study is to determine the extent and magnitude of the pharmacokinetic drug interaction between mycophenolate mofetil (MFF) (under Css conditions) in the presence of iron in renal transplant recipients.
- Trial name
- NCT00227045
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Kidney Transplant Rejection
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03363945
- Testing
- MDR-101
- Where
- 19 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Medeor Therapeutics, Inc.
Renal Interstitial Fibrosis
Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant Recipients
Recently, early biomarkers of renal interstitial fibrosis have been identified, amongst them de novo expression of vimentin by tubular epithelial cells, which is an intermediate filament, and the translocation of beta-catenin…
- Trial name
- CERTITEM (NCT01079143)
- Testing
- Certican®, Neoral, Myfortic
- Where
- 23 sites in France
- Volunteers
- 194 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Myeloma, Renal Failure
High Dose Therapy Followed by Autologous Transplantation for Myeloma Patients With Severe Renal Impairment
Multiple myeloma (MM) is a malignant plasma cell disorder, characterized by the presence of more than 10 % of clonal plasma cells in the bone marrow.
- Trial name
- IRMYG (NCT03234335)
- Testing
- Data collection
- Where
- 33 sites in Algeria, Belgium and 2 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Delayed Graft Function
Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney
The major objective is to demonstrate the safety and efficacy of ANG-3777 in improving graft function and reducing the severity of delayed graft function (DGF) in recipients at high risk of DGF after receiving a deceased donor…
- Trial name
- NCT02474667
- Testing
- ANG-3777
- Where
- 30 sites in United States
- Volunteers
- 253 people
- Sponsor
- Angion Biomedica Corp