Clinical trials: Renal Transplant Recipient
Kidney Transplantation
Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
Efficacy and safety of AEB071 in combination with mycophenolate acid sodium, basiliximab and steroids in preventing acute rejection after kidney transplantation.
- Trial name
- NCT00492869
- Testing
- AEB071
- Where
- 41 sites in United States, Belgium and 5 more
- Volunteers
- 124 people
- Sponsor
- Novartis Pharmaceuticals
Medication Adherence
Medication Adherence in Kidney Transplant Recipients Using Automated Reminders and Provider Notification
Novel wireless technology has created inexpensive tools that allow both accurate monitoring of adherence to pills as well as real-time interventions such as automated reminders in the event of a missed dose.
- Trial name
- NCT01541384
- Testing
- Vitality GlowCaps
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Kidney Transplant Recipients
Immunological Follow-up After SARS CoV2 Vaccination in Kidney Transplant Recipients
The investigators goal is to assess the vaccine response of kidney transplant patients following vaccination against SARS-CoV-2.
- Trial name
- COVATRHUS (NCT04757883)
- Testing
- Study of the synthesis of antibodies directed against SARS
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Transplant, Cardiovascular Disease
Randomized Trial of SGLT2i in Heart Transplant Recipients
Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival.
- Conditions
- Heart Transplant, Cardiovascular Disease, Kidney Disease
- Trial name
- NCT06625073
- Testing
- Empagliflozin
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Renal Transplantation
Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients
The purpose of this study is to evaluate if the delayed administration of everolimus could reduce the everolimus associated "anti-proliferative complications" (e.g.
- Trial name
- NCT00154297
- Testing
- Everolimus (RAD001)
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Renal Transplantation; Complication
Hypomagnesemia and Its Association With Calcineurin Inhibitors Use in Renal Transplant Recipients
To assess the prevalence and risk factors of hypomagnesemia and its association with calcineurin inhibitor use among Egyptian renal transplant recipients.
- Trial name
- NCT05352880
- Testing
- serum magnesium level, FEMg
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Hyperkalemia, Kidney Transplant
Effects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients
Patiromer lowers potassium effectively in patients with hyperkalemia and chronic kidney disease. Patients with a kidney transplant usually have reduced renal function and may also develop hyperkalemia.
- Trial name
- TACPAT (NCT05029310)
- Testing
- Patiromer Oral Product
- Where
- Norway
- Volunteers
- 13 people
- Sponsor
- Oslo University Hospital
Sensitized Kidney Transplant Recipients
Identification of Donor Specific B Cells and Antibody Mediated Rejection
Many people who are on the wait list for a kidney transplant have harmful antibodies, called donor specific antibodies (DSA), which will attack foreign tissue such as the transplanted organ.
- Trial name
- NCT02133248
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Kidney Transplant; Complications, Diabetes Mellitus, Type 2
Use of CGM in Kidney Transplant Recipients
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
- Conditions
- Kidney Transplant; Complications, Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
- Trial name
- NCT04783441
- Testing
- Dexcom G6, Dexcom G6 blinded sensor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Davis
Lung Transplantation
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
This trial evaluated the efficacy of an everolimus-based quadruple low immunosuppressive regimen versus a standard immunosuppressive regimen concerning kidney function in lung transplant recipients.
- Trial name
- 4EVERLUNG (NCT01404325)
- Testing
- standard therapy, Everolimus
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
CMV Infection, CMV Viremia
Real-world CMV Outcomes Among Kidney Transplant Recipients in Brazil
This is a single-center, non-interventional, retrospective study of data, at the level of the individual without identification, extracted from medical records of adult patients undergoing a kidney transplant procedure after 1st…
- Trial name
- NCT06263218
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Hospital do Rim e Hipertensão
Renal Transplant
CellCept® Dose Adjustment Versus Fixed Dose (Standard Care) in Renal Transplant Recipients
In order to avoid renal transplant rejection, the immune system should be suppressed. After the renal transplant subjects are treated with a combination of two to four different types of immunosuppressive drugs.
- Trial name
- MMF (NCT00737659)
- Testing
- Mycophenolate mofetil (CellCept® )
- Where
- 2 sites in Israel
- Volunteers
- 138 people
- Sponsor
- Rabin Medical Center
Renal Transplant Patients
CNS Study of Patients Switching From Tacrolimus to Envarsus
This is a pilot study documenting the neurotoxic side effects including tremors in patients with a stable graft who are receiving Tacrolimus following kidney transplantation.
- Trial name
- NCT03270462
- Testing
- Envarsus XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Proteinuria, Transplant Glomerulopathy
Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients
The goal of this study is to evaluate the benefit of ACTH (Acthar) in reducing proteinuria associated with transplant glomerulopathy in non-diabetic kidney transplant recipients.
- Trial name
- NCT02057523
- Testing
- Acthar
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Illinois Chicago
Epstein-Barr Virus Infections
Evaluation of the Efficacy of a Treatment by One Single Dose of Rituximab (375mg/m2 ) in the Prevention of the Epstein Barr Virus (EBV) Primary Infection and Post-transplant Lymphoproliferative Disorder in Adult EBV Seronegative Patients Who Received an EBV Seropositive Kidney Allograft
Epstein Barr virus infects over 90% of human population and persists during lifetime. After infecting B lymphocytes, EBV remains latent in memory B cells.
- Trial name
- REPLY (NCT04989491)
- Testing
- Rituximab, control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Transplant, Kidney Transplant Failure
Dapagliflozin in Living-Donor Kidney Transplant Recipients
This randomized, open-label, single-center clinical trial aims to evaluate the effect of dapagliflozin on kidney allograft function in adult recipients of a first living-donor kidney transplant.
- Trial name
- DAPA-GRAFT (NCT07555106)
- Testing
- Dapagliflozin (10mg Tab), Standard of Care
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- University of Guadalajara
Kidney Transplantation, Mycophenolate Mofetil
Reduced Immunosuppression in Older Renal Transplant Recipients With Trugraf®/TRAC Monitoring (RIOT Trial): A Prospective, Randomized, Multicenter Trial.
The purpose of this research is to determine the safety and efficacy of withdrawing MMF (Mycophenolate Mofetil) in kidney transplant recipients who are 55 years or older at the time of receiving a kidney transplant.
- Trial name
- RIOT (NCT06568549)
- Testing
- Mycophenolate Mofetil (MMF) Maintenance Group, Mycophenolate Mofetil (MMF) Withdrawal Group
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Kidney Disease
SystemCHANGE: An Intervention for Medication Change in Adult Kidney Transplant Patients
With kidney transplant (KT) recipients as our exemplar population, our goal is to develop and test interventions that increase medication adherence (MA) in chronically ill adults.
- Trial name
- MAGIC (NCT02416479)
- Testing
- SystemCHANGE, Patient-education attention control
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Cynthia Russell
Renal Transplantation
A Twelve-month, Multicenter, Open-label, Randomized Study of the Safety, Tolerability and Efficacy of Everolimus With Basiliximab, Corticosteroids and Two Different Exposure Levels of Tacrolimus in de Novo Renal Transplant Recipients
This study is designed to evaluate whether tacrolimus dose reduction in de novo renal recipients receiving everolimus can preserve renal function while maintaining efficacy.
- Trial name
- NCT00369161
- Testing
- Everolimus (RAD001), Tacrolimus, Basiliximab
- Where
- Switzerland
- Volunteers
- 228 people
- Sponsor
- Novartis
Kidney Transplant Recipients
Exercise and Diet Effects in Reducing Cardiovascular Risk in Kidney Transplant Recipients
The goal of this clinical trial is to assess whether, over an observation period of 3 years, there is a reduction in cardiovascular risk, and the extent of this reduction, in a group of adult kidney transplant patients undergoing…
- Trial name
- KT-LIFESTYLE (NCT06806670)
- Testing
- lifestyle intervention
- Where
- Italy
- Volunteers
- 275 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna