Clinical trials: Renal Transplant Recipient
Kidney Transplantation, Renal Transplantation
Envarsus XR® in Adolescent Renal Transplant Recipients
Adolescents commonly experience barriers to adherence that entail forgetfulness, distraction, poor planning, and scheduling problems.
- Conditions
- Kidney Transplantation, Renal Transplantation, Grafting, Kidney
- Trial name
- EnvarsusXR (NCT03266393)
- Testing
- Envarsus XR, Tacrolimus
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Los Angeles
Renal Transplanted Recipients
SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus
The aim of this study is to assess the safety and efficacy of corticosteroid discontinuation versus cyclosporine micro emulsion discontinuation in recipients receiving reduced exposure cyclosporine micro emulsion and…
- Trial name
- NCT00371826
- Testing
- Everolimus (RAD001), Cyclosporine (Calcineurin Inhibitor (CNI)), Methylprednisone/prednisone
- Where
- 7 sites in Australia
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Influenza
Adjuvanted Influenza Vaccine Evaluation in Kidney Transplant Recipients
Influenza is an important public health problem. Organ transplant patients are particularly susceptible to severe disease. Also, they shed higher quantities of virus for longer durations, leading to greater contagious potential…
- Trial name
- NCT01584908
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- University of Alberta
Hypertension, Gut -Microbiota
How a Plant-Based Diet Affects Blood Pressure and Gut Health in Kidney Transplant Patient
Kidney transplant improves the quality of life (QoL) and survival of appropriate patients with advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD).
- Conditions
- Hypertension, Gut -Microbiota, Kidney Function, Quality of Life (QOL)
- Trial name
- PLANET-KT (NCT06871722)
- Testing
- Plant based diet
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Mahidol University
Kidney Transplant, Drug-Related Side Effects and Adverse Reactions (MeSH Term)
The Effect of the 5th Sign Intervention on Medication Adherence in Kidney Transplant Recipients
The goal of this randomized controlled trial is to evaluate the effectiveness of the "5th Sign" intervention program-a multi-component strategy based on the Socio-Ecological Model that incorporates goal setting, action planning…
- Conditions
- Kidney Transplant, Drug-Related Side Effects and Adverse Reactions (MeSH Term), Medication Adherence, Mobile Applications
- Trial name
- NCT07851142
- Testing
- 5th Sign Intervention Program
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dokuz Eylul University
Liver Transplantation
Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients
This trial was designed to address important issues that impact recipients of liver allografts as well as clinicians, ie, renal function, reduction or discontinuation of tacrolimus early post-transplantation, and progression rate…
- Trial name
- RAD (NCT00622869)
- Testing
- Tacrolimus (reduced tacrolimus), Tacrolimus (tacrolimus elimination), Tacrolimus (tacrolimus control)
- Where
- 91 sites in United States, Argentina and 17 more
- Volunteers
- 719 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Allograft Dysfunction in Renal Transplantation
Everolimus Rescue Immunosuppression in the Treatment of Chronic Allograft Dysfunction in Renal Transplant Recipients
Despite the remarkable improvement in short-term patient and graft survival among the recipients of kidney transplants, the progressive renal dysfunction (chronic allograft dysfunction) accompanied by chronic interstitial…
- Trial name
- NCT01046045
- Testing
- everolimus
- Where
- Hong Kong
- Volunteers
- 17 people
- Sponsor
- Chinese University of Hong Kong
Renal Transplantation
Behavioral Contract Adherence Intervention
There is a critical gap in the knowledge on how to implement effective interventions for renal transplant recipients (RTRs) to improve immunosuppressant therapy (IST) adherence and clinical outcomes.
- Trial name
- NCT01739803
- Testing
- Behavioral Contract
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Tennessee
Kidney Disease, Liver Transplantation
Evaluation of Kidney Disease in Liver Transplant Recipients
A non-invasive urinary test that detects kidney injuries in liver transplant (LT) candidates would be useful for monitoring of kidney damage.
- Trial name
- NCT00585429
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
SARS-CoV-2 Infection, Active Immunization
Saxon SARS-CoV-2 Infection and Vaccination Study in Dialysis Patients, Solid Organ Recipients and Staff
To investigate short- (3 and 8 weeks) and long-term (6, 9, 12, and 18 months) immune protection or response at the humoral and cellular levels before and after SARS-CoV-2 infection or vaccination in patients with moderately…
- Conditions
- SARS-CoV-2 Infection, Active Immunization, Immune Response, Immunosuppression
- Trial name
- DIA-Vacc (NCT04799808)
- Where
- Germany
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Proteinuria
Oral Paricalcitol in Renal Transplant Recipients for Reducing Albuminuria
The main objective of this study is to examine if paricalcitol may reduce progression of graft fibrosis and proteinuria in kidney transplant patients.
- Trial name
- NCT01694160
- Testing
- Paricalcitol
- Where
- Norway
- Volunteers
- 77 people
- Sponsor
- Oslo University Hospital
Kidney Transplantation
Pilot Study to Investigate a Steroid Free Immunosuppressive Regimen for Renal Transplant Recipients
The main purpose of this study is to investigate, whether a steroid free immunosuppressive treatment is a valuable alternative in the treatment of de novo kidney transplant recipients and if it is possible to withdraw calcineurin…
- Trial name
- NCT00306397
- Testing
- Rapamycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Transplantation Infection, Renal Transplant Donor of Left Kidney
TransplantLines Food and Nutrition Biobank and Cohort Study (TxL-FN)
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing.
- Trial name
- TxL-FN (NCT02811835)
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Hemodialysis, Renal Transplantation
Influenza Vaccination in Hemodialysis Patients and Renal Transplant Recipients
Disturbances of acquired immunity are considered to be responsible, at least partly, for the high infection rate and inadequate response to vaccinations observed in hemodialysis (HD) patients and renal transplant recipient (RTR).
- Trial name
- NCT00776750
- Testing
- trivalent split influenza vaccine
- Where
- Belgium
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatitis C Virus Infection
Safety and Efficacy of Ledipasvir/Sofosbuvir (LDV/SOF) Fixed Dose Combination (FDC) for 12 or 24 Weeks in Kidney Transplant Recipients With Chronic HCV Infection
This study will evaluate the safety, tolerability, and antiviral efficacy of ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) for 12 or 24 weeks in adults with chronic genotype 1 or genotype 4 hepatitis C virus (HCV)…
- Trial name
- NCT02251717
- Testing
- LDV/SOF
- Where
- 5 sites in Austria, France and 2 more
- Volunteers
- 114 people
- Sponsor
- Gilead Sciences
Organ Donation, Liver Transplantation
EPI-STORM: Cytokine Storm in Organ Donors
Kidney and liver transplantation are the treatment of choice and are often the last therapeutic option offered to patients with chronic renal and liver failure.
- Conditions
- Organ Donation, Liver Transplantation, Kidney Transplantation, Graft Dysfunction
- Trial name
- EPI-STORM (NCT03786991)
- Testing
- No intervention
- Where
- 4 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Université de Sherbrooke
Kidney Diseases
The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients
This study was done to find out which treatment, tacrolimus or sirolimus, leads to better long-term kidney function in kidney transplant patients.
- Trial name
- NCT00275535
- Testing
- Anti-thymocyte globulin, Mycophenolate mofetil, Prednisone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Mayo Clinic
Lung Transplantation
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
This trial evaluated the efficacy of an everolimus-based quadruple low immunosuppressive regimen versus a standard immunosuppressive regimen concerning kidney function in lung transplant recipients.
- Trial name
- 4EVERLUNG (NCT01404325)
- Testing
- standard therapy, Everolimus
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplant, Kidney Transplantation
Proteogenomic Biomarker Panels in a Serial Blood & Urine Monitoring Study of Kidney Transplant Recipients
There is a need to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had kidney transplant.
- Trial name
- PROGENI-KI (NCT01289717)
- Where
- 5 sites in United States
- Volunteers
- 307 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant, Transplant Recipients
AI-Assisted vs Usual Follow-up in Kidney Transplantation
The goal of this clinical trial is to learn whether kidney transplant follow-up visits run by a health professional using an artificial intelligence (AI) computer helper are as good as usual follow-up visits with a doctor.
- Trial name
- FOLLOW-KTx (NCT07842289)
- Testing
- AI-Assisted Follow-up Consultation, Usual Physician-Led Follow-up Consultation
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp