Clinical trials: Renal Transplant Recipient
Kidney Failure, Chronic
MIC Cell Therapy for Individualized Immunosuppression in Living Donor Kidney Transplant Recipients
A phase- I clinical trial to determine safety and feasibilty of intravenous administration of mitomycin C-treated donor peripheral blood mononuclear cells in patients with chronic kidney disease stage KDIGO 4 or 5 (i.e.
- Trial name
- TOL-1 (NCT02560220)
- Testing
- Mitomycin C-induced peripheral blood mononuclear cells (MICs)
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Heidelberg University
Kidney Transplantation, Ischemia-Reperfusion Injury
Thymoglobulin Induction in Kidney Transplant Recipients
The purpose of this study is to determine if anti-thymocyte globulin (Thymoglobuline) administration in the kidney transplant recipient is able to reduce the amount of damage that kidneys transplanted from deceased donors…
- Trial name
- TIKT (NCT01239563)
- Testing
- antithymocyte globulin, Basiliximab
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Kidney Transplantation
TOlerance MOlecular and Genome-wide Studies With Renal Allograft Recipient Material
TOMOGRAM is a European multicentric, prospective, experimental, controlled study that aims to increase our understanding of the causative mechanisms of operational tolerance in kidney transplantation through the achievement of…
- Trial name
- TOMOGRAM (NCT05124444)
- Testing
- High throughput DNA and RNA sequencing
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Kidney Diseases
Comparison of Sirolimus to Tacrolimus for Long Term Therapy in Kidney Transplant With no Steroids
Kidney transplant patients will be treated with Thymoglobulin (5 days), tacrolimus (Prograf), and mycophenolate mofetil (Cellcept) from the time of transplant.
- Trial name
- NCT00170053
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Mayo Clinic
BK Virus (BKV) Viremia
BK Virus Infection (Viremia) Natural History in Renal Transplant Recipients
The objectives of this study is to establish the natural history of BK virus viremia and other possible opportunistic viral pathogens in renal transplants recipients.
- Trial name
- NCT01782209
- Where
- 6 sites in United States
- Volunteers
- 335 people
- Sponsor
- University of Alabama at Birmingham
Kidney Transplant, Kidney Transplant Donor
Outcomes of a Pre-operative Exercise Programme for Live Donor and Recipient Kidney Transplant Patients
The goal of this clinical trial is to learn if a pre-operative outpatient exercise programme, monitored by a smart wearable device is acceptable to live kidney donor and recipient transplant patients.
- Conditions
- Kidney Transplant, Kidney Transplant Donor, Kidney Transplant Recipient
- Trial name
- OPERATe (NCT06858098)
- Testing
- Exercise programme, Wearable smart device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Manchester
Chronic Kidney Disease
Pedometers to Assess and Increase Physical Activity Among Children With Chronic Kidney Disease
Hypothesis #1: Most children with CKD stages 2-4, ESRD and kidney transplantation will report participation in physical activity that falls short of recommended levels of physical activity; Children on dialysis will be less…
- Trial name
- NCT01270529
- Testing
- Increasing Physical activity
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Cytomegalovirus Disease, Kidney Transplant Infection
A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus
This was a randomized, double-blind, double-dummy, parallel-group, multicenter study of the efficacy, safety, and tolerability of oral brincidofovir (BCV) versus valganciclovir for the prevention of cytomegalovirus (CMV) disease…
- Trial name
- NCT02439957
- Testing
- Brincidofovir, Valganciclovir
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Jazz Pharmaceuticals
Kidney Transplant Recipients
Observational Study to Evaluate the Safety and Efficacy of ATG-F on Kidney Transplant Recipients
A multicenter, prospective, observational study to evaluate the safety and efficacy of individual batches of ATG-F in kidney transplant recipients.
- Trial name
- NCT02392312
- Testing
- ATF-Fresenius S
- Where
- 25 sites in China
- Volunteers
- 950 people
- Sponsor
- Astellas Pharma China, Inc.
Kideny Transplant Recipients With High Cardiovascular Risk Score
PCSK 9 Inhibition as Secondary Prevention in Renal Transplant Patients
From this randomized controlled study, we aim to: A.Do do cardiovascular risk stratification of renal transplant recipients who are followed up in Hamed Al-Essa organ transplant center of Kuwait. B.
- Trial name
- NCT04665830
- Testing
- Evolocumab
- Where
- Kuwait
- Volunteers
- 200 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Kidney Transplant Recipients
Concentration Controlled Versus Fixed Dose of MMF in Kidney Transplant Recipients
Acumulating data suggest that thrapeutic drug therapeutic may optimize efficacity and tolerance of MMF. It could guarantee better exposure to the drug in the first 3 months and then minimize side effects in the long term.
- Trial name
- NCT00199667
- Testing
- Mycophenolate Mofetil
- Where
- 11 sites in France
- Volunteers
- 137 people
- Sponsor
- University Hospital, Limoges
Prostate Cancer, Renal Transplantation
Prostate Cancer in Renal Transplants Recipients
Kidney transplantation is considered the standard of care for patients with end-stage kidney disease under chronic dialysis treatment.
- Conditions
- Prostate Cancer, Renal Transplantation, Kidney Transplant Recipients
- Trial name
- RENPRO (NCT04642833)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Florence
Kidney Failure, Graft Rejection
Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients
The purpose of this study is to test two different sirolimus-based immunosuppressive regimens for elderly kidney transplant recipients.
- Conditions
- Kidney Failure, Graft Rejection, Aged
- Trial name
- NCT00254709
- Testing
- Sirolimus
- Volunteers
- 66 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Heart Transplantation, Kidney Transplantation
Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection.
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation
- Trial name
- NCT00531921
- Where
- 5 sites in United States
- Volunteers
- 313 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asymptomatic Bacteriuria, Pyelonephritis
Antibiotic Treatment Versus no Therapy in Kidney Transplant Recipients With Asymptomatic Bacteriuria
Objective: To determine whether antibiotic treatment of asymptomatic bacteriuria in kidney transplant recipients could be useful to prevent pyelonephritis in these patients.
- Trial name
- BAC01 (NCT01771432)
- Testing
- Antibiotic treatment, No treatment
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Núria Sabé Fernàndez
Kidney Transplant; Complications, Diabetes Mellitus
Effect of Empagliflozin vs Linagliptin on Glycemic Outcomes,Renal Outcomes & Body Composition in Renal Transplant Recipients With Diabetes Mellitus
In the early postoperative period, hyperglycemia is frequently seen in renal transplant recipients primarily because of high doses of immunosuppressive therapy. Many of these patients have pre-existing type 2 diabetes (T2D).
- Trial name
- EmLinaRenal (NCT06095492)
- Testing
- Empagliflozin 25 MG, Linagliptin
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Medanta, The Medicity, India
Cytomegalovirus Infections, CMV
Cytomegalovirus Risk in Seropositive Kidney Transplant Recipients Stratified by Quantiferon-CMV
To evaluate the Quantiferon-CMV test ability to predict occurrence of cytomegalovirus (CMV) disease o treated infection after kidney transplantation.
- Conditions
- Cytomegalovirus Infections, CMV, Kidney Transplant Infection
- Trial name
- NCT03858907
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- University of Sao Paulo General Hospital
Kidney Transplantation
Use of Sirolimus vs. Tacrolimus For African-American Renal Transplant Recipients
The purpose of this study is to evaluate the efficacy of Sirolimus (Rapamune) in improving the function of the transplant kidney, without any increase in the risk of acute rejection or adverse side effects, compared with…
- Trial name
- NCT00252655
- Testing
- Rapamune and Prograf
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wayne State University
Absence; Kidney
Sirolimus Conversions in African-American Renal Transplant Recipients
This study's focus is to compare the level effectiveness and safety of regimens involving Sirolimus, Cellcept and steroid to Prograf, Sirolimus and steroid in African-American recipients of kidney transplants.
- Trial name
- NCT01005706
- Testing
- rapamune, mycophenolate mofetil and steroid, tacrolimus, sirolimus and steroid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Kidney Transplantation, Hepatitis C
The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients
This is an open-label, pilot trial to test the safety and efficacy of transplantation of kidneys from hepatitis C seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative…
- Trial name
- NCT03809533
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Amit D Tevar, MD