Clinical trials: Renal Transplant Recipient
Heart Transplantation
A Study Investigating the Renal Tolerability, Efficacy, and Safety of a CNI-free Versus a Standard Regimen in de Novo Heart Transplant (HTx) Recipients
This study will assess whether a calcineurin inhibitor (CNI)-free regimen with everolimus and mycophenolic acid is associated with a better renal outcome as compared to the standard regimen containing cyclosporine A (which…
- Trial name
- MANDELA (NCT00862979)
- Testing
- Everolimus (EVR), cyclosporine A (CyA), tacrolimus (TAC)
- Where
- 9 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Failure, Chronic, Covid19
Assessment of Immune Response After Vaccination Against COVID-19 in Patients Treated With Renal Replacement Therapy
Chronically dialyzed patients and kidney transplant recipients have been identified as particularly vulnerable to SARS-CoV-2 infection due to unavoidable exposure.
- Conditions
- Kidney Failure, Chronic, Covid19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- COViNEPH-1 (NCT04905862)
- Testing
- Immune response, Solicited common and expected adverse reactions shortly following vaccination (reactogenicity), use of antipyretic or pain medications and unsolicited adverse events and serious adverse events
- Where
- 4 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Kidney Transplantation
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients
n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients.
- Trial name
- NCT01872455
- Testing
- n-3 rich diet, Usual diet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federico II University
Kidney Transplant Recipient, Kidney Transplant Donor
Investigation of the Effects of Quadratus Lumborum Block Applied to Patients in Kidney Transplant Surgery
This study aims to determine the most effective and long-lasting pain relief method for post-operative analgesia in kidney donor and recipient patients in kidney transplantation programme with the least invasive and least drug…
- Trial name
- NCT06011850
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Tuberculosis (TB), End-Stage Kidney Disease
Evaluation of IGRA, Symptoms and Chest Radiograph for Subclinical TB Detection in ESRD and KT
This is an observational study among approximately 160 end-stage renal disease patients on renal replacement therapy and post-living donor or deceased donor kidney transplant recipients.
- Trial name
- NCT06700876
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Kidney Transplant Rejection, Immunosuppression
Immunosuppression Management in Renal Transplant Recipients With Transplant Excellence Based on TruGraf Test
This is an investigator-initiated, single-center, prospective, randomized, proof of concept study. In this study patients who are status post kidney transplantation and meet the inclusion and exclusion criteria will undergo…
- Trial name
- NCT04670926
- Testing
- TruGraf, Standard of Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Transplant Genomics, Inc.
Kidney Tansplant, Acute Rejection (AR) of Transplanted Kidney
Daratumumab for Late Antibody-Mediated Rejection
The study titled "Daratumumab for Late Antibody-Mediated Rejection in Kidney Transplant Recipients with De Novo Donor-Specific Antibodies" (DARTABMR) is a case-control investigation assessing whether daratumumab is more effective…
- Trial name
- DARTABMR (NCT07081126)
- Testing
- Daratumumab (Subcutaneously), control group
- Where
- Slovakia
- Volunteers
- 20 people
- Sponsor
- University Hospital, Martin
Chronic Kidney Disease
Reduced Calorie Diet Intervention in Kidney Transplant Recipients
The purpose of this study is to measure the effect of a reduced calorie diet intervention in new kidney transplant recipients on the outcomes weight gain, oxidative stress, and insulin resistance.
- Trial name
- NCT00994838
- Testing
- reduced calorie diet
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Renal Transplant
The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function
Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease.
- Trial name
- NCT03107858
- Testing
- Norepinephrine, Dopamine
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
BK Polyomavirus, Kidney Diseases
Study of FK778 in Renal Transplant Recipients With Untreated BK Nephropathy
The purpose of this study is to assess the safety and effectiveness of a new oral immunosuppressant agent compared to standard care in renal transplant patients diagnosed with BK nephropathy.
- Trial name
- NCT00104338
- Testing
- FK778
- Where
- 21 sites in United States
- Volunteers
- 45 people
- Sponsor
- Astellas Pharma Inc
Difference of 12-hour AUC
Pharmacokinetic of Everolimus and Atorvastatin Co-administration
Hypothesis : In renal transplantation recipient who received immunosuppressive drug "certican" and have hypercholesterolemia will get lipid lower drug-HMG Co-A reductase inhibitors.
- Trial name
- NCT01780948
- Testing
- Atorvastatin 20 mg, Everolimus
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Chulalongkorn University
CMV Viral Loads in Seropositive Renal Transplant Recipients
Study of CMV in Kidney Transplant Recipients
Using novel CYTOF technology to measure a wide array of innate and adaptive cell proportions and cytokine levels, we plan a pilot study in old (>/=60 years) and young (20-40 years) renal transplant recipients who are…
- Trial name
- NCT02061215
- Testing
- CMV viral load
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
COVID-19, Renal Transplant Infection
COVID-19 Infection
Post-transplant patients with COVID-19 infection who attended Shenzhen No. 3 Hospital from December 2022 to February 2023, and enrolled the general population with COVID-19 infection who were hospitalized during the same period…
- Trial name
- NCT05926076
- Testing
- Treatment plan
- Where
- China
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- Tianjin First Central Hospital
Cytomegalovirus Infections, Heart Transplantation
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
Context Cytomegalovirus (CMV) infection is a frequent and potentially severe event in solid organ transplant (SOT) recipients. Most of available treatment display adverse effects that limit their use.
- Conditions
- Cytomegalovirus Infections, Heart Transplantation, Kidney Transplantation, Lung Transplantation
- Trial name
- QUANTIFOT (NCT06341543)
- Testing
- Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes)., Communication of the result of the QF-CMV to the clinician in charge
- Where
- France
- Volunteers
- 288 people
- Sponsor
- University Hospital, Grenoble
Kidney Transplantation
Testing the Effect of KnowMAP (Knowledge Management for Renal Transplant Recipients). A Randomized Controlled Study
A randomized controlled study (RCT) aiming to test the effect of a new health literacy intervention for renal transplant recipients, KnowMAP (knowledge management for renal transplant recipients).
- Trial name
- KnowMAP (NCT04296955)
- Testing
- Motivational interview as a new health communication intervention
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Kidney Transplant; Complications, Vascular Diseases
Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients
Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the…
- Conditions
- Kidney Transplant; Complications, Vascular Diseases, Diabetes
- Trial name
- NCT06140537
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Hyperkalemia, Kidney Transplant
Pharmacokinetic Study of Tacrolimus and Mycophenolate Mofetil in Kidney Transplant Recipients With Hyperkalemia Receiving Patiromer
Hyperkalemia (high potassium in blood) is a common condition found in kidney transplant patients. Risk factors include poor kidney function and exposure to various drugs.
- Trial name
- NCT03229265
- Testing
- Patiromer
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- The Rogosin Institute
Kidney Transplant; Complications
The Effect of Sodium Bicarbonate (Nephrotrans®) on Calcification Propensity of Serum in Kidney Transplant Recipients
This is a single-center, prospective, open-label, randomized, cross-over study.
- Trial name
- NCT03301558
- Testing
- Low dose sodium bicarbonate, High dose sodium bicarbonate
- Where
- Austria
- Sponsor
- Prim. Priv. Doz. Dr. Daniel Cejka
Chronic Kidney Diseases, Renal Transplantation
Remimazolam Infusion in Kidney Transplant Patients: A Multicenter Study
The goal of this clinical trial is to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of remimazolam (CNS 70754) in healthy adult participants.
- Trial name
- NCT07045467
- Testing
- Remimazolam Besylate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qianfoshan Hospital
End Stage Renal Disease
Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant
The study is undertaken to explore the safety of using Simulect at monthly dose intervals to reduce the need of high dose/level CNI's such as Prograf.
- Trial name
- Simulect (NCT00928811)
- Testing
- basiliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Drexel University College of Medicine