Clinical trials: Renal Transplant Recipients
Renal Transplantation
Interaction Between Rimonabant and Cyclosporine and Tacrolimus
The major cause of premature death in renal transplant recipients is cardio-vascular disease. In addition, obesity is becoming a major problem in this patient population.
- Trial name
- RIMONA-PILOT (NCT00525681)
- Testing
- cyclosporine A, tacrolimus
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- University of Oslo School of Pharmacy
Medication Adherence, Kidney Transplant
A Pilot Study of mDOT for Immunosuppressant Adherence in Adolescent Kidney Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent kidney transplant recipients.
- Trial name
- NCT03504137
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Delayed Graft Function, Kidney Transplant
Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function
The purpose of this study is to evaluate the safety and efficacy of conversion from a calcineurin inhibitor (tacrolimus or cyclosporine) immunosuppression therapy to Nulojix® (belatacept) immunosuppression therapy in patients…
- Trial name
- NCT01837043
- Testing
- Belatacept, Calcineurin Inhibitor
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nair, Vinay, D.O.
Kidney Transplant Recipients
Envarsus XR Compared to Immediate Release Tacrolimus
The purpose of this study is to compare once-daily tacrolimus extended-release (Envarsus XR®) to twice-daily immediate release tacrolimus to find out if people taking tacrolimus extended release (Envarsus XR®) report fewer side…
- Trial name
- SIMPLE (NCT03979365)
- Testing
- Envarsus XR, Tacrolimus twice daily
- Where
- 3 sites in United States
- Volunteers
- 261 people
- Sponsor
- Mayo Clinic
Kidney Transplantation, Renal Transplantation
Envarsus XR® in Adolescent Renal Transplant Recipients
Adolescents commonly experience barriers to adherence that entail forgetfulness, distraction, poor planning, and scheduling problems.
- Conditions
- Kidney Transplantation, Renal Transplantation, Grafting, Kidney
- Trial name
- EnvarsusXR (NCT03266393)
- Testing
- Envarsus XR, Tacrolimus
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Los Angeles
Non-melanoma Skin Cancer
A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin Cancer
This is a randomized, double-blind, placebo-controlled biomarker study in renal transplant recipients with actinic damage and a history of basal cell carcinomas and/or cutaneous squamous cell carcinomas.
- Trial name
- NCT03327064
- Testing
- UAB30
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Immunosuppression
Once-daily Regimen With Envarsus® to Optimize Immunosuppression Management and Outcomes in Kidney Transplant Recipients
With the availability of well-studied once-daily formulations of tacrolimus, the ability to achieve a true once-daily immunosuppressant regimen along with everolimus and steroids may finally be achievable and have the potential…
- Trial name
- NCT02954198
- Testing
- Tacrolimus, Prednisone, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Kidney Diseases, Transplant Failure
Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients
Evaluation of the frequency of APOL1 gene variants in kidney donors and the impact of these variants on the long-term renal function of kidney transplant donors and recipients.
- Trial name
- NCT06116721
- Where
- Brazil
- Volunteers
- 2,450 people
- Sponsor
- Hospital do Rim e Hipertensão
Deceased Donor Kidney Transplant, Acute Kidney Injury
Deceased Donor Biomarkers and Recipient Outcomes
Compared to chronic dialysis, kidney transplantation provides recipients with longer survival and better quality of life at a lower cost.
- Conditions
- Deceased Donor Kidney Transplant, Acute Kidney Injury, Delayed Graft Function, End Stage Renal Disease
- Trial name
- DDS (NCT01848249)
- Where
- 17 sites in United States
- Volunteers
- 1,679 people
- Sponsor
- Yale University
End Stage Renal Disease
A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients
The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER-NEXT] study will include adult kidney transplant candidates without hepatitis C virus (HCV) infection on the transplant waiting list who will consent…
- Trial name
- THINKER-NEXT (NCT04075916)
- Testing
- Epclusa
- Where
- 11 sites in United States
- Volunteers
- 201 people
- Sponsor
- University of Pennsylvania
Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection
Host Responses in Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection
Hepatitis E is a worldwide disease. It is the leading or second leading cause of acute hepatitis in adults in developing countries from sub-Saharan Africa or Southeast Asia, where it is hyperendemic and principally water-borne.
- Trial name
- NCT01090232
- Testing
- blood samples
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Renal Failure
Induction of Donor-Specific Tolerance in Recipients of Live Donor Stem Cell Infusion (Compassionate Use)
Four subjects were treated under compassionate use provisions under this study with facilitating cell therapy (FCRx)
- Trial name
- NCT02051673
- Testing
- Biological/Vaccine: Enriched Hematopoetic Stem Cell Infusion
- Where
- United States
- Sponsor
- Talaris Therapeutics Inc.
Liver Transplant, Renal Transplant
Home-Care Needs in Liver or Renal Transplantation Recipients and Their Spouses
Liver/renal transplantations are now tending to be the most important treatment for terminal liver and renal disease. Although transplantation can prevent recipients from suffering with critical and fatal symptoms, patients may…
- Trial name
- NCT01380002
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Pediatric Heart Transplantation, Immunosuppression
Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score
The TEAMMATE Trial will enroll 210 pediatric heart transplant patients from 25 centers at 6 months post-transplant and follow each patient for 2.5 years.
- Conditions
- Pediatric Heart Transplantation, Immunosuppression, Chronic Kidney Diseases, Cardiac Allograft Vasculopathy
- Trial name
- TEAMMATE (NCT03386539)
- Testing
- Everolimus, Tacrolimus, Mycophenolate Mofetil
- Where
- 25 sites in United States
- Volunteers
- 211 people
- Sponsor
- Boston Children's Hospital
Vascular Diseases, Arterial Stiffness
Relation Between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
Relation between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
- Trial name
- NCT00221533
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Ghent
Kidney Transplantation
Efficacy and Safety of Sirolimus Plus CNI Compared With MMF Plus CNI in ABO-i Kidney Transplant Recipients.
The purpose of this study is to evaluate the efficacy and safety of RaparoBell® Tablet Plus Calcineurin Inhibitors Compared with Mycophenolate Mofetil Plus Calcineurin Inhibitors in ABO incompatible De Novo Living Kidney…
- Trial name
- NCT04700709
- Testing
- Sirolimus Tab., Mycophenolate Mofetil Cap./Tab.
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Kidney Transplantation, Multiparametric Magnetic Resonance Imaging
Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing
Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy.
- Conditions
- Kidney Transplantation, Multiparametric Magnetic Resonance Imaging, Living Donors, Renal Fibrosis
- Trial name
- MpRenal (NCT06210555)
- Testing
- Renal transplantation, Living kidney donation
- Where
- 2 sites in Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Patrick Schjelderup
Renal Transplantation
Extension Study of Enteric-coated Mycophenolate Sodium With Short-term or no Steroid Use Compared With Enteric-coated Mycophenolate Sodium With Standard Steroid Therapy in de Novo Kidney Recipients
The objective of this study is to assess the long-term safety and tolerability of EC-MPS on the patients who completed the core study and wish to continue treatment on EC-MPS.
- Trial name
- NCT00240955
- Testing
- Enteric-coated Mycophenolate sodium (EC-MPS)
- Volunteers
- 79 people
- Sponsor
- Novartis
Kidney Transplantation, Antibody-mediated Rejection
CD38 mAb Induction + Azathioprine Maintenance for Chronic Active AMR in Kidney Transplant Recipients
This multicenter, prospective, single-arm exploratory study evaluates the efficacy and safety of a novel sequential regimen for chronic active antibody-mediated rejection (caABMR) in kidney transplant recipients: single-dose CD38…
- Trial name
- CAZA (NCT07718308)
- Testing
- CD38, Azathioprine (AZA), Standard Triple Immunosuppression Maintenance
- Volunteers
- 20 people
- Sponsor
- wujianyong
Renal Transplant Rejection
Calcineurin Activity in Renal Recipients
The purpose is to define if calcineurin activity is a better biological parameter than blood concentration for the therapeutic tacrolimus monitoring.
- Trial name
- NCT01413685
- Testing
- Pharmacokinetics/dynamics
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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