Clinical trials: Renal Transplant Recipients
Renal Transplantation
A Study Designed to Compare the Tolerability of an Increased Dose of Enteric-coated Mycophenolate Acid (MPA) in Renal Transplant Patients Whose Dose of Mycophenolate Mofetil (MMF) Was Reduced Due to Gastrointestinal Symptoms
To determine if conversion to enteric coated MPA allows an escalated dose of mycophenolic acid (MPA) to be tolerated in patients experiencing gastrointestinal (GI) symptoms
- Trial name
- NCT00658333
- Testing
- Enteric-coated Mycophenolate Acid (EC-MPA), Mycophenolate Mofetil (MMF)
- Where
- 37 sites in United States
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplant
Cell-mediated Immune Response to Influenza Vaccine
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT00677547
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Renal Anemia
Variability of Hemoglobin Levels After Kidney Transplantation
The purpose of this study es to determine hemoglobin variability in kidney transplant recipients with chronic renal anemia.
- Trial name
- NCT02041208
- Testing
- kidney transplantation
- Where
- 22 sites in Spain
- Volunteers
- 368 people
- Sponsor
- Sociedad Española de Trasplante
Liver Disease
Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus…
- Trial name
- NCT01958190
- Testing
- Tacrolimus and Sirolimus, Tacrolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Foundation for Liver Research
Vaccination; Infection
Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Kidney Transplant Recipients -ChronoVAX
Immune response to influenza vaccine in kidney transplant patients
- Trial name
- CHRONOVAX (NCT06088563)
- Testing
- Vaccine injection
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
HBV, Kidney Transplantation
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Solid Organ Transplantation (SOT) is made possible by the use of a lifelong immunosuppressive treatment. This treatment limits the response of the immune system, enabling long-term survival of the transplanted organ, but also…
- Conditions
- HBV, Kidney Transplantation, Liver Transplantation
- Trial name
- VITAMIN (NCT06307808)
- Testing
- Tacrolimus, Belatacept
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus Nos New Onset, Hypertrophy, Left Ventricular
New-onset Diabetes and Left Ventricular Hypertrophy in Renal Transplantation
New-onset diabetes (NODAT) after solid organ transplantation is an important clinical challenge associated to increased risk of cardiovascular (CV) events.
- Conditions
- Diabetes Mellitus Nos New Onset, Hypertrophy, Left Ventricular, Vascular Stiffness
- Trial name
- NCT01976689
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Baskent University
Immune Tolerance
Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
The study will determine whether patients with functioning Human Leukocyte Antigen (HLA) matched kidney transplants for at least one year and who want to discontinue immunosuppressive drugs can be treated with Total Lymphoid…
- Trial name
- NCT03591302
- Testing
- Hematopoietic cell transplantation, Total Lymphoid irradiation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stephan Busque
Disorder of Transplanted Kidney, Cytomegalovirus Infections
Comparison of Two Immunosuppressive Regimens in Kidney Transplant Recipients With Deceased Donors With the Aim of Preventing the Development of Fibrosis / Atrophy of Reducing the Incidence of Cytomegalovirus Infection
The aim of this the study is to the assess whether the graft and patient survival, rejection rates and renal graft function after the first year will not differ between both study arms.
- Trial name
- NCT01353053
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Federal University of São Paulo
Renal Failure
Impact of Donor-Specific Antibodies in (Highly-) Immunized Living Donor Kidney Transplant Recipients
Kidney transplantation is the preferred treatment for end-stage renal disease. Alongside limited availability of donors, rejection and premature graft loss are main barriers to kidney transplantation.
- Trial name
- NCT05431712
- Volunteers
- 252 people
- Sponsor
- Erasmus Medical Center
EBV Infections, Kidney Transplant
Safety and Tolerability of IDO-1 Inhibition in the Prevention of EBV-related Pathology in EBV Negative Kidney Transplant Recipients Receiving an Organ From EBV Positive Donors
This clinical study will evaluate the safety and tolerability of an IDO-1 inhibitor in patients receiving a kidney transplant. The study includes individuals who have not previously been infected with Epstein-Barr virus (EBV) and…
- Trial name
- IDEP (NCT07368153)
- Testing
- indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor
- Where
- 4 sites in Switzerland
- Volunteers
- 9 people
- Sponsor
- University Hospital, Basel, Switzerland
Kidney Transplantation
A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation
The purpose of this study is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of escalating doses of TCD601 when compared to rATG in de novo renal transplant patients.
- Trial name
- NCT06365437
- Testing
- TCD601, Tacrolimus (TAC), Corticosteroids (CS)
- Where
- 7 sites in Austria, Spain and 1 more
- Volunteers
- 33 people
- Sponsor
- ITB-Med LLC
Anemia
A Study Comparing Subcutaneous Mircera and Darbepoetin Alfa for Maintenance Treatment of Anemia in Kidney Transplant Recipients.
This two arm study will compare the efficacy and safety of subcutaneous Mircera versus darbepoetin alfa for the maintenance of hemoglobin levels in kidney transplant recipients with chronic renal anemia.
- Trial name
- NCT00605345
- Testing
- Darbepoetin alfa, methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 21 sites in Spain
- Volunteers
- 71 people
- Sponsor
- Hoffmann-La Roche
Immunocompromised Host, Organ Transplantation
Cancer Risk in Organ Transplant Recipients and End-Stage Renal Disease
Background: Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with an increased cancer risk because of the need for long-term immunosuppression End-stage renal disease…
- Conditions
- Immunocompromised Host, Organ Transplantation, Cancer
- Trial name
- NCT00904579
- Where
- 9 sites in United States
- Volunteers
- 19,929,901 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Kidney Disease
Pedometers to Assess and Increase Physical Activity Among Children With Chronic Kidney Disease
Hypothesis #1: Most children with CKD stages 2-4, ESRD and kidney transplantation will report participation in physical activity that falls short of recommended levels of physical activity; Children on dialysis will be less…
- Trial name
- NCT01270529
- Testing
- Increasing Physical activity
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Kidney Transplantation, Cardiovascular Diseases
Mycophenolate Mofetil for Reducing Cardiovascular Risk in Renal Transplant Recipients
The purpose of this research study is to determine if adding or increasing the dose of CellCept while lowering the dose of tacrolimus (Prograf or Advagraf) or cyclosporine (Neoral), and/or steroids can reduce the likelihood of…
- Trial name
- MMCR (NCT01213394)
- Testing
- mycophenolate mofetil, standard immunosuppression
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Ramesh Prasad
Kidney Transplant
Perceptions of Kidney Transplant Recipients Regarding the Role of Artificial Intelligence in Medicine
The AITX study is an international, multicenter survey exploring how kidney transplant recipients perceive artificial intelligence (AI) in medicine and, specifically, a system that predicts graft loss risk.
- Trial name
- AITX (NCT07600541)
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Porto-Sinusoidal Vascular Disease
Risk Factors for Portosinusoidal Vascular Disease in Kidney Transplant Recipients:
To look for the factors of exposure present prior to the onset of Porto-Sinusoidal Vascular Disease (PSVD) and which can lead to the occurrence of PSVD after renal transplantation, and therefore to consider the identification of…
- Trial name
- TRANSVAS (NCT05388409)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Kidney Transplantation, Cytomegalovirus Infections, EBV Infection
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients.
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, EBV Infection, Antiviral Prophylaxis
- Trial name
- NCT07294547
- Testing
- Valacyclovir (Valtrex), Valganciclovir (Valcyte)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
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