Clinical trials: Renal Transplantation
the Maintenance Phase After Kidney Transplantation
Specified Drug Use-results Survey of Graceptor in Patients With Kidney Transplantation (Switching From Cyclosporine)
To evaluate the safety and efficacy of Graceptor ® in patients with kidney transplantation when converted from cyclosporine
- Trial name
- NCT02160054
- Testing
- Graceptor®
- Where
- 30 sites in Japan
- Volunteers
- 289 people
- Sponsor
- Astellas Pharma Inc
Kidney Transplantation, Tuberculosis
Isoniazid Prophylaxis Based on Risk Factors of Tuberculosis in Living Kidney Transplantation Recipients
Tuberculosis (TB) is a major and severe opportunistic infection among solid organ transplant recipients. Chemoprophylaxis is advised for those with latent tuberculosis infection (LTBI).
- Conditions
- Kidney Transplantation, Tuberculosis, Isoniazid Toxicity
- Trial name
- NCT06512831
- Testing
- Isoniazid
- Where
- China
- Volunteers
- 1,348 people
- Sponsor
- West China Hospital
Renal Transplant Recipients
Calcineurin Inhibitor-Free Immunosuppression in Renal Transplant Recipients at Low Immunogenic Risk
To compare renal function (51Cr-EDTA clearance) 12 months posttransplant, in primary renal allograft recipients (from cadaveric donor) at low immunogenic risk, 0 DR mis-match, receiving immunosuppressive therapy with A) Zenapax®…
- Trial name
- NCT00138970
- Testing
- Zenapax®, CellCept® and prednisolone, Sandimmun Neoral®, CellCept® and prednisolone
- Volunteers
- 70 people
- Sponsor
- University of Oslo School of Pharmacy
End Stage Renal Disease
Pharmacokinetics of Immunosuppressants in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate how quickly and to what extent different immunosuppressants are absorbed into the blood (this is called pharmacokinetics) in renal transplant candidates who have undergone a laparoscopic…
- Trial name
- NCT02221583
- Testing
- Astagraf XL, Prograf, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Cincinnati
Hypophosphatemia, Kidney Transplantation
Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients
The primary goal is to determine if Dipyridamole can improve serum phosphate levels and reduce the need for phosphate supplementation.
- Trial name
- NCT06824454
- Testing
- Dipyridamole 75 MG
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Transplant Dysfunction
Hemodynamic Optimization During Single Kidney Transplantation With MostcareUP
There are currently no clear recommendations on hemodynamic targets during kidney transplantation and most anesthesiologists rely on empiric or obsolete parameters such as CVP.
- Trial name
- NCT03446196
- Testing
- Fluid replacement based on MOSTCARE up
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Cardiac Surgery, Cardiopulmonary Bypass
REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
- Trial name
- RETROCAR (NCT04979754)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Liver Transplant; Complications
Proteinuria in Liver Transplantation, a Single Egyptian Center Study
Proteinuria has been suggested to be a predictive factor and an important tool for differentiating the etiology of renal dysfunction in various clinical scenarios .The good predictive performance of preoperative proteinuria…
- Trial name
- NCT05733754
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Renal Failure
Immunosuppressive Effects of Mycophenolate Mofetil and Valganciclovir in Kidney Transplant Recipients
Valganciclovir (VGCV) has recently been approved by the Food and Drug Administration (FDA) for the treatment and prevention of cytomegalovirus (CMV) retinitis in HIV patients.
- Trial name
- NCT00198224
- Testing
- phlebotomy
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
Transplant; Failure, Kidney
Effects of Sevoflurane and Desflurane on Treg
This prospective interventional study aims to compare sevoflurane and desflurane anesthetic agents on regulatory T cell (Treg) numbers and its cytokine production in patients undergoing Living Donor Kidney Transplant (LDKT).
- Trial name
- NCT02559297
- Testing
- Sevoflurane, Desflurane
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Type 1 Diabetes, Kidney Transplant
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.
- Trial name
- NCT06832410
- Testing
- Biological/Vaccine
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 10 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Kidney Transplantation
NFAT-Dependent Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Patients
The purpose of this study is to compare two different ways of monitoring the immune system to determine how to manage the doses of anti-rejection medications.
- Trial name
- NCT01771705
- Testing
- Dose adjust group (NFAT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Renal Transplant
Calcineurin Inhibitor Based Immunosuppression Withdrawal
Damage and scarring of a transplanted kidney has become the most common cause of loss of the transplanted kidney. This kidney damage is a complex process caused by many factors including injury during obtaining and transplanting…
- Trial name
- CNI-W (NCT02117596)
- Testing
- Sirolimus
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Pediatric Nephrology of Alabama
Respiratory Tract Disease, Kidney Transplantation
Evaluation of the Respiratory Function in Renal Transplanted Children
Objectives: While a respiratory abnormality was found in 50% of pediatric renal transplant recipients in a study conducted in Belgium and the Netherlands in 2008, the respiratory status of transplanted children in France remains…
- Conditions
- Respiratory Tract Disease, Kidney Transplantation, Pediatric
- Trial name
- SPIROKID (NCT03571542)
- Testing
- pulmonary function
- Where
- 5 sites in France
- Volunteers
- 385 people
- Sponsor
- Nantes University Hospital
Covid19, Chronic Kidney Diseases
The REnal Patients COVID-19 VACcination Immune Response (RECOVAC IR) Study
Rationale: COVID-19 is associated with severely increased morbidity and mortality in patients with severely impaired kidney function, on dialysis or alive with a kidney transplant.
- Trial name
- RECOVAC-IR (NCT04741386)
- Testing
- SARS-CoV-2 vaccination
- Where
- 4 sites in Netherlands
- Volunteers
- 854 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
microRNA Profiles
MicroRNA Expression in Everolimus-based Versus Tacrolimus-based Regimens in Kidney Transplantation
The calcineurin inhibitor drugs including cyclosporin and tacrolimus are well-known as nephrotoxicity. However, these drugs are essential for kidney transplant especially in high immunological risks.
- Trial name
- NCT02091973
- Testing
- Everolimus, Tacrolimus
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
Kidney Transplantation
The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation
This is a long-term intervention study on the effects of marine n-3 PUFAs in renal transplantation. Our hypothesis is that patients treated with marine n-3 PUFA supplementation will have less decline in kidney transplant function…
- Trial name
- EMiRA (NCT03018041)
- Testing
- Omacor
- Where
- 6 sites in Norway
- Volunteers
- 174 people
- Sponsor
- Joe Chan
Kidney Transplant; Complications, Kidney Transplant Failure and Rejection
Prospective Pilot Feasibility Study Comparing Envarsus Once-a-day to Tacrolimus Twice-a-day Immunosuppressive Regimen on Drug Bioavailability in Hispanic First Time Kidney Transplant Recipients
This investigator-initiated post-marketing study will evaluate the role of Hispanic ethnicity on drug dosing of Envarsus in first-time stable renal transplant recipients.
- Trial name
- NCT03438773
- Testing
- Envarsus, Tacrolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- California Institute of Renal Research
Kidney Transplantation
Asian Study to Investigate Safety and Efficacy of Optimized Dosing of Advagraf in Kidney Transplantation
Primary purpose of this study is to compare renal function between subjects receiving optimized dose Advagraf® over 52 weeks after kidney transplantation and subjects receiving standard dose Advagraf®.
- Trial name
- OPTIMIZE (NCT02161237)
- Testing
- Advagraf®
- Where
- 2 sites in South Korea, Taiwan
- Volunteers
- 73 people
- Sponsor
- Astellas Pharma Inc
Kidney Transplant, Depression
Collaborative Care Intervention for Chronic Kidney Disease
The aims of the present study will be to pilot test the efficacy of a collaborative care intervention in patients awaiting kidney transplant to reduce symptoms of depression, pain, fatigue and improve quality of life.
- Conditions
- Kidney Transplant, Depression, Pain
- Trial name
- NCT02938351
- Testing
- Collaborative care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh