Clinical trials: Renin Angiotensin Aldosterone System
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Renin-Angiotensin System
The Effect of RAAS Blockers on ACE2 Levels
Blockage of renin-angiotensin-aldosterone system (RAAS) by angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) is considered the first-choice of drugs for treatment of hypertension, heart…
- Trial name
- NCT05418361
- Testing
- ACE inhibitor ,angiotensin receptor blockers
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Salt Sensitivity of Blood Pressure, High Blood Pressure
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans
Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease.
- Conditions
- Salt Sensitivity of Blood Pressure, High Blood Pressure, Inflammation, Renin-Angiotensin-Aldosterone System
- Trial name
- NCT07602166
- Testing
- 2-hydroxybenzylamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Rehabilitation
Prognosis Predictors for Heart Failure
This study is looking for the predictors of the survival or rehospitalization of patients with heart failure with reduced ejection fraction. Participants who are discharged from an acute heart failure hospitalization are enrolled.
- Conditions
- Heart Failure, Rehabilitation, Morality, Hospitalization
- Trial name
- NCT04838470
- Testing
- cardiac rehabilitation
- Volunteers
- 792 people
- Sponsor
- Chang Gung Memorial Hospital
Hypertension, Stress, Psychological
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress
High blood pressure, or hypertension, is a serious problem in the African-American (AA) population which affects nearly 7 of every 10 AAs in our area.
- Conditions
- Hypertension, Stress, Psychological, Blood Pressure
- Trial name
- NCT02431936
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Heart Failure, Ischemic Cardiomyopathy
Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction
Chronic heart failure represents an extremely complex clinical syndrome, defined as the inability of the heart muscle to generate a volume adequate to the metabolic needs of peripheral tissues, or to do so only in the face of…
- Trial name
- HFrEF (NCT05745571)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Microalbuminuria, Macroalbuminuric Diabetic Nephropathy
Triple Blockade of the Renin Angiotensin Aldosterone System in Diabetic (Type 1&2) Proteinuric Patients
Study Hypothesis: Reduction in albuminuria has been shown to decrease progression of diabetic nephropathy. In diabetic nephropathy patients treated with maximal antihypertensive doses with dual RAAS blockade (total daily dose…
- Conditions
- Microalbuminuria, Macroalbuminuric Diabetic Nephropathy, Diabetes, Proteinuria
- Trial name
- NCT00961207
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cook County Health
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Metabolic Syndrome
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs glycemic control via effects on insulin sensitivity and insulin secretion. Aim 2.
- Trial name
- NCT02034435
- Testing
- Low Sodium diet plus Salt tablet, Epleronone, Amlodipine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Hyperkalemia
Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
The purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.
- Trial name
- DIAMOND (NCT03888066)
- Testing
- Patiromer
- Where
- 415 sites in United States, Argentina and 19 more
- Volunteers
- 1,195 people
- Sponsor
- Vifor Pharma, Inc.
Myocardial Infarction
Effect of Renin Angiotensin Aldosterone System Genetic Polymorphism on the Pharmacological Effect of Mineralocorticoid Receptor Antagonists in Patients With Myocardial Infarction
Early treatment of Myocardial Infarction patients with mineralocorticoid receptor antagonist with help reduces the incidence of cardiac remodeling and development into heart failure.
- Trial name
- NCT05873400
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
PreDiabetes, Impaired Glucose Tolerance
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
The primary objective is to examine the impact of the Renin-Angiotensin-Aldosterone System (RAAS) blockade with medications (valsartan) or RAAS and neprilysin inhibition (valsartan/sacubitril) vs.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Obesity, Blood Pressure
- Trial name
- NCT03938389
- Testing
- Sacubitril-Valsartan Tab 97-103 MG, Valsartan 160mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Tetralogy of Fallot, Heart Defects, Congenital
Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone System
Rationale: The prevalence of adult patients with congenital heart disease (CHD) has steadily increased over the last decades, due to the advances in cardiac surgery.
- Conditions
- Tetralogy of Fallot, Heart Defects, Congenital, Ventricular Dysfunction, Right
- Trial name
- Redefine (NCT02010905)
- Testing
- Losartan
- Where
- 6 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
HIV-infection
Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV
The purpose of this study is to see if individuals with HIV-infection, particularly those with increased belly fat, have abnormalities in the renin angiotensin aldosterone axis.
- Trial name
- NCT01407237
- Testing
- Angiotensin II Infusion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Radiographic Contrast Agent Nephropathy
Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced Nephropathy
The aim of the current study is to evaluate prospectively whether concomitant administration of renin-angiotensin-aldosterone system (RAAS) blockers (namely ACE-I and ARBs') influence the change in estimated glomerular filtration…
- Trial name
- NCT01525888
- Testing
- stop angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACE-I/ARB)
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Acute Decompensated Heart Failure
RAAS Optimization for Acute CHF Patients
Holding ACEI/ARBs during initial 72 hours of admission with acute decompensated heart failure may help preserve renal function with a lesser decline in GFR.
- Trial name
- ROAD-HF (NCT03695120)
- Testing
- Change of treatment plan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study A
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD A (NCT00283686)
- Testing
- Lisinopril, Telmisartan, Standard Blood Pressure Control
- Where
- 7 sites in United States
- Volunteers
- 558 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Cardiovascular Diseases
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death.
- Conditions
- Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure
- Trial name
- PRECISION-BP (NCT04971720)
- Testing
- Sacubitril-Valsartan 49 Mg-51 Mg Oral Tablet, Valsartan 80 mg Oral Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham