Clinical trials: Renin Hypertension
Hypertension, Metabolic Syndrome
The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome
Study purpose: African Americans with hypertension and markers of metabolic syndrome (small elevations in blood glucose, triglycerides and or weight) are at a high risk of cardiovascular (heart and blood vessel) problems.
- Trial name
- SAAVE (NCT01432106)
- Testing
- Aliskerin/Valsartan and Rampiril
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Hypertension, Plasma Renin Activity
A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension
The purpose of this study is to investigate the effect of plasma renin activity-guided therapy for determining hypertension treatment.
- Trial name
- NCT01658657
- Testing
- Hydrochlorothiazide, Lisinopril, Amlodipine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension, Resistant to Conventional Therapy
Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China
Recent studies indicate that primary aldosteronism (PA) is a much more common cause of hypertension than had been demonstrated historically.
- Trial name
- NCT01459042
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cardiovascular Diseases, Heart Diseases
Hypertensive and Normal Pregnancy--Calcium Metabolism and Renin-Angiotensin - SCOR in Hypertension
To study calcium metabolism and the renin-angiotensin system in hypertensive and normal pregnancy.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Eclampsia
- Trial name
- NCT00005456
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
The purpose of this study is to compare the impact of two blood pressure lowering treatments (high dose quinapril versus low dose quinapril plus amlodipine) on variations in heart rate over 24 hours.
- Trial name
- NCT00313547
- Testing
- Quinapril 40 mg, Quinapril 10 mg and amlodipine 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Hypertension
New Biomarkers and Difficult-to-treat Hypertension
The purpose of this study is to determine the concentrations and variabilities of urinary exosomal sodium channels and plasma angiotensins in patients with difficult-to-treat arterial hypertension and to investigate their…
- Trial name
- NCT03034265
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension, Vitamin D Deficiency
Effect of Vitamin D Replacement During Winter Months in Patients With Hypertension
High blood pressure is related to increased risk of cardiovascular disease and death, and accounts for approximately 8 mill deaths worldwide each year.
- Trial name
- NCT01166165
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 136 people
- Sponsor
- Regional Hospital Holstebro
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study B
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD B (NCT01885559)
- Testing
- Lisinopril, Telmisartan
- Where
- 7 sites in United States
- Volunteers
- 486 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypertension
Effect of Light Meal on Pharmacokinetic and Pharmacodynamics of Aliskiren in Patients With Mild to Moderate Hypertension
The purpose of this study is to determine the effect of a light meal on the pharmacokinetics and pharmacodynamics of aliskiren in patients with mild to moderate hypertension.
- Trial name
- NCT00933920
- Testing
- Aliskiren
- Where
- 5 sites in India
- Volunteers
- 124 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Phase IIa Safety and Efficacy Study of SPP635 in Mild to Moderate Hypertension
This study is conducted to investigate the effect of the oral renin inhibitor SPP635 on blood pressure in patients with mild to moderate hypertension.
- Trial name
- NCT00376636
- Testing
- SPP635 (drug)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Speedel Pharma Ltd.
Hypertension, COVID-19
Coronavirus (COVID-19) ACEi/ARB Investigation
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- CORONACION (NCT04330300)
- Testing
- Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor
- Where
- Ireland
- Volunteers
- 2,414 people
- Sponsor
- National University of Ireland, Galway, Ireland
Hyperkalemia
Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
The purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.
- Trial name
- DIAMOND (NCT03888066)
- Testing
- Patiromer
- Where
- 415 sites in United States, Argentina and 19 more
- Volunteers
- 1,195 people
- Sponsor
- Vifor Pharma, Inc.
Salt Sensitivity of Blood Pressure, High Blood Pressure
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans
Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease.
- Conditions
- Salt Sensitivity of Blood Pressure, High Blood Pressure, Inflammation, Renin-Angiotensin-Aldosterone System
- Trial name
- NCT07602166
- Testing
- 2-hydroxybenzylamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension
Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study
The purpose of this study is to develop an approach to provide personalized medicine to individuals who have hypertension (high blood pressure).
- Trial name
- NCT01009944
- Testing
- Lisinopril, Atenolol
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Hypertension
RAS Peptide Profiles in Patients With Treatment-resistant Arterial Hypertension
This study evaluates RAS peptides profiles in patients with treatment resistant arterial hypertension.
- Trial name
- NCT02962778
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
COVID-19, Hypertension
Renin-Angiotensin System Inhibitors and COVID-19
Multicentric non-profit observational study, in patients with COVID-19 hospitalized in Italy, conducted through a pseudonymised survey.
- Conditions
- COVID-19, Hypertension, Cardiovascular Diseases
- Trial name
- SARS-RAS (NCT04331574)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Societa Italiana dell'Ipertensione Arteriosa
Hypertension
Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients
This study is designed as a mechanistic study to compare the effect of two different combinations of anti-hypertensive treatments (aliskiren and valsartan vs.
- Trial name
- NCT00939588
- Testing
- Aliskiren/ Valsartan, Telmisartan/ Ramipril
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension, Vitamin D Deficiency
Effects of Vitamin D on Renin Expression in Hypertensive Patients
The cardiovascular effects of vitamin D therapy (in humans) have been documented only in patients with known vitamin D deficiency or hyperparathyroidism (a surrogate marker of inadequate vitamin D activity).
- Trial name
- NCT00585442
- Testing
- calcitriol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Hypertension
Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential Hypertension
Assessing efficacy, safety and pharmacokinetics in patients with mild to moderate essential hypertension
- Trial name
- NCT00344110
- Testing
- Aliskiren
- Where
- Japan
- Volunteers
- 768 people
- Sponsor
- Novartis