Clinical trials: Replacement, Knee
Arthroplasty, Replacement, Knee
Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
The primary aim of this pilot study will be to develop a clinically meaningful, patient-centric, and pragmatic protocol to evaluate the comparative effectiveness of different strategies for achievement of the ideal balance…
- Trial name
- NCT02773537
- Testing
- Femoral nerve catheter and sciatic nerve block, Adductor canal catheter and selective tibial block, Adductor canal catheter only
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Medical University of South Carolina
Acute Postoperative Pain
Study Assessing Pain Relief After Replacement of the Knee
This is a Phase 2B randomized, double blind, active controlled, multi-center clinical trial to evaluate the safety and efficacy of ATX-101 in participants following total knee arthroplasty.
- Trial name
- SPARK (NCT05260008)
- Testing
- ATX-101, bupivacaine hydrochloride without epinephrine
- Where
- 13 sites in Australia, Canada and 1 more
- Volunteers
- 112 people
- Sponsor
- Allay Therapeutics, Inc.
Venous Thromboembolism
Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement
The main purpose of this study is to determine if an investigational medication called SelK2 works in preventing a condition called "venous thromboembolism" (VTE) in patients having a total knee replacement.
- Trial name
- COURSE (NCT03812328)
- Testing
- SelK2, Enoxaparin
- Where
- 21 sites in Bulgaria, Latvia and 3 more
- Volunteers
- 207 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
Arthroplasties, Knee Replacement
A Trial of Mechanical Axis vs Kinematic Alignment in Total Knee Replacement
This is a prospective, randomized, longitudinal study of the clinical outcomes of osteoarthritis patients treated by two different alignment philosophies for total knee replacement.
- Trial name
- NCT02527148
- Testing
- OtisMed® ShapeMatch® Technology, Stryker Precision Knee Navigation, Total Knee Replacement
- Volunteers
- 100 people
- Sponsor
- Stryker South Pacific
Knee Osteoarthritis
Total Knee Arthroplasty: Functional and Clinical Outcomes
The purpose of this study is to assess the differences in functional and patient reported outcomes between total knee replacement (TKA) implants.
- Trial name
- NCT01811563
- Testing
- Zimmer, Stryker
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Post-operative Pain
Genicular Nerve Block for Total Knee Arthroplasty
This study seeks to examine the analgesic efficacy of genicular nerve blocks for pain after total knee replacement.
- Trial name
- NCT03706313
- Testing
- 15mL 0.25% bupivacaine, Genicular nerve block, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Difference Between Femoral Nerve Block and Saphenous Block
Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural to provide long-lasting pain relief with or without a femoral nerve block (FNB).
- Trial name
- NCT01505374
- Testing
- Study Technique, Control Technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery
The investigators are testing the hypothesis that administering 2L of body temperature warmed lactated ringer's intravenously prior to surgery can optimize the postoperative and recovery of patients undergoing total hip and total…
- Trial name
- Hydration (NCT02638623)
- Testing
- Lactated Ringer
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Total Knee Replacement
Evaluation of Patellar Crepitus Following Total Knee Arthroplasty
Analyze clinical data for a group of subjects implanted with a new surgical device designed to reduce the incidence of patellar crepitus following PCL-substituting TKA and compare that to a control group of subjects implanted…
- Trial name
- NCT01340144
- Volunteers
- 1,250 people
- Sponsor
- Colorado Joint Replacement
Knee Arthroplasty, Postoperative Pain
Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
This study is conducted to evaluate the effectiveness and safety of ketamine infusion for pain relief after knee replacement surgery.
- Conditions
- Knee Arthroplasty, Postoperative Pain, Pain Management, Analgesia
- Trial name
- KETARTHRO (NCT07059429)
- Testing
- Ketamine, Standard Analgesia
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Primary Osteoarthritis of Knee Nos
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement
The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee replacement, and 2) whether…
- Trial name
- NCT01850394
- Testing
- Tranexamic Acid, Physiologic saline
- Where
- Thailand
- Volunteers
- 152 people
- Sponsor
- Mahidol University
Arthroplasty, Replacement, Knee
ShapeMatch Cutting Guide Functional Outcomes Study
Randomized evaluation of the ShapeMatch Cutting Guide for primary total knee replacement (TKR) in a consecutive series of patients who meet the eligibility criteria.
- Trial name
- ShapeMatch (NCT02539992)
- Testing
- Triathlon® CR/Kinematic Alignment, Triathlon® CR/Neutral Overall Limb Alignment, Triathlon® CR/Conventional Limb Alignment
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 44 people
- Sponsor
- Stryker Orthopaedics
Knee Prosthesis, Knee Replacement Arthroplasty
Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA
Utilize previously developed mathematical model to determine in vivo knee mechanics (kinematics, forces, stresses, areas and sound) for subjects having a Sigma Posterior Stabilizing (PS) mobile bearing (MB) total knee…
- Trial name
- Sigma MB TKA (NCT01714492)
- Testing
- Sigma Posterior Stabilizing Rotating Platform TKA Beaded Poly
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis
Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study
The primary objective of this investigation is to compare the precision of long leg alignment achieved by the two types of procedure.
- Trial name
- NCT00733330
- Testing
- Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 86 people
- Sponsor
- DePuy International
Knee Arthroplasty, Total
iTotal Pilot Study of ConforMIS Custom Total Knee Implant
To compare the outcomes of patients receiving the ConforMIS custom total knee implant to the outcomes of patients who receiving an off-the-shelf total knee implant.
- Trial name
- NCT02186587
- Testing
- ConforMIS custom total knee
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Missouri-Columbia
Opioid Use, Pain, Post Operative
A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Opioid addiction in post-operative patients is recognized but not fully understood; therefore, in order to address this growing crisis, it is essential to explore alternative approaches to managing pain and apply them to the…
- Trial name
- NCT05252858
- Testing
- nCAP Signal Relief Patch, Standard of Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Jacques E. Chelly
Total Knee Arthroplasty(TKA), Total Knee Replacement
Flexion Versus Extension Soft Tissue Repair in Total Knee Arthroplasty
The purpose of the present study is to determine the influence of position of soft tissue repair (flexion versus extension) in post operative range of motion(ROM) and functional outcome in patients who underwent primary total…
- Trial name
- NCT02067533
- Testing
- soft tissue repair in flexion position, soft tissue repair in extension position
- Where
- Iran
- Volunteers
- 91 people
- Sponsor
- Isfahan University of Medical Sciences
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC