Clinical trials: Replacement, Total Knee
OsteoArthritis Knee
A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthroplasty, A Randomized Controlled Study
The goal of this randomized controlled study is to investigate the Efficacy of Using skin adhesive (Dermabond) and skin adhesive with polyester mesh (Dermabond Prineo )for Wound Closure in Total Knee Arthroplasty, The main…
- Trial name
- NCT06232018
- Testing
- Skin adhesive (Dermabond), skin adhesive + polyester mesh (Dermabond prineo)
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pooriwat Lertsurawat
Osteoarthritis
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty
The purpose of this study is to determine whether local infiltration analgesia is more effective than intrathecal morphine in reducing postoperative pain in total knee arthroplasty.
- Trial name
- NCT00992082
- Testing
- ropivacaine, ketorolac and epinephrine, morphine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Knee Osteoarthritis
Porous Baseplate in Total Knee Replacement
This is a multi-centre single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Advance Porous fixed bearing tibial baseplate and compatible femoral, patellar, and bearing components.
- Trial name
- NCT05226689
- Testing
- POROUS TIBIA BASEPLATE W/ JRNY LOCK
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Total Knee Replacement
Effects of Combined Topical and Systemic Steroid Administrations on Better Early Postoperative Pain Management in Total Knee Arthroplasty
With the aging of population, osteoarthritis of knees and hips has become major orthopaedic problems in Hong Kong. Osteoarthritis of knees and hips is associated with significant pain problems and functional disability.
- Trial name
- NCT03901768
- Testing
- Dexamethasone, Triamcinolone
- Where
- Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Total Knee Arthroplasty Revision, Inflammatory Markers
Fiber Smoothie Supplement
This study aims to assess the feasibility of a 2-week dietary whole-food smoothie intervention and compare outcomes between two groups: patients that integrated a daily whole food plant-based smoothie into their diet for two…
- Conditions
- Total Knee Arthroplasty Revision, Inflammatory Markers, Gut Microbiota
- Trial name
- NCT06896240
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
Neuropathic Pain
The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA).
- Trial name
- NCT05581836
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- The Catholic University of Korea
Chronic Knee Pain
Radiofrequency Ablation After Total Knee Arthroplasty
The purpose of this study is to assess how clinically useful and safe genicular nerve radiofrequency ablation is in people with chronic pain after total knee arthroplasty performed for osteoarthritis.
- Trial name
- RACKTKA (NCT05473663)
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Massachusetts, Worcester
Postoperative Pain Management in Total Knee Arthroplasty
Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management
This randomized controlled trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) when performed in combination with intermittent adductor canal block (iACB) and posterior capsule local…
- Trial name
- NCT07191964
- Testing
- Supra-Sartorial Subcutaneous Infiltration (SSSI), intermittent adductor canal block (iACB), posterior capsule local infiltration analgesia (PC-LIA)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Medical University WanFang Hospital
Knee Osteoarthritis
Minimally Invasive Knee Replacement Outcomes (MIKRO) Study
The purpose of this study is to evaluate and compare the clinical, radiographic (x-ray) and cost effectiveness outcomes (cost relative to risks and benefits) of two different minimally invasive knee joint replacement surgical…
- Trial name
- MIKRO (NCT00633113)
- Testing
- MPPA, SV
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Blood Loss Anemia, Osteoarthritis, Knee
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
- Trial name
- NCT01370460
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Henry Ford Health System
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Total Knee Arthroplasty, Ischemic Preconditioning
Ischemic Preconditioning in Total Knee Arthroplasty
The application of a tourniquet for 5 minutes and subsequent reperfusion before actual inflation of the tourniquet for total knee arthroplasty (ischemic preconditioning) decreases the level of local inflammation and therefore…
- Conditions
- Total Knee Arthroplasty, Ischemic Preconditioning, Postoperative Pain
- Trial name
- NCT01333969
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Deep Vein Thrombosis, Venous
Rosuvastatin for Preventing Deep Vein Thrombosis
Deep vein thrombosis (DVT)is devastating disease which influencing the mortality and morbidity of patients at-risk like those undergoing orthopedic surgery.
- Conditions
- Deep Vein Thrombosis, Venous, Thrombosis, Prevention
- Trial name
- STOP-DVT (NCT01021488)
- Testing
- Rosuvastatin 20mg/d for 14days, enoxaparin only
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Hallym University Medical Center
Total Knee Arthroplasty
Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）
This is a randomized, double-blind, active-controlled, multicenter, phase II clinical study designed to evaluate the efficacy and safety of BT-114143 Injection in the perioperative treatment of unilateral total knee arthroplasty.
- Trial name
- TKA (NCT07127042)
- Testing
- Low-dose BT-114143, High-dose BT-14143, Tranexamic Acid (IV)
- Where
- China
- Volunteers
- 270 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Total Knee Arthroplasty
Swelling Management After Total Knee Arthroplasty
The purpose of this feasibility study is to estimate the initial efficacy and feasibility of an inelastic compression garment donned immediately after TKA on peak swelling in 14 subjects.
- Trial name
- NCT04841356
- Testing
- Immediate Compression Garment
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Knee Arthroplasty, Knee Arthroplasty, Total
Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
To evaluate the progression on patients suffering from end stage OA whilst being on the waiting list for TKR
- Conditions
- Knee Arthroplasty, Knee Arthroplasty, Total, Knee Replacement, Total, Replacement, Total Knee
- Trial name
- TKA HRQoL (NCT03492320)
- Testing
- Health Quality of Life Questionnaire Assessment
- Volunteers
- 127 people
- Sponsor
- Dr. Ho Ki Wai
Hip or Knee Replacement
'M'-Technique, Guided Imagery, or Standard of Care on Anxiety and Pain Pre- & Post-operatively in Elective Joint Replacement Patients
In the M-TIJRP protocol the investigators will utilize two Integrative Medicine modalities in a randomized, controlled study using either the 'M'-Technique® developed by Jane Buckle, PhD or Diane L.
- Trial name
- M•TIJRP (NCT01874379)
- Testing
- 'M'-Technique®, Guided Imagery, Standard of Care
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Saint Clare's Health System
Total Knee Replacement
Clinical and Functional Outcome of the Gemini SL Fixed Bearing at Midterm Follow-up
This is a retrospective, multicenter case series with a prospective follow-up to confirm the safety and performance of the Gemini SL Fixed Bearing knee prosthesis in midterm follow-up under routine conditions.
- Trial name
- NCT03575546
- Where
- 3 sites in Germany, Spain
- Volunteers
- 254 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Osteoarthritis, Knee
The Comparison of Anterior Knee Pain in Patella With or Without Denervation in Medial Unicompartmental Knee Arthroplasty
the present study will conduct to assess anterior knee pain and complications after medial UKA with or without patella denervation in medial compartment arthritis and severe lateral facet patellofemoral arthritis patients.
- Trial name
- NCT03676179
- Testing
- patella denervation, patella non-denervation
- Where
- Thailand
- Volunteers
- 66 people
- Sponsor
- Ramathibodi Hospital