Clinical trials: Replacement, Total Knee
Intraoperative Bleeding, Post-operative Bleeding
Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR
The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.
- Trial name
- NCT01891461
- Testing
- Floseal
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery
This study will prospectively investigate the efficacy of Adductor canal block with periarticular infiltration Vs Adductor canal block, Periarticluar infiltration and Sensory posterior articular nerve of the knee block in…
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
- Trial name
- NCT04290442
- Testing
- adductor canal block, SPANK, Ropivacaine
- Where
- United States
- Sponsor
- Bruce Ben-David
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Knee Osteoarthritis, Total Knee Replacement
The Effect of Laser Acupuncture Intervention to the Prognosis After TKR Surgery
This study protocol is mainly focus on the patients, who suffer pain, swelling, or range of motion limitation after total knee replacement (TKR) surgery procedure,would be relieved by use non-invasive laser acupuncture to stimuli…
- Trial name
- NCT05263856
- Testing
- laser acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis
Efficacy Study of Pre-emptive Etoricoxib for Postoperative Pain and Functional Outcome in Total Knee Arthroplasty
The purpose of this study is to study the efficacy of pre-emptive etoricoxib in reducing post-operative pain and improving function outcome after a total knee arthroplasty.
- Trial name
- NCT01246362
- Testing
- Control, Etoricoxib
- Where
- Singapore
- Volunteers
- 65 people
- Sponsor
- Singapore General Hospital
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
TKA, THA
Binaural Beats for Postoperative Pain and Anxiety Reduction
To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee…
- Conditions
- TKA, THA, Anxiety, Binaural Beats
- Trial name
- NCT07437469
- Testing
- Binaural Beats Audio Intervention, Music of Choice
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Joint Arthroplasty, Knee and Hip
Functional Predictive Value of Collective Outcome Measure(s) Status Post Total Hip/Knee Arthroplasty
Researchers are trying to assess a predictive value or correlation of outcome measures results on subjects following a total knee or total hip arthroplasty in order to better predict the time frame taken to achieve certain…
- Trial name
- NCT03933969
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mayo Clinic
Anticoagulation
Multi-center Study to Evaluate the Safety of Apixaban (BMS-562247) in Indian Subjects Undergoing Elective Total Knee Replacement or Total Hip Replacement Surgery
The primary purpose of this protocol is to evaluate the safety of Apixaban in prophylaxis of Venous Thromboembolism (VTE) in Indian patients undergoing elective total knee or hip replacement
- Trial name
- NCT01884337
- Testing
- Apixaban
- Where
- 20 sites in India
- Volunteers
- 557 people
- Sponsor
- Bristol-Myers Squibb
Knee Osteoarthritis
A Quantitative Assessment of Early Mobility in Total Knee Replacement Patients Using Smart Activity Tracker
This study aims to evaluate the patients' mobility and quality of life prior to their total knee replacement surgery and their progress pre-operatively and 6 months post-operatively using the smart activity tracker.
- Trial name
- Geospatial (NCT05076539)
- Testing
- Garmin GPS activity tracker
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Surgery, Knee Osteoarthritis
Bypass PACU in Knee and Hip Arthroplasty
A Quality Study in the use of Post-Anaesthesia Care Unit(PACU) in Hip and Knee Arthroplasty, and the ability to bypass this unit.
- Conditions
- Surgery, Knee Osteoarthritis, Postoperative Complications, Hip Osteoarthritis
- Trial name
- NCT03984942
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Niklas Ingemann Nielsen
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
CRPS
Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
The Department of Anesthesiology is conducting a clinical trial to evaluate if pregabalin given prior to and for several days after Total Knee Arthroplasty (TKA) will reduce the prevalence of Complex Regional Pain Syndrome (CRPS)…
- Trial name
- PregTKA (NCT00558753)
- Testing
- pregabalin
- Volunteers
- 240 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
Prehabilitation Using Aquatic Exercise
With aging population, total knee arthroplasty is performed with increasing frequency. Although the surgery is successful in general, significant number of patients suffers persistent pain and disability.
- Trial name
- NCT02773745
- Testing
- Aquatic Prehab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Knee Arthritis Osteoarthritis, Cruciate Ligament Rupture
A Retrospective and Prospective Study: Monocompartimental Knee Arthroplasty Combined With Anterior Cruciate Ligament Reconstruction Surgery - a Pilot Study
This study aims to collect datas about patient who underwent simultaneous monocompartimental knee replacement and anterior cruciate ligament recontruction
- Trial name
- MONO-LCA (NCT07377669)
- Testing
- UKA + ACLr
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Use of Tourniquet in Total Knee Arthroplasty
Effects of the Use of Tourniquet in Total Knee Arthroplasty on the Clinical and Functional Outcomes With 5 Years of Follow up
This study is randomized controlled trial with 5 years follow up and involved 101 patients divided in two groups; group A in which tourniquet was used in total knee arthroplasty while group B in which tourniquet was not used.
- Trial name
- NCT04469166
- Testing
- tourniquet, No tourniquet
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis
Dietary Supplementation With Blueberry in OA
Osteoarthritis is a painful long term joint condition that is associated with poor quality of life. There are no treatments to prevent it. Inflammation is one cause of osteoarthritis. This inflammation is complex.
- Trial name
- NCT05784545
- Testing
- Blueberry powder supplement, Maltodextrin supplementation
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Exeter
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to…
- Conditions
- Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee, Anesthesia, Local
- Trial name
- NCT07337772
- Testing
- LIA with different doses of Diprospan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University