Clinical trials: Replacement, Total Knee
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Arthropathy of Knee
Economic and Functional Impact of Peri-Operative Bracing for Primary Total Knee Arthroplasty (TKA)
While bracing has been shown to be beneficial for patients with osteoarthritis (OA) in terms of function and strength, whether these unloader braces are also similarly beneficial after total knee arthroplasty (TKA) surgery needs…
- Trial name
- NCT03260699
- Testing
- OCSI Rehabilitator brace
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Arthroplasty, Replacement
Triathlon Tritanium Cone Augments Outcomes Study
The purpose of this study was to evaluate the success rate of the Triathlon Tritanium Cone Augment with the Triathlon TS Total Knee System at 2 years postoperative, defined as absence of revision of the Femoral Cone Augment or…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT02521103
- Testing
- Triathlon Tritanium Cone Augments
- Where
- 9 sites in United States
- Volunteers
- 254 people
- Sponsor
- Stryker Orthopaedics
Total Knee Arthroplasty
Comparison of Intraoperative Warming Devices
The sublingual (under the tongue) core temperature within 10 minutes of arrival in the post anesthesia care unit (PACU) for patients warmed with the Dynatherm vitalHeat2 (VH2) System under general anesthesia for total knee…
- Trial name
- NCT00711867
- Testing
- VH2, Bair Hugger
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Knee Rheumatism
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
One common anesthetic that is performed for total knee replacement surgery is spinal anesthesia with an adductor canal regional block, which involves injecting numbing medication in the thigh region for pain control after…
- Trial name
- NCT03326999
- Testing
- Obturator nerve regional block, Adductor canal regional block, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Arthritis
Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement
You are invited to participate in a research study assessing your mental status in the first days after your surgery and how you will be doing in the 2 years following the surgery.
- Trial name
- NCT01270620
- Testing
- propofol, Desflurane
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pedro Paulo Tanaka
Knee Osteoarthritis
Comparison of High Flex and Standard Rotating Platform Total Knee Arthroplasty (TKA)
The goal of this study is to determine if the rotating platform high flex design provides improved flexion compared to the standard rotating platform TKA.
- Trial name
- NCT01176292
- Testing
- Rotating Platform High-Flex Cruciate Substituting TKA, Rotating Platform Cruciate Substituting TKA
- Volunteers
- 142 people
- Sponsor
- Anderson Orthopaedic Research Institute
Pain, Total Knee Replacement
Predicting, Understanding and Speeding Recovery After TKA
The objective of this research study is to better understand patterns of recovery after Total Knee Arthroplasty (TKA) amd Total Hip Replacement (THA).
- Conditions
- Pain, Total Knee Replacement, Total Hip Replacement
- Trial name
- NCT02685735
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Wake Forest University Health Sciences
Total Knee Arthroplasty, Osteo Arthritis Knee
In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
In vivo knee kinematics will be assessed for 20 subjects that have been implanted with a Total Joint Orthopedics Klassic knee system by Dr.
- Conditions
- Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
- Trial name
- TKA (NCT04113785)
- Testing
- Klassic Knee System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Tennessee, Knoxville
Postoperative Urinary Retention, Total Hip Arthroplasty
RCT Foley Catheter Study for Elective TJA
Urinary retention is a known complication following surgical procedures, with a theoretical increased risk in patients receiving neuraxial anesthesia due to a decreased ability to sense bladder distension.
- Conditions
- Postoperative Urinary Retention, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- NCT05428020
- Testing
- Indwelling foley catheter, No foley catheter
- Where
- United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy of the 220 mg dose Pradaxa to generate additional data in predefined sub populations of patients at increased risk of bleeding or VTE
- Trial name
- NCT00846807
- Where
- 112 sites in Austria, France and 7 more
- Volunteers
- 5,476 people
- Sponsor
- Boehringer Ingelheim
Total Hip and Knee Arthroplasty
A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty
This study evaluates two routinely used drug combinations for periarticular injection following total hip and knee arthroplasty for pain control.
- Trial name
- NCT02543801
- Testing
- Liposomal Bupivacaine, Ropivacaine, Bupivacaine
- Volunteers
- 239 people
- Sponsor
- Kootenai Health
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Dose Dependent Effects of tDCS on Post-Operative Pain
The proper control of acute and chronic pain is one of the most important areas in health care. Despite the profound advances in neuroscience over the past 20 years, the investigators still largely use opiate narcotics, much as…
- Trial name
- tDCS-TKA (NCT02241967)
- Testing
- 4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Arthroplasty, Replacement, Knee
Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj
This study seeks to determine whether a new sustained-release local anesthetic solution (Exparel - Liposomal Bupivacaine) injected into the soft tissues around the joint after surgery will decrease opioid consumption and adverse…
- Trial name
- NCT02682498
- Testing
- (Bupivacaine Liposome Injectable Suspension), Standard Preparation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, Irvine
Knee Prosthesis, Knee Arthroplasty
Comparison of Kinematics for Subjects Implanted With a PFC Sigma Rotating Platform or Fixed Bearing TC3 Prosthesis
The objectives of this study are four-fold: 1. To determine the three-dimensional, in vivo kinematics for subjects having either a fixed- or mobile-bearing Press Fit Condylar (PFC) Sigma Total Condylar III Prosthesis, comparing…
- Trial name
- PFC & TC3 (NCT01290640)
- Testing
- DePuy fixed-bearing Total Condylar III (TC3) TKA, DePuy PFC Rotating Platform TC3 TKA
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- The University of Tennessee, Knoxville
Obstructive Sleep Apnea (OSA)
Effects of Audiovisual Distraction on Desaturation and Airway Intervention in OSA-patients
Patients will be randomly assigned to either one of two groups: 1. Standard of care sedation 2. Audiovisual distraction during surgery and in the recovery room using video goggles and headphones; patients can choose a movie from…
- Trial name
- AVD (NCT03020914)
- Testing
- Audiovisual Distraction
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
PAIN
Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement
This study involves research. Pregabalin is a Food and Drug Administration (FDA) medication approved in the United States for the treatment of nerve pain related to diabetes and post-herpetic neuralgia "shingles", and for…
- Trial name
- NCT00729690
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Asokumar Buvanendran
Arthroplasty, Replacement, Knee, Pain, Postoperative
Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) can be associated with a large amount of postoperative pain. This pain can oftentimes be severe enough to limit participation in physical therapy and ultimately delay discharge resulting in increased…
- Trial name
- NCT02453360
- Testing
- Adductor Canal Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Total Knee Arthroplasty, Opioid Use
Dronabinol in Total Knee Arthroplasty (TKA)
The goal of this double-blinded randomized controlled trial is to compare whether the addition of Dronabinol compared to a placebo will affect opioid intake in patients undergoing a total knee arthroplasty.
- Trial name
- NCT04734080
- Testing
- Dronabinol 5mg Cap
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
Blood Flow Restriction Training in Individuals Awaiting Total Knee Replacement
The aim is to demonstrate that preoperative exercises (pre-habilitation) using blood-flow restriction training (BFRT) is safe, well tolerated, improves muscle function, decreases functional limitation, and increases physical…
- Trial name
- NCT06111690
- Testing
- Blood Flow Restriction Training (BFRT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio