Clinical trials: Replacement
Total Hip Replacement
Bone Fixation of Mpact Double Mobility Cup
This study aims to evaluate long term fixation of the Mpact Double Mobility cup trough IMAGIKA technology.
- Trial name
- NCT02850575
- Testing
- Mpact Double Mobility cup
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Medacta International SA
Arthroplasty, Replacement, Shoulder, Glenoid Cavity
Long Term Follow-up After Primary or Revision Shoulder Arthroplasty With a Patient- Specific Glenius Implant
This post-market follow-up study investigates improvement in clinical and radiological outcome after reversed total shoulder arthroplasty with the patient-specific Glenius Glenoid Reconstruction system
- Conditions
- Arthroplasty, Replacement, Shoulder, Glenoid Cavity, Osteoarthritis of the Shoulder
- Trial name
- NCT03806881
- Testing
- reversed glenoid prothesis
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 24 people
- Sponsor
- Materialise
Rehabilitation, Telerehabilitation
Does Rehabilitation After Total Hip Or Knee Arthroplasty Work (DRAW2)
Overall frame: The overall or "parent" DRAW-project is a large-scale project run in Denmark that aims to provide substantial level 1A evidence-data related to the question: Does rehabilitation after total hip and knee…
- Conditions
- Rehabilitation, Telerehabilitation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- DRAW2 (NCT04960241)
- Testing
- Homebased telerehabilitation, Homebased rehabilitation, No physical rehabilitation
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Troels Mark Christensen
Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD)
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating…
- Conditions
- Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- TAVR-CT (NCT07107568)
- Testing
- Standard Invasive Coronary Angiography, PCD-CT-Guided Diagnostic Strategy
- Where
- 2 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Acute Kidney Failure Stage 3, Continuous Renal Replacement Therapy (CRRT)
Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW).
- Trial name
- PROTEIN-CRRT (NCT07596043)
- Testing
- High protein group, Standard protein group
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Chulalongkorn University
Arthroplasty, Replacement, Hip
Multimodal Analgesic Regimen for Total Hip Arthroplasty: An Initiative to Minimize Postoperative Opioid Use
This study examines whether patients undergoing total hip replacement surgery can manage their pain effectively while using fewer opioid pain medications. Participants will be randomly assigned to one of two groups.
- Trial name
- NCT07672808
- Testing
- Standard Multimodal Analgesic Regimen with Opioid Prescription, Opioid-Reduced Multimodal Analgesic Regimen with Printed Prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT)
Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT
Prismocitrate 18 is a continuous renal replacement therapy (CRRT) solution to be used as a renal replacement solution and as an anticoagulant to prevent blood clotting in the extracorporeal circuit.
- Conditions
- Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury (AKI)
- Trial name
- NCT05399537
- Testing
- Prismocitrate 18, PrisMax System Version 3.x with calcium line accessory
- Where
- 14 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vantive Health LLC
AKI - Acute Kidney Injury, Fluid Balance
Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy
The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury…
- Conditions
- AKI - Acute Kidney Injury, Fluid Balance, Acute Circulatory Failure, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- mVExUS-CRRT (NCT07346118)
- Testing
- mVExUS-guided fluid management
- Where
- 2 sites in Thailand
- Volunteers
- 126 people
- Sponsor
- Chulalongkorn University
Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting
The Effect of White and Pink Noise in Patients Undergoing Total Hip and Knee Arthroplasty
This study aims to investigate the effects of preoperative white noise and pink noise interventions on sleep quality, anxiety, postoperative pain, nausea, and physiological parameters in patients undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting, Anxiety, Postoperative Pain After Arthroscopic Knee Surgery
- Trial name
- NCT07858058
- Testing
- White Noise Intervention, Pink Noise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people
- Sponsor
- Ataturk University
Knee Replacement, Total
Implementation of a Pain Management Protocol for Total Knee Arthroplasty
Study question: Is there an ideal combination of intraoperative long acting analgesics (periarticular infiltration (PI), femoral nerve block (FB) and intrathecal opioids (IO)) to optimize post-operative functional recovery…
- Trial name
- NCT02474654
- Testing
- Bupivicaine, Fentanyl, Epimorphine
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Health Sciences North Research Institute
Aortic Valve Replacement
INSPIRIS China PMCF Study
The objective of this post-market trial is to evaluate long term safety and performance of the Edwards Lifesciences INSPIRIS RESILIA aortic valve in Chinese patients in a real-world clinical setting.
- Trial name
- INSPIRIS China (NCT05404880)
- Testing
- EDWARDS INSPIRIS RESILIA Aortic Valve
- Where
- 12 sites in China
- Volunteers
- 255 people
- Sponsor
- Edwards Lifesciences
Ethics, Cardiac Rehabilitation
The Role of 4 Different Consent Approaches on a Pilot Study to Increase Cardiac Rehabilitation Attendance
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend.
- Conditions
- Ethics, Cardiac Rehabilitation, Coronary Heart Disease (CHD), Heart Failure
- Trial name
- MOST-CR (NCT07123480)
- Testing
- Usual Care Group, More Support and Tools
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Baystate Medical Center
TKA, THA
Binaural Beats for Postoperative Pain and Anxiety Reduction
To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee…
- Conditions
- TKA, THA, Anxiety, Binaural Beats
- Trial name
- NCT07437469
- Testing
- Binaural Beats Audio Intervention, Music of Choice
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Pain Management, Arthroplasty Total Hip Replacement
QLESP Block Versus PENG+LFCN Block for Total Hip Arthroplasty
Total hip arthroplasty (THA) is a common surgery to replace damaged hip joints, but many patients experience significant pain after surgery, which can delay recovery and increase the need for strong pain medications (opioids).
- Trial name
- QLESP (NCT07771829)
- Testing
- QLESP Block, PENG+LFCN Block, ropivacaine
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Huazhong University of Science and Technology
Arthroplasty, Replacement
INHANCE Stemless Reverse Shoulder IDE
2:1 Randomized, Controlled, Multi-Center, Prospective, Pre-Market Study of the INHANCE Stemless Reverse Cementless Total Shoulder.
- Conditions
- Arthroplasty, Replacement, Shoulder
- Trial name
- NCT06323980
- Testing
- Reverse Total Shoulder
- Where
- 15 sites in United States
- Volunteers
- 168 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
Unicompartmental Versus Total Knee Replacement for Medial Compartment Knee Osteoarthritis
For patients with osteoarthritis affecting only the inner part of the knee, surgeons can offer either a partial knee replacement, which resurfaces the worn compartment alone, or a total knee replacement.
- Conditions
- Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- FLEX-UNI (NCT04913987)
- Testing
- Persona Partial Knee (PPK), Triathlon cruciate-retaining total knee system.
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Golden Jubilee National Hospital
Renal Dialysis, Renal Replacement Therapy
Machine Learning and Artificial Intelligence Algorithms to Optimize the Performance and Delivery of Acute Dialysis
SMART DIALYSIS - Scaling Machine Learning and Artificial Intelligence AlgoRithms to OpTimize the Performance and Delivery of Acute DIALYSIS.
- Conditions
- Renal Dialysis, Renal Replacement Therapy, Renal Diseases, Quality Health Care
- Trial name
- SMART DIALYSIS (NCT07312929)
- Testing
- intermittent OR continuous renal replacement therapies
- Where
- 15 sites in Canada
- Volunteers
- 7,500 people
- Sponsor
- University of Alberta
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Total Knee Arthroplasty Recovery, Total Knee Replacement
Telerehabilitation Versus Clinic-Based Rehabilitation for Functional Recovery Following Primary Total Knee Arthroplasty
The goal of this clinical trial is to determine if rehabilitation delivered by telehealth works as well as rehabilitation delivered in person at a clinic, for people recovering from total knee replacement surgery.
- Conditions
- Total Knee Arthroplasty Recovery, Total Knee Replacement, Total Knee Arthroplasty\(TKA\), Knee Arthritis Osteoarthritis
- Trial name
- NCT07834229
- Testing
- Rehabilitation treatment sessions focussing on education and exercise prescription.
- Where
- Australia
- Volunteers
- 108 people
- Sponsor
- The University of Western Australia