Clinical trials: Replacement
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Impact of Integrated Care Pathways for Prevention of Post-operative Urinary Retention (POUR)
A prospective randomized control trial will be conducted at Good Samaritan Hospital and TriHealth Evendale Hospital. Subjects will receive total hip or knee surgery and follow-up via standard care at the discretion of the…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Urinary Retention
- Trial name
- POUR (NCT03863743)
- Testing
- integrated care pathway, physician's standard of care
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- TriHealth Inc.
Gaucher Disease, Type 3
An Efficacy and Safety Study of AVR-RD-02 Compared to Enzyme Replacement Therapy for Treatment of Gaucher Disease Type 3
The purpose of this study is to evaluate the efficacy and safety of autologous hemotopoietic stem cell (HSC) gene therapy, AVR-RD-02, compared to enzyme replacement therapy, for the treatment of Gaucher disease Type 3 in male and…
- Trial name
- NCT05815004
- Testing
- Gene therapy, Enzyme Replacement Agent
- Sponsor
- AVROBIO
Manipulation Under Anesthesia
Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement
The specific aim of this study is to evaluate the effect of oral colchicine in primary TKA patients at 3 months following a manipulation under anesthesia.
- Trial name
- Colchine MUA (NCT02926248)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman
Knee Osteoarthritis
Survivorship of the Press Fit Condylar (P.F.C.) Sigma Fixed Bearing Knee With a Cobalt Chrome Tibial Tray
The study will determine the survivorship of the fixed bearing P.F.C. Sigma knee with a cobalt chrome tibial tray at 5 years.
- Trial name
- NCT00734019
- Testing
- P.F.C. Sigma Knee
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 650 people
- Sponsor
- DePuy International
Smokers
Cognitive Behaviour Therapy and Nicotine Replacement to Increase Tobacco Cessation
Background: Pharmacological strategies to improve smoking cessation have been largely studied. The efficacy of cognitive behavior therapy associated to nicotine replacement in tobacco cessation has not yet been demonstrated.
- Trial name
- NCT01734330
- Testing
- Cognitive behavioral therapy in group, Nicotine replacement
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital do Coracao
HIV Infections
Use of a Test That Evaluates How the Body Handles Insulin and Glucose
The purpose of this study is to find out if testosterone gel affects how the body handles insulin and glucose. Specific anti-HIV treatments may increase a patient's risk of certain diseases by causing metabolic problems such as…
- Trial name
- NCT00027092
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Arthropathy of Knee Joint
The Utilization of Nintendo Wii™ in Outpatient Rehabilitation Following Total Knee Replacement
The purpose of this study is to identify whether the utilization of the Nintendo Wii™ gaming system, as an adjunct to conventional outpatient rehabilitation therapy, influence outcomes of patients following total knee replacement…
- Trial name
- NCT01548664
- Testing
- Wii Fit, Lower Extremity Exercise
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Manuel Gomez, MD, MSc.
Pain, Chronic, Knee Pain Chronic
Pain Reprocessing Therapy in Post-Operative Knee Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery.
- Trial name
- REJOICE (NCT06800209)
- Testing
- Pain reprocessing therapy (PRT), Usual care
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Weill Medical College of Cornell University
Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis, Heye´s Syndrome
Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery
Acquired Von Willebrand disease (type 2A) has been described in patients with severe aortic stenosis, the association of aortic stenosis and Digestive bleeding due to this phenomena has received the name of Heye´s syndrome.
- Conditions
- Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis, Heye´s Syndrome, Severe Aortic Stenosis
- Trial name
- NCT01994330
- Testing
- desmopressin
- Where
- Chile
- Volunteers
- 13 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Knee Osteoarthritis
Navigation System for in Vivo Measurement of the Kinematics of the Knee
The knee prosthesis is a validated treatment for end-stage osteoarthritis, and this intervention usually provides a significant improvement in the quality of life of patients.
- Trial name
- NCT02467699
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Rehabilitation；Arthroplasty, Replacement, Knee
The Hierarchical Rehabilitation After Total Knee Arthroplasty
Knee osteoarthritis (KOA) is one of the diseases that seriously affect the quality of human life, resulting in a significant disease burden. Total knee arthroplasty (TKA) is one of the ultimate treatments for knee osteoarthritis.
- Trial name
- NCT05404568
- Testing
- Total knee arthroplasty
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Mitral Regurgitation
Sutra Hemi-valve First-in-Human Study
Study to evaluate the feasibility, safety and performance of the Sutra Hemi-valve Transcatheter Mitral Valve Replacement System in patients with moderate-severe and severe symptomatic mitral regurgitation who are at high risk for…
- Trial name
- NCT06552689
- Testing
- Sutra Hemi-valve Transcatheter Mitral Valve Replacement (TMVR) System
- Where
- New Zealand
- Volunteers
- 15 people
- Sponsor
- Sutra Medical, Inc.
Arthroplasty, Replacement, Knee, Analgesia
Analgesic Effect of Peripheral Cutaneous Nerve Block of Knee Joint After Total Knee Arthroplasty
Local anesthesia was performed on patients with total knee arthroplasty (TKA) through two different injection sites of local anesthetics and two local anesthetic drug .
- Trial name
- NCT05202730
- Testing
- New local anesthesia injection site and new local anesthetic drug formulation.
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Diwuweilong
Transcatheter Aortic Valve Replacement, Closure Technique
This Study Will Evaluate the Safety and Potential Complications of Dual ProGlide vs Single ProGlide and Angioseal for Common Femoral Arteriotomy Closure Following Transcatheter Aortic Valve Replacement
This prospective, randomized, parallel, single-center, open-label, non-inferiority study will evaluate the safety and potential complications of dual ProGlide vs single ProGlide and Angioseal for common femoral arteriotomy…
- Trial name
- TAVI-CLOSE (NCT06983938)
- Testing
- Double Perclose Proglide, Single Perclose Proglide plus Angioseal
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Baylor Research Institute
Total Knee Replacement, Quality of Life
Effect Of Counselıng
This study aims to determine the effect of counseling on quality of life and self-care agency for patients who are scheduled for TKR.
- Conditions
- Total Knee Replacement, Quality of Life, Nursing Caries
- Trial name
- NCT04916717
- Testing
- Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Uşak University
Osteoarthritis of the Knee
A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System
This study is designed to observe the long term clinical outcomes of patient-specific knee arthroplasty in patients with osteoarthritis.
- Trial name
- NCT01820650
- Testing
- iTotal G2 CR Knee Replacement System
- Where
- 9 sites in United States
- Volunteers
- 359 people
- Sponsor
- Restor3D
Arthroplasty
Continuous Adductor Canal Block (CACB) vs. Combined Spinal Epidural (CSE) in Total Knee Arthroplasty
Purpose: Compare continuous adductor canal block (CACB) to Combined Spinal Epidural (CSE) for total knee arthroplasty in terms of mobility, post-operative pain, and analgesic use.
- Trial name
- NCT02415465
- Testing
- Continuous Adductor Canal Block, General, Epidural
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Rush University Medical Center
Pain After Total Knee Arthroplasty, Pain, Postoperative
Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
This prospective observational study will compare the postoperative analgesic efficacy of two multimodal regional anesthesia combinations routinely used after total knee arthroplasty (TKA) performed under spinal anesthesia.
- Conditions
- Pain After Total Knee Arthroplasty, Pain, Postoperative, Arthroplasty, Replacement, Knee
- Trial name
- NCT07231692
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Pulmonary Regurgitation, Pulmonary Insufficiency
Pulmonic Valve REplacement Multi-discIpline EMEA Registry
The purpose of this registry is to retrospectively and prospectively obtain clinical data in consecutively treated patients, in order to demonstrate that the commercially available Edwards SAPIEN Valve with the RF3 delivery…
- Conditions
- Pulmonary Regurgitation, Pulmonary Insufficiency, Pulmonary Stenosis
- Trial name
- PREMIER (NCT01356108)
- Testing
- Transcatheter Pulmonic Valve Replacement (TPVR) (Edwards SAPIEN™ THV)
- Where
- 16 sites in Belgium, Germany and 7 more
- Volunteers
- 127 people
- Sponsor
- Edwards Lifesciences